10 Questions
Biopharmaceutics lab 4 In vitro dissolution study of oral tablet Drug ______
dissolution
The ______ test: is an in-vitro test for measuring the time required for a given percentage of the drug substance in a tablet to go into solution under a specified set of conditions.
dissolution
When drug is slightly soluble the rate limiting factor for absorption is ______
dissolution
The dissolution test is an important quality control procedure used to: confirm batch-to-batch ______.
reproducibility
A number of formulation and manufacturing factors can affect the disintegration and ______ of a tablet , including Particle size of drug substance.
dissolution
What is the purpose of the dissolution test?
The purpose of the dissolution test is to measure the time required for a given percentage of the drug substance in a tablet to go into solution under specific conditions.
What is the rate limiting factor for absorption when the drug is slightly soluble?
When the drug is slightly soluble, the rate limiting factor for absorption is dissolution.
How are dissolution and drug release tests used as a measure of drug product performance?
Dissolution and drug release tests are used as a measure of drug product performance in vitro when linked to product performance in vivo.
What are some factors that can affect the disintegration and dissolution of a tablet?
Some factors that can affect the disintegration and dissolution of a tablet include the particle size of the drug substance and formulation and manufacturing factors.
What are the two rate limiting factors for absorption?
The rate limiting factors for absorption are dissolution for slightly soluble drugs, and permeability for highly soluble drugs.
Test your knowledge on in-vitro dissolution studies of oral tablets in this quiz. Learn about the process of drug dissolution and absorption in solid dosage forms. Explore the factors that affect drug solubility and the importance of dissolution testing in drug development.
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