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Questions and Answers
What type of chromosomal rearrangement produces a hybrid gene encoding a fusion protein with constitutive activity?
What type of chromosomal rearrangement produces a hybrid gene encoding a fusion protein with constitutive activity?
- Gain-of-function mutation (correct)
- Amplification of a DNA segment
- Production of oncoproteins
- Alteration in the ras gene
Which mechanism involves the inappropriate overproduction of a growth-regulatory gene due to changes in its promoter?
Which mechanism involves the inappropriate overproduction of a growth-regulatory gene due to changes in its promoter?
- Alteration in the ras gene
- Generation of oncoproteins
- Chromosomal rearrangement producing a hybrid gene
- Amplification of a DNA segment (correct)
What is the main function of the Ras protein in regulating cell growth and differentiation?
What is the main function of the Ras protein in regulating cell growth and differentiation?
- Promoting cell death
- Binding and breaking up GTP molecules (correct)
- Activating tumor suppressor genes
- Inhibiting cell division
Which genetic alteration in the Ras gene reduces its GTPase activity and affects its ability to break up GTP molecules?
Which genetic alteration in the Ras gene reduces its GTPase activity and affects its ability to break up GTP molecules?
In CML, which genetic abnormality leads to the formation of the Philadelphia chromosome?
In CML, which genetic abnormality leads to the formation of the Philadelphia chromosome?
What is Imatinib mesylate commonly used for in the treatment of CML?
What is Imatinib mesylate commonly used for in the treatment of CML?
Which of the following leads to the production of oncoproteins that are different from their normal counterparts?
Which of the following leads to the production of oncoproteins that are different from their normal counterparts?
'Alterations in the ras gene reduce its GTPase activity' is an example of what type of genetic change?
'Alterations in the ras gene reduce its GTPase activity' is an example of what type of genetic change?
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