Immunology Quiz: Immune System Functions
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Questions and Answers

What is one function of activated complement proteins?

  • They increase blood pressure.
  • They form holes in bacterial membranes causing lysis. (correct)
  • They decrease inflammation.
  • They produce antibodies.
  • Histamine reduces vascular permeability and smooth muscle contraction in the lungs.

    False (B)

    Name two strategies used by the innate immune system to respond to infection.

    Inflammation and fever.

    Lysozymes, found in tears and saliva, are known to __________ cells.

    <p>lyse</p> Signup and view all the answers

    Match the following surface chemicals with their functions:

    <p>Lysozymes = Lyses cells Sebum = Prevents microbial growth Hydrochloric acid = Kills microorganisms Mucus = Traps microorganisms</p> Signup and view all the answers

    What is the primary effect of paracetamol on fever?

    <p>Decreases production of PGE2 (A)</p> Signup and view all the answers

    Fever can help leucocytes function better.

    <p>True (A)</p> Signup and view all the answers

    What type of proteins are involved in the complement system?

    <p>Complement proteins</p> Signup and view all the answers

    Natural killer cells identify self-cells that lack _____ to target infected or cancerous cells.

    <p>MHC-1</p> Signup and view all the answers

    Match the following components with their roles or characteristics:

    <p>Macrophages = Eliminate entire cells by phagocytosis Natural killer cells = Induce apoptosis in target cells PAMPs = Pathogen associated molecular markers Compliment = Circulates in inactive form in the blood</p> Signup and view all the answers

    Which of the following cells are considered part of the non-specific immune response?

    <p>Macrophages (C)</p> Signup and view all the answers

    Complement proteins are functional and active as soon as they are in circulation.

    <p>False (B)</p> Signup and view all the answers

    What triggers phagocytosis in phagocytes?

    <p>Binding of PRRs to PAMPs</p> Signup and view all the answers

    Which of the following best describes kinins?

    <p>They cause vasodilation and attract neutrophils. (A)</p> Signup and view all the answers

    Interferon is produced primarily by neutrophils to enhance virus production.

    <p>False (B)</p> Signup and view all the answers

    What type of immune response is primarily mediated by T lymphocytes?

    <p>Cell-mediated response</p> Signup and view all the answers

    Pyrogens are chemicals released by ______ that stimulate fever production.

    <p>neutrophils and monocytes</p> Signup and view all the answers

    Match the following components of the immune system with their primary functions:

    <p>Kinins = Cause vasodilation and attract neutrophils Interferon = Interferes with virus infection Complement = Promotes phagocytosis and attracts immune cells Prostaglandins = Stimulates pain receptors and causes smooth muscle relaxation</p> Signup and view all the answers

    Which statement about humoral and cell-mediated responses is true?

    <p>Humoral response is mediated by B lymphocytes. (C)</p> Signup and view all the answers

    The acquired immune response is generalized and acts quickly.

    <p>False (B)</p> Signup and view all the answers

    In which part of the body do T lymphocytes mature?

    <p>Thymus</p> Signup and view all the answers

    What is one function of the skin in the immune system?

    <p>To secrete fatty acids that inhibit bacterial growth (B)</p> Signup and view all the answers

    The acquired immune system is present from birth and is fast-acting.

    <p>False (B)</p> Signup and view all the answers

    What are the four cardinal signs of inflammation?

    <p>Heat, redness, swelling, pain</p> Signup and view all the answers

    The body's temperature is regulated by the ______, which resets the set point during fever.

    <p>hypothalamus</p> Signup and view all the answers

    Match the following components with their roles in the immune system:

    <p>Histamine = Initiates inflammatory response Interferon = Inhibits viral replication Complement = Enhances immune response Prostaglandins = Mediates fever response</p> Signup and view all the answers

    What is one of the roles of natural killer cells in the innate immune response?

    <p>Destroying infected cells (C)</p> Signup and view all the answers

    What type of medication is often required to prevent organ rejection?

    <p>Immunosuppressive medication</p> Signup and view all the answers

    Fever is caused by the release of leukotrienes.

    <p>False (B)</p> Signup and view all the answers

    Flashcards

    What is the immune system?

    The immune system is a complex network of cells, tissues, and organs that work together to protect the body from harmful substances, such as bacteria, viruses, fungi, and parasites.

    What is the innate immune system?

    The innate immune system is the body's first line of defense against infection. It is non-specific, meaning it attacks any foreign substance that enters the body. This system is present from birth.

    What is the acquired or adaptive immune system?

    The acquired or adaptive immune system is the body's second line of defense. It is specific, meaning it targets specific pathogens that have already entered the body. This system learns and remembers pathogens, so it can respond more effectively next time.

    What is inflammation?

    Inflammation is the body's natural response to injury or infection. It brings immune cells to the site of injury or infection to fight off invaders and begin the healing process. The four cardinal signs of inflammation are redness, swelling, heat, and pain.

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    What is fever?

    Fever is a temporary increase in body temperature that is caused by pyrogens. Pyrogens are substances that trigger the release of prostaglandins, which reset the body's set temperature.

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    What is phagocytosis?

    Phagocytosis is the process by which certain cells in the immune system, called phagocytes, engulf and destroy pathogens. This is a key part of the innate immune response.

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    What are natural killer cells?

