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Questions and Answers
Explain the importance of elastic fibres in the wall of the aorta
Explain the importance of elastic fibres in the wall of the aorta
It stretches/expands under high pressure (when ventricle contracts). It recoils back under low pressure (when ventricle relaxes). This smooths blood flow and helps maintain blood pressure
Explain the importance of muscle fibres in the wall of an arteriole
Explain the importance of muscle fibres in the wall of an arteriole
The muscle contracts to constrict the arteriole, helping to regulating blood flow to the capillaries
Explain why a type O blood can only receive blood from O-type donor
Explain why a type O blood can only receive blood from O-type donor
erythrocytes of O-type do not have antigens present on cell. Plasma of O-type has antibodies for both A and B antigens. If blood with A and/or B antigens is present, O-type plasma antibodies will destroy the donated blood. This results in agglutination.
What are the four blood groups and how are they determined?
What are the four blood groups and how are they determined?
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Explain the antigen-antibody relationship in blood group A.
Explain the antigen-antibody relationship in blood group A.
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Describe the characteristics of blood group B.
Describe the characteristics of blood group B.
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What is unique about blood group AB in terms of antigens and antibodies?
What is unique about blood group AB in terms of antigens and antibodies?
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Explain the antigen-antibody composition of blood group O.
Explain the antigen-antibody composition of blood group O.
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What can happen when Rh-negative blood is transfused into an Rh-positive individual?
What can happen when Rh-negative blood is transfused into an Rh-positive individual?
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What is the role of platelets in blood clotting?
What is the role of platelets in blood clotting?
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Describe the function of T lymphocytes in the immune system.
Describe the function of T lymphocytes in the immune system.
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What is the significance of red blood cell transfusions in cases of severe blood loss?
What is the significance of red blood cell transfusions in cases of severe blood loss?
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Explain the role of neutrophils in the immune system.
Explain the role of neutrophils in the immune system.
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How do memory T cells contribute to long-term immunity?
How do memory T cells contribute to long-term immunity?
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Describe the structure of the mammalian heart and its function.
Describe the structure of the mammalian heart and its function.
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Explain the role of capillaries in fluid exchange in the body.
Explain the role of capillaries in fluid exchange in the body.
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How do metabolic wastes and lactic acid act as vasodilators in the body?
How do metabolic wastes and lactic acid act as vasodilators in the body?
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Describe the structure and function of erythrocytes (red blood cells) in the body.
Describe the structure and function of erythrocytes (red blood cells) in the body.
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What is the primary function of platelets in the bloodstream?
What is the primary function of platelets in the bloodstream?
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Explain how leukocytes (white blood cells) contribute to the immune response.
Explain how leukocytes (white blood cells) contribute to the immune response.
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What substances are transported by plasma in the bloodstream?
What substances are transported by plasma in the bloodstream?
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What is the role of the septum in the heart?
What is the role of the septum in the heart?
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Explain the process of vasoconstriction in arteries.
Explain the process of vasoconstriction in arteries.
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Describe the difference between systole and diastole in the cardiac cycle.
Describe the difference between systole and diastole in the cardiac cycle.
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How does CPR (Cardiopulmonary Resuscitation) help maintain blood circulation?
How does CPR (Cardiopulmonary Resuscitation) help maintain blood circulation?
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What is the function of arterioles in the circulatory system?
What is the function of arterioles in the circulatory system?
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Explain the significance of the aorta in the circulatory system.
Explain the significance of the aorta in the circulatory system.
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Explain the challenges giraffes face in circulating blood effectively throughout their bodies.
Explain the challenges giraffes face in circulating blood effectively throughout their bodies.
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Describe the adaptations in the giraffe's circulatory system that help ensure oxygenated blood reaches all parts of its body.
Describe the adaptations in the giraffe's circulatory system that help ensure oxygenated blood reaches all parts of its body.
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Explain the cardiac cycle and define systole and diastole.
Explain the cardiac cycle and define systole and diastole.
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Discuss the roles of vasodilation and vasoconstriction in blood circulation.
Discuss the roles of vasodilation and vasoconstriction in blood circulation.
