In-Vitro Dissolution Studies

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Questions and Answers

Biopharmaceutics lab 4 In vitro dissolution study of oral tablet Drug ______

dissolution

The ______ test: is an in-vitro test for measuring the time required for a given percentage of the drug substance in a tablet to go into solution under a specified set of conditions.

dissolution

When drug is slightly soluble the rate limiting factor for absorption is ______

dissolution

The dissolution test is an important quality control procedure used to: confirm batch-to-batch ______.

<p>reproducibility</p> Signup and view all the answers

A number of formulation and manufacturing factors can affect the disintegration and ______ of a tablet , including Particle size of drug substance.

<p>dissolution</p> Signup and view all the answers

What is the purpose of the dissolution test?

<p>The purpose of the dissolution test is to measure the time required for a given percentage of the drug substance in a tablet to go into solution under specific conditions.</p> Signup and view all the answers

What is the rate limiting factor for absorption when the drug is slightly soluble?

<p>When the drug is slightly soluble, the rate limiting factor for absorption is dissolution.</p> Signup and view all the answers

How are dissolution and drug release tests used as a measure of drug product performance?

<p>Dissolution and drug release tests are used as a measure of drug product performance in vitro when linked to product performance in vivo.</p> Signup and view all the answers

What are some factors that can affect the disintegration and dissolution of a tablet?

<p>Some factors that can affect the disintegration and dissolution of a tablet include the particle size of the drug substance and formulation and manufacturing factors.</p> Signup and view all the answers

What are the two rate limiting factors for absorption?

<p>The rate limiting factors for absorption are dissolution for slightly soluble drugs, and permeability for highly soluble drugs.</p> Signup and view all the answers

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