18 Questions
Where are NK progenitors and immature cells found?
Bone marrow
What is the primary function of Natural Killer (NK) cells?
Kill tumor cells and virus-infected cells
What percentage of circulating lymphocytes do NK cells typically constitute?
5–20%
Which molecule is produced by lymphocytes and plasma cells, and is known as antibody in its secreted form?
Immunoglobulin (Ig)
What is the lifespan of most NK cells after viral exposure?
A few days to a few weeks
Which cell surface markers are used to differentiate developmental stages of B precursor cells?
CD19 and/or CD20
Which major gene loci are involved in Class II MHC molecules?
HLA-DP, HLA-DQ, HLA-DR
Which type of T cells are MHC Class I molecules primarily presenting antigens to?
T cytotoxic cells (CD8+ T cells)
What is the role of Natural Killer (NK) cells in innate immune responses?
Releasing cytokines to activate macrophages
How do MHC Class II molecules present antigens to immune cells?
With peptides from intracellular pathogens to CD4+ T cells
Which molecules do NK cells recognize on infected cells or stressed cells?
MHC Class I molecules
Which type of T cell co-receptor is involved in binding with antigens/MHC during T cell activation?
CD4
Which population of lymphoid cells were first identified as cytotoxic cells capable of killing tumor cells and virus-infected cells in the absence of immune sensitization?
NK cells
What is the characteristic CD marker expressed by NK cells?
CD56
Which of the following disorders is associated with an increase in the T lymphocyte/CD4:CD8 ratio?
Multiple sclerosis
What is the primary T lymphocyte antigen receptor called?
T cell receptor (TCR)
Which subset of T cells are defined by the expression of TCR with α and β chains?
αβ T cells
What characterizes mature NK cells in terms of CD56 and CD16 levels and cytolytic activity?
Low CD56, high CD16, potent lytic activity
Test your knowledge on the Class II gene loci, function of T lymphocytes, and how MHC Class I and II molecules present antigens to T cells. Identify key concepts related to the Major Histocompatibility Complex.
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