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What is the importance of papillary muscles in the heart?
What is the importance of papillary muscles in the heart?
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Explain the function of the pulmonary artery compared to other arteries in the body.
Explain the function of the pulmonary artery compared to other arteries in the body.
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Explain the role of vasodilators in regulating blood flow through capillaries during exercise.
Explain the role of vasodilators in regulating blood flow through capillaries during exercise.
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How do semilunar valves contribute to maintaining blood flow in the heart?
How do semilunar valves contribute to maintaining blood flow in the heart?
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What is the significance of the 'lub dub' sound in heartbeats?
What is the significance of the 'lub dub' sound in heartbeats?
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Explain why the left ventricle wall is thicker compared to the right ventricle.
Explain why the left ventricle wall is thicker compared to the right ventricle.
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Describe the process of blood clot formation and its significance.
Describe the process of blood clot formation and its significance.
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What is the function of platelets in the process of blood clotting?
What is the function of platelets in the process of blood clotting?
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Explain how a thrombus can lead to a serious medical condition like a stroke.
Explain how a thrombus can lead to a serious medical condition like a stroke.
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What is the role of fibrin in the process of blood clotting?
What is the role of fibrin in the process of blood clotting?
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Explain the importance of chordae tendineae in the functioning of the heart valves.
Explain the importance of chordae tendineae in the functioning of the heart valves.
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How do arterioles help regulate blood flow in muscle tissues during exercise?
How do arterioles help regulate blood flow in muscle tissues during exercise?
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The aorta has many elastic fibres in its wall. An arteriole has many muscle fibres in its wall. Explain the importance of elastic fibres in the wall of the aorta.
The aorta has many elastic fibres in its wall. An arteriole has many muscle fibres in its wall. Explain the importance of elastic fibres in the wall of the aorta.
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Explain the importance of muscle fibres in the wall of an arteriole
Explain the importance of muscle fibres in the wall of an arteriole
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Describe the structure of the mammalian heart (6 marks)
Describe the structure of the mammalian heart (6 marks)
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Why can an O type blood person only receive blood from an O-type donor
Why can an O type blood person only receive blood from an O-type donor
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For theres blood groups: A, B, AB, O, Rh+ and Rh-, list the antigens present on erythrocyte and antibodies present in plasma
For theres blood groups: A, B, AB, O, Rh+ and Rh-, list the antigens present on erythrocyte and antibodies present in plasma
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Define agglutination
Define agglutination
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State what is meant by blood group
State what is meant by blood group
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Describe what a blood transfusion is and reasons why someone may require one
Describe what a blood transfusion is and reasons why someone may require one
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Explain the importance of matching blood groups with blood donors and blood recipients
Explain the importance of matching blood groups with blood donors and blood recipients
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Compare and contrast the ABO blood groups and Rh blood groups
Compare and contrast the ABO blood groups and Rh blood groups
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1 Describe the appearance of a red blood cell. What does the appearance tell you about the structure of the cell?
1 Describe the appearance of a red blood cell. What does the appearance tell you about the structure of the cell?
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3 What is the approximate difference in size between red blood cells and white blood cells?
3 What is the approximate difference in size between red blood cells and white blood cells?
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4 What is the approximate ratio of numbers of red blood cells to white cells?
4 What is the approximate ratio of numbers of red blood cells to white cells?
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5 Were you able to see any platelets? Suggest why platelets are difficult to see with a school microscope.
