8 Questions
What type of chromosomal rearrangement produces a hybrid gene encoding a fusion protein with constitutive activity?
Gain-of-function mutation
Which mechanism involves the inappropriate overproduction of a growth-regulatory gene due to changes in its promoter?
Amplification of a DNA segment
What is the main function of the Ras protein in regulating cell growth and differentiation?
Binding and breaking up GTP molecules
Which genetic alteration in the Ras gene reduces its GTPase activity and affects its ability to break up GTP molecules?
Gain-of-function mutation
In CML, which genetic abnormality leads to the formation of the Philadelphia chromosome?
Chromosomal rearrangement producing a hybrid gene
What is Imatinib mesylate commonly used for in the treatment of CML?
Targeting abnormal fusion proteins
Which of the following leads to the production of oncoproteins that are different from their normal counterparts?
Chromosomal rearrangement producing a hybrid gene
'Alterations in the ras gene reduce its GTPase activity' is an example of what type of genetic change?
Gain-of-function mutation
Test your knowledge on CTLA-4 and PD-1 pathways, their similarities, differences, and implications of their inhibition in immunology and oncology. The quiz content references a case of an 11-year-old boy with jaw swelling for evaluation.
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