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Questions and Answers
Which type of lymphocyte is involved in cell-mediated immunity?
Which type of lymphocyte is involved in cell-mediated immunity?
What is the primary function of secreted antibodies in humoral immunity?
What is the primary function of secreted antibodies in humoral immunity?
How does cell-mediated immunity eliminate reservoirs of infection?
How does cell-mediated immunity eliminate reservoirs of infection?
What characteristic of the immune system allows it to mount larger and more effective responses to repeated exposures to the same antigen?
What characteristic of the immune system allows it to mount larger and more effective responses to repeated exposures to the same antigen?
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Which property of the acquired immune response involves the ability to discriminate between self and non-self antigens?
Which property of the acquired immune response involves the ability to discriminate between self and non-self antigens?
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Which lymphocyte is specifically involved in the activation of macrophages to kill phagocytosed microbes?
Which lymphocyte is specifically involved in the activation of macrophages to kill phagocytosed microbes?
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In what form are antibodies found within the humoral immunity response?
In what form are antibodies found within the humoral immunity response?
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What characteristic allows the immune system to recognize billions of different antigens?
What characteristic allows the immune system to recognize billions of different antigens?
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Which type of immunity involves the use of secreted antibodies to block infections?
Which type of immunity involves the use of secreted antibodies to block infections?
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Which property of the acquired immune response involves the immune system being able to react against a variety of microbes while avoiding the host's own antigens?
Which property of the acquired immune response involves the immune system being able to react against a variety of microbes while avoiding the host's own antigens?
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Study Notes
Cell-Mediated Immunity
- T lymphocytes (T cells) play a critical role in cell-mediated immunity.
- It involves direct attack on infected or abnormal cells, primarily by cytotoxic T cells.
Humoral Immunity
- Secreted antibodies primarily function to neutralize pathogens and toxins.
- They can opsonize pathogens, marking them for destruction by other immune cells.
Elimination of Infection Reservoirs
- Cell-mediated immunity eliminates reservoirs of infection by activating T cells to destroy infected host cells.
- This response restricts the spread of pathogens within the host.
Immunological Memory
- The immune system's memory allows it to mount larger and more effective responses upon subsequent exposures to the same antigen.
- This is primarily facilitated by memory T and B cells.
Self vs. Non-Self Discrimination
- The property of distinguishing between self and non-self antigens is known as tolerance.
- This ensures that the immune system does not attack the body’s own tissues.
Activation of Macrophages
- CD4+ T cells, also known as helper T cells, are key in activating macrophages to enhance their ability to kill phagocytosed microbes.
- They secrete cytokines that boost the functionality of macrophages.
Antibody Form in Humoral Response
- Antibodies are typically found in a soluble form in bodily fluids, such as blood and lymphatic fluid.
- They are produced by B cells in response to specific antigens.
Recognition of Diverse Antigens
- The immune system can recognize billions of different antigens due to the diverse repertoire of B and T cell receptors generated through random genetic recombination.
- This diversity is essential for effective immune responses against various pathogens.
Antibody-Mediated Immunity
- Humoral immunity is characterized by the use of secreted antibodies to block infections by neutralizing pathogens or preventing their entry into host cells.
- It includes mechanisms like agglutination and activation of the complement system.
Reactivity Against Microbes
- The acquired immune response has the ability to react against a vast array of microbes while avoiding reaction to the host's own antigens, a property known as specificity.
- This balance is crucial for preventing autoimmune disorders.
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Description
Test your knowledge of the immune system, including cell-mediated and humoral immunity, and the characteristics of the acquired immune response.