5 Were you able to see any platelets? Suggest why platelets are difficult to see with a school microscope.
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Study Notes
Blood Groups
- Blood groups are determined by antigens on the surface of red blood cells (RBCs)
- There are four main blood groups: A, B, AB, and O
- Each blood group has specific antigens and antibodies:
- Group A: A antigens and anti-B antibodies
- Group B: B antigens and anti-A antibodies
- Group AB: A and B antigens and no antibodies
- Group O: no antigens and anti-A and anti-B antibodies
Rh Factor
- Rh factor is a protein found on the surface of RBCs
- Individuals with Rh factor are considered Rh-positive, while those without it are Rh-negative
- When Rh-negative blood is transfused into an Rh-positive individual, the recipient's immune system may react to the Rh antigen, leading to an immune response
Capillaries
- Capillaries are crucial for the exchange of gases, nutrients, and waste products between the blood and tissues
- Functions of capillaries:
- Gas exchange: oxygen and carbon dioxide exchange between the blood and tissues
- Nutrient delivery: essential nutrients such as glucose, amino acids, and fatty acids are delivered to the tissues
- Waste removal: metabolic waste products such as carbon dioxide and urea are removed from the tissues
- Fluid exchange: fluid exchange between the blood and the interstitial fluid surrounding the cells
Heart and Circulation
- The heart is a muscular organ that pumps blood throughout the body
- Structure of the heart:
- Four chambers: two atria (upper) and two ventricles (lower)
- Right side of the heart: receives deoxygenated blood from the body and pumps it to the lungs for oxygenation
- Left side of the heart: receives oxygenated blood from the lungs and pumps it to the rest of the body
- Importance of the heart and circulation:
- Delivers oxygen and nutrients to the tissues
- Removes waste products from the tissues
- Maintains fluid balance and regulates blood pressure
Blood Components
- Plasma: the liquid component of blood, making up about 55% of total blood volume
- Contains water, proteins, electrolytes, hormones, gases, and waste products
- Erythrocytes (Red Blood Cells):
- Disc-shaped cells that lack a nucleus and most organelles
- Primary function: transport oxygen from the lungs to the tissues and carry carbon dioxide from the tissues back to the lungs
- Platelets: small, irregularly shaped cell fragments derived from megakaryocytes
- Crucial for blood clotting (hemostasis)
- Leukocytes (White Blood Cells): nucleated cells involved in the immune response
- Classified into several types, including neutrophils, lymphocytes, monocytes, eosinophils, and basophils
Blood Pressure and Blood Flow
- Blood pressure: the pressure of blood against the walls of the arteries
- Blood pressure reading: "120/80" refers to systolic pressure (120) and diastolic pressure (80)
- Vasodilation and vasoconstriction:
- Vasodilation: increased blood flow to the tissues, allowing for increased oxygen delivery and removal of waste products
- Vasoconstriction: decreased blood flow to the tissues, reducing blood pressure and cardiac output
Cardiac Cycle and Heart Rate
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Cardiac cycle: the sequence of events that occurs in the heart from one heartbeat to the next
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Heart rate: the number of heartbeats per minute
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Cardiac output: the volume of blood pumped by the heart per minute
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Calculation of cardiac output: CO = HR × SV### Giraffe's Circulatory System
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Giraffes' unique challenge: circulating blood effectively due to tall stature
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Large, powerful, and muscular heart to pump blood against gravity
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Thick-walled blood vessels to maintain blood pressure and prevent collapse
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Specialized adaptations: high arterial blood pressure and one-way valves in neck arteries to prevent backflow when lowering head to drink
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Oxygenated blood reaches all parts of body, including brain, even when standing upright
Cardiac Cycle
- Sequence of events in one complete heart beat: cardiac cycle
- Pumping phase: systole (heart muscle contracts)
- Filling phase: diastole (heart muscle relaxes)
- Atrial systole: contraction of atria, forcing blood into ventricles
- Ventricular systole: ventricles contract, forcing blood into arteries
Blood Flow Regulation
- Blood flow to and from cells changes in response to cellular activity
- Two ways to change blood flow: heart output and blood vessel diameter
- Vasodilation: widening of blood vessels, increasing blood flow and decreasing blood pressure
- Vasoconstriction: narrowing of blood vessels, decreasing blood flow and increasing blood pressure
Importance of Papillary Muscles
- Located in ventricles, connected to atrioventricular valves via chordae tendineae
- Prevent inversion or prolapse of valves during ventricular contraction
- Contract just before ventricles contract, tensioning chordae tendineae and preventing valve backflow
Pulmonary Artery
- Carries deoxygenated blood from right ventricle to lungs for oxygenation
- Right side of heart receives deoxygenated blood from body and pumps to lungs for oxygenation
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