Podcast
Questions and Answers
Which region of the antibody is responsible for modulating immune cell activity?
Which region of the antibody is responsible for modulating immune cell activity?
- Constant domain
- Hinge region
- Variable domain
- Fc region (correct)
What is the role of the hinge region in an antibody?
What is the role of the hinge region in an antibody?
- Determining heavy chain isotypes
- Modulating immune cell activity
- Binding to Fc receptors
- Providing flexibility between CH1 and CH2 domains (correct)
Which type of determinants arise from the sequence of heavy and light chain variable regions?
Which type of determinants arise from the sequence of heavy and light chain variable regions?
- Isotypic determinants
- Allotypic determinants
- Idiotypic determinants (correct)
- Constant-region determinants
What defines each heavy-chain class and subclass within a species?
What defines each heavy-chain class and subclass within a species?
Which region of IgG1 is freely flexible and encompasses amino acids 216-231?
Which region of IgG1 is freely flexible and encompasses amino acids 216-231?
What is the main function of immunoglobulin in the immune system?
What is the main function of immunoglobulin in the immune system?
Which part of the antibody contains a paratope that binds to a specific epitope on an antigen?
Which part of the antibody contains a paratope that binds to a specific epitope on an antigen?
What is the function of the Fab region of an antibody?
What is the function of the Fab region of an antibody?
What is the role of hypervariable regions within an antibody?
What is the role of hypervariable regions within an antibody?
What happens when an antibody is treated with a protease?
What happens when an antibody is treated with a protease?
What is the role of the hypervariable regions in an antibody?
What is the role of the hypervariable regions in an antibody?
How does the hinge region in an antibody contribute to its function?
How does the hinge region in an antibody contribute to its function?
What happens when an antibody is treated with a protease?
What happens when an antibody is treated with a protease?
Which region of an antibody is referred to as the complementarity determining regions, or CDRs?
Which region of an antibody is referred to as the complementarity determining regions, or CDRs?
What role does the constant sequence of amino acids play in an antibody?
What role does the constant sequence of amino acids play in an antibody?
What defines the variant forms of an Ig molecule produced due to allelic variation in the Ig-specifying genes?
What defines the variant forms of an Ig molecule produced due to allelic variation in the Ig-specifying genes?
Which antibody subclass shows over 95% homology in the amino acid sequences of the constant domains of the γ-heavy chains?
Which antibody subclass shows over 95% homology in the amino acid sequences of the constant domains of the γ-heavy chains?
Which region of the antibody is composed of two heavy chains contributing two or three constant domains depending on the antibody class?
Which region of the antibody is composed of two heavy chains contributing two or three constant domains depending on the antibody class?
Which light chain isotype is expressed by humans along with the κ light chain?
Which light chain isotype is expressed by humans along with the κ light chain?
In humans, which isotype has heavy chains designated as α?
In humans, which isotype has heavy chains designated as α?
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