In Vivo Irradiation Effects on Macromolecules
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Questions and Answers

What is the primary target of radiation in the biological system?

  • Cell membrane
  • Ribosomes
  • DNA molecule (correct)
  • Mitochondria

What is the primary mechanism by which radiation causes biological effects?

  • Both direct and indirect effects (correct)
  • Neither direct nor indirect effects
  • Direct effect
  • Indirect effect

What is the role of free radicals in the biological effects of radiation?

  • Free radicals have no effect on biological systems
  • Free radicals are energetic molecules that can transfer their excess energy to DNA, causing bond breaks (correct)
  • Free radicals are stable molecules that do not interact with DNA
  • Free radicals act as antioxidants to protect against radiation damage

How is hydrogen peroxide formed during the radiolysis of water?

<p>Hydrogen peroxide is formed by the interaction of two hydroxyl radicals (D)</p> Signup and view all the answers

What is the role of hydroperoxyl radicals in the radiolysis of water?

<p>Hydroperoxyl radicals are formed by the interaction of hydrogen radicals with oxygen (B)</p> Signup and view all the answers

Which of the following is a biologic factor that affects radiosensitivity?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following statements is correct about the effect of radiation on chromosomes?

<p>Radiation-induced chromosome aberrations follow a non-threshold dose-response relationship. (A)</p> Signup and view all the answers

What are isochromatids in the context of radiation-induced chromosome aberrations?

<p>A type of chromosome aberration where a chromosome has extra material. (A)</p> Signup and view all the answers

Which of the following statements is correct about the effect of radiation on DNA?

<p>Radiation can interact with DNA through direct and indirect effects. (A)</p> Signup and view all the answers

What does a 'single-hit' refer to in the context of radiation-induced chromosome aberrations?

<p>A chromosome that has been hit by a single radiation particle. (C)</p> Signup and view all the answers

Which of the following statements is incorrect about the effect of radiation on skin cells?

<p>The dose-response relationship for radiation-induced skin damage is linear and non-threshold. (A)</p> Signup and view all the answers

Which of the following cells are described as the most radiosensitive in the body?

<p>Lymphocytes and spermatogonia (B)</p> Signup and view all the answers

What is the primary target of radiation in a cell?

<p>DNA (B)</p> Signup and view all the answers

Which type of DNA damage is considered lethal for a cell?

<p>Double-strand breaks (B)</p> Signup and view all the answers

What is the primary mechanism by which cells die after irradiation?

<p>Mitotic death (D)</p> Signup and view all the answers

What is the consequence of a base damage in DNA?

<p>It alters the base sequence, potentially causing a mutation (C)</p> Signup and view all the answers

Which of the following is a direct effect of radiation on water molecules?

<p>All of the above (D)</p> Signup and view all the answers

What is the primary mechanism by which radiation causes damage to DNA?

<p>Both direct ionization and indirect damage through free radicals (A)</p> Signup and view all the answers

What is the primary consequence of a double-strand break in DNA?

<p>It may lead to cell death (A)</p> Signup and view all the answers

Which of the following is NOT a type of radiation damage described in the text?

<p>Irreversible damage (D)</p> Signup and view all the answers

What is the primary function of DNA in a cell?

<p>Storing genetic information (D)</p> Signup and view all the answers

Which of the following statements about single-strand breaks in DNA is correct?

<p>They are relatively inconsequential and can be efficiently repaired (D)</p> Signup and view all the answers

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