Immunology MCQs

Immunology Multiple Choice Questions (MCQs)

• Primary Lymphoid Organs: The thymus is a primary lymphoid organ.

• Complement Pathway Activation: IgM is the antibody isotype most effective in activating the classical complement pathway.

• MHC Class I Function: MHC Class I molecules present intracellular antigens to CD8+ T cells.

• Affinity Maturation Location: Affinity maturation occurs in the germinal centers of lymph nodes.

• Antibody Production: Plasma cells are the primary producers of antibodies.

• Alternative Pathway Activation: C3 is the first complement protein activated in the alternative pathway.

• Membrane Attack Complex (MAC): The MAC creates pores in pathogen membranes.

• Macrophage Activation: IFN-γ is critical for activating macrophages in a TH1 response.

• Chronic Inflammation: Granuloma formation is a characteristic of chronic inflammation.

• Type I Hypersensitivity: IgE and mast cells are involved in Type I hypersensitivity.

• V(D)J Recombination: Recombinase (RAG1/2) is the enzyme responsible for V(D)J recombination in B and T cells.

• Secondary Lymphoid Organ: The spleen is a secondary lymphoid organ.

• Dendritic Cell Role: Dendritic cells present antigens to T cells.

• Classical Complement Pathway Regulation: C1 inhibitor (C1-INH) regulates the classical complement pathway.

• TH2 Cells: TH2 cells are involved in allergy and parasitic infections.

• CD8+ T Cell Recognition: CD8+ T cells recognize MHC Class I on target cells.

• Type III Hypersensitivity: Immune complexes mediate Type III hypersensitivity.

• Hygiene Hypothesis: Reduced pathogen exposure can lead to increased autoimmune and allergic diseases (according to the hygiene hypothesis).

• Alternative Pathway Stabilization: Properdin stabilizes C3b on pathogen surfaces in the alternative pathway.

• Histamine Production: Mast cells produce histamine during inflammation.

• T Regulatory (TREG) Cell Function: TREG cells suppress immune responses.

• Membrane Attack Complex Target: The MAC targets the lipid bilayers of pathogens.

• TH17 Cell Differentiation: IL-23 drives the differentiation of TH17 cells.

• Adaptive Immunity Feature: Immunological memory is a key feature of adaptive immunity.

• Antibody-Dependent Complement Pathway: The classical pathway requires antibodies to initiate.

• Acute Phase Proteins: Acute phase proteins enhance phagocytosis and inflammation.

• Acute Inflammation First Responder: Neutrophils are the first immune cells to arrive during acute inflammation.

• IL-2 Function: IL-2 promotes T cell proliferation.

• MHC Class II Antigen Processing: The endocytic pathway in MHC Class II antigen processing involves lysosomal degradation of extracellular antigens.

• Rheumatoid Arthritis Marker: Rheumatoid factor (RF) is a lab marker associated with rheumatoid arthritis.

Test your knowledge of immunology with these multiple choice questions covering key concepts such as lymphoid organs, antibody production, and hypersensitivity. Evaluate your understanding of the complement system, MHC function, and chronic inflammation.