Immunology: Major Histocompatibility Complex (MHC)
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Questions and Answers

Where are NK progenitors and immature cells found?

  • Thymus
  • Peripheral blood
  • Spleen
  • Bone marrow (correct)
  • What is the primary function of Natural Killer (NK) cells?

  • Produce cytokines
  • Produce antibodies
  • Regulate adaptive immunity
  • Kill tumor cells and virus-infected cells (correct)
  • What percentage of circulating lymphocytes do NK cells typically constitute?

  • 5–20% (correct)
  • 25–40%
  • 1–5%
  • 45–60%
  • Which molecule is produced by lymphocytes and plasma cells, and is known as antibody in its secreted form?

    <p>Immunoglobulin (Ig)</p> Signup and view all the answers

    What is the lifespan of most NK cells after viral exposure?

    <p>A few days to a few weeks</p> Signup and view all the answers

    Which cell surface markers are used to differentiate developmental stages of B precursor cells?

    <p>CD19 and/or CD20</p> Signup and view all the answers

    Which major gene loci are involved in Class II MHC molecules?

    <p>HLA-DP, HLA-DQ, HLA-DR</p> Signup and view all the answers

    Which type of T cells are MHC Class I molecules primarily presenting antigens to?

    <p>T cytotoxic cells (CD8+ T cells)</p> Signup and view all the answers

    What is the role of Natural Killer (NK) cells in innate immune responses?

    <p>Releasing cytokines to activate macrophages</p> Signup and view all the answers

    How do MHC Class II molecules present antigens to immune cells?

    <p>With peptides from intracellular pathogens to CD4+ T cells</p> Signup and view all the answers

    Which molecules do NK cells recognize on infected cells or stressed cells?

    <p>MHC Class I molecules</p> Signup and view all the answers

    Which type of T cell co-receptor is involved in binding with antigens/MHC during T cell activation?

    <p>CD4</p> Signup and view all the answers

    Which population of lymphoid cells were first identified as cytotoxic cells capable of killing tumor cells and virus-infected cells in the absence of immune sensitization?

    <p>NK cells</p> Signup and view all the answers

    What is the characteristic CD marker expressed by NK cells?

    <p>CD56</p> Signup and view all the answers

    Which of the following disorders is associated with an increase in the T lymphocyte/CD4:CD8 ratio?

    <p>Multiple sclerosis</p> Signup and view all the answers

    What is the primary T lymphocyte antigen receptor called?

    <p>T cell receptor (TCR)</p> Signup and view all the answers

    Which subset of T cells are defined by the expression of TCR with α and β chains?

    <p>αβ T cells</p> Signup and view all the answers

    What characterizes mature NK cells in terms of CD56 and CD16 levels and cytolytic activity?

    <p>Low CD56, high CD16, potent lytic activity</p> Signup and view all the answers

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