Immunoglobulin Structure and Function
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Questions and Answers

Which region of the antibody is responsible for modulating immune cell activity?

  • Constant domain
  • Hinge region
  • Variable domain
  • Fc region (correct)

    • What is the role of the hinge region in an antibody?

  • Determining heavy chain isotypes
  • Modulating immune cell activity
  • Binding to Fc receptors
  • Providing flexibility between CH1 and CH2 domains (correct)

    • Which type of determinants arise from the sequence of heavy and light chain variable regions?

  • Isotypic determinants
  • Allotypic determinants
  • Idiotypic determinants (correct)
  • Constant-region determinants

    • What defines each heavy-chain class and subclass within a species?

    <p>Constant-region determinants</p> Signup and view all the answers

    Which region of IgG1 is freely flexible and encompasses amino acids 216-231?

    <p>Hinge region</p> Signup and view all the answers

    What is the main function of immunoglobulin in the immune system?

    <p>Identify and neutralize foreign objects</p> Signup and view all the answers

    Which part of the antibody contains a paratope that binds to a specific epitope on an antigen?

    <p>Variable region</p> Signup and view all the answers

    What is the function of the Fab region of an antibody?

    <p>Recognize specific antigens</p> Signup and view all the answers

    What is the role of hypervariable regions within an antibody?

    <p>Directly contact part of the antigen's surface</p> Signup and view all the answers

    What happens when an antibody is treated with a protease?

    <p>The antibody loses its Y-shape</p> Signup and view all the answers

    What is the role of the hypervariable regions in an antibody?

    <p>They directly contact a portion of the antigen's surface.</p> Signup and view all the answers

    How does the hinge region in an antibody contribute to its function?

    <p>It allows flexibility for the arms of the Y-shaped antibody.</p> Signup and view all the answers

    What happens when an antibody is treated with a protease?

    <p>The Fab region is produced, including the variable ends of the antibody.</p> Signup and view all the answers

    Which region of an antibody is referred to as the complementarity determining regions, or CDRs?

    <p>Hypervariable regions</p> Signup and view all the answers

    What role does the constant sequence of amino acids play in an antibody?

    <p>Connects heavy and light chains through disulfide bonds.</p> Signup and view all the answers

    What defines the variant forms of an Ig molecule produced due to allelic variation in the Ig-specifying genes?

    <p>Allotypic determinants</p> Signup and view all the answers

    Which antibody subclass shows over 95% homology in the amino acid sequences of the constant domains of the γ-heavy chains?

    <p>IgG1</p> Signup and view all the answers

    Which region of the antibody is composed of two heavy chains contributing two or three constant domains depending on the antibody class?

    <p>Fc region</p> Signup and view all the answers

    Which light chain isotype is expressed by humans along with the κ light chain?

    <p>λ</p> Signup and view all the answers

    In humans, which isotype has heavy chains designated as α?

    <p>IgA 1, 2</p> Signup and view all the answers

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