    Natural killer (NK) cells are a type of white blood cell that kill cells that are infected with viruses or have become cancerous. They are part of the innate immune system and are important for controlling viral infections and preventing the spread of cancer.

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    What is the complement system?

    The complement system is a collection of proteins that work together to destroy pathogens and help other immune cells. It is part of the innate immune system. The cascade of protein activation creates a chain reaction that ultimately damages the pathogen.

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    Complement Cascade

    A series of reactions where each component activates the next, leading to the formation of activated complement proteins.

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    Complement Lysis

    Activated complement proteins can puncture bacterial cell membranes, causing the bacteria to burst.

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    Complement and Phagocytosis

    Complement proteins attached to bacteria act as flags, signaling macrophages to engulf and destroy the bacteria.

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    Complement and Inflammation

    Complement proteins attract immune cells to infected areas, promoting inflammation.

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    Histamine

    A chemical released by mast cells, basophils and platelets, triggering vasodilation, increased vascular permeability, and other effects.

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    Phagocytosis

    A natural defense mechanism that involves cells like macrophages, neutrophils, and dendritic cells engulfing and destroying entire cells, such as bacteria or viruses. It's the first line of defense against pathogens.

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    PAMPs (Pathogen-Associated Molecular Patterns)

    Molecules found on pathogens that are recognized by pattern recognition receptors (PRRs) on immune cells, triggering phagocytosis.

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    PRRs (Pattern Recognition Receptors)

    Receptors on immune cells that recognize and bind to PAMPs, initiating phagocytosis and other immune responses.

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    MHC (Major Histocompatibility Complex)

    Antigen-presenting molecules found on cells that display fragments of pathogens or other antigens to other cells of the immune system, especially T cells.

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    Natural Killer Cells

    A type of lymphocyte that plays a critical role in innate immunity by targeting cells that lack MHC1 or are displaying PAMPs, potentially indicating infection or cancer.

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    Perforins

    Proteins released by natural killer cells that create pores in target cells, allowing granzymes to enter and induce apoptosis.

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    Granzymes

    Enzymes released by natural killer cells that enter target cells through perforin-induced channels and trigger programmed cell death (apoptosis).

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    Apoptosis

    Programmed cell death, where a cell self-destructs in a controlled manner, removing potentially dangerous or infected cells.

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    What are kinins?

    Polypeptides derived from plasma proteins that cause vasodilation, increase vascular permeability, stimulate pain receptors, and attract neutrophils.

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    What is interferon?

    A protein produced by most cells that interferes with viral production and infection.

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    What are prostaglandins?

    A group of lipids produced by mast cells that cause smooth muscle relaxation and vasodilation, increase vascular permeability, and stimulate pain receptors.

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    What are leukotrienes?

    A group of lipids, primarily produced by mast cells and basophils, that cause prolonged smooth muscle contraction (especially in the lung bronchioles), increase vascular permeability, and attract neutrophils and eosinophils.

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    What are pyrogens?

    Chemicals released by neutrophils, monocytes, and other cells that stimulate fever production.

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    What is the acquired (adaptive) immune response?

    A slow but very powerful immune response that is specific to the pathogen and has memory.

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    How is the acquired immune response organized?

    A complex immune response that includes a humoral response (mediated by B lymphocytes and antibodies) and a cell-mediated response (mediated by T lymphocytes).

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    Study Notes

    Immune System Overview

    • The immune system is a complex system that defends the body against infection and disease.
    • It consists of two main parts: innate immunity and adaptive immunity.

    Innate Immunity

    • Present from birth
    • Provides a rapid, non-specific response to pathogens.
    • Includes physical barriers (e.g., skin, mucous membranes) and chemical barriers (e.g., enzymes, acids).
    • Contains cellular components, such as phagocytes (macrophages, neutrophils), natural killer (NK) cells, and the complement system.
    • Trigger an inflammatory response to infection.
    • Cardinal signs of inflammation: heat, redness, swelling, and pain.
    • Chemicals like histamine, kinins, interferons, prostaglandins, leukotrienes, and pyrogens play a role in this system.
    • Fever is also an innate immune response to pathogens. It raises body temperature to make some pathogens less effective.

    Adaptive Immunity

    • Developed over time.
    • Specific response to particular pathogens.
    • Involves lymphocytes, recognizing antigens with a specific receptor.
    • Two types: humoral (antibody-mediated) and cell-mediated.
    • Humoral Immunity is mediated by B-lymphocytes producing antibodies that target pathogens.
    • Cell-mediated immunity is mediated by T-lymphocytes that attack infected cells directly, using cytotoxic cells..

    Function of Immunity

    • Protects the body.
    • Protects against microbes including bacteria, viruses, parasites, fungi and toxins
    • It is crucial for survival

    Autoimmune Diseases

    • Diseases where the immune system attacks the body's own tissues.
    • Examples: rheumatoid arthritis

    Organ Transplants

    • Risk of rejection due to the immune system recognizing the organ as foreign.
    • Immunosuppressive drugs needed.

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    Immune System Introduction PDF

    Description

    Test your knowledge on the functions of the immune system, including the roles of activated complement proteins and innate immune responses. This quiz covers key concepts such as phagocytosis, fever, and the characteristics of immune cells. Challenge your understanding of both specific and non-specific immune mechanisms.

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