Immunoglobulin Structure and Function

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Which region of the antibody is responsible for modulating immune cell activity?

Constant domain

Hinge region

Variable domain

Fc region (correct)

What is the role of the hinge region in an antibody?

Determining heavy chain isotypes

Modulating immune cell activity

Binding to Fc receptors

Providing flexibility between CH1 and CH2 domains (correct)

Which type of determinants arise from the sequence of heavy and light chain variable regions?

Isotypic determinants

Allotypic determinants

Idiotypic determinants (correct)

Constant-region determinants

What defines each heavy-chain class and subclass within a species?

Constant-region determinants Signup and view all the answers

Which region of IgG1 is freely flexible and encompasses amino acids 216-231?

Hinge region Signup and view all the answers

What is the main function of immunoglobulin in the immune system?

Identify and neutralize foreign objects Signup and view all the answers

Which part of the antibody contains a paratope that binds to a specific epitope on an antigen?

Variable region Signup and view all the answers

What is the function of the Fab region of an antibody?

Recognize specific antigens Signup and view all the answers

What is the role of hypervariable regions within an antibody?

Directly contact part of the antigen's surface Signup and view all the answers

What happens when an antibody is treated with a protease?

The antibody loses its Y-shape Signup and view all the answers

What is the role of the hypervariable regions in an antibody?

They directly contact a portion of the antigen's surface. Signup and view all the answers

How does the hinge region in an antibody contribute to its function?

It allows flexibility for the arms of the Y-shaped antibody. Signup and view all the answers

What happens when an antibody is treated with a protease?

The Fab region is produced, including the variable ends of the antibody. Signup and view all the answers

Which region of an antibody is referred to as the complementarity determining regions, or CDRs?

Hypervariable regions Signup and view all the answers

What role does the constant sequence of amino acids play in an antibody?

Connects heavy and light chains through disulfide bonds. Signup and view all the answers

What defines the variant forms of an Ig molecule produced due to allelic variation in the Ig-specifying genes?

Allotypic determinants Signup and view all the answers

Which antibody subclass shows over 95% homology in the amino acid sequences of the constant domains of the γ-heavy chains?

IgG1 Signup and view all the answers

Immunoglobulin Structure and Function

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Questions and Answers

Which region of the antibody is responsible for modulating immune cell activity?

What is the role of the hinge region in an antibody?

Which type of determinants arise from the sequence of heavy and light chain variable regions?

What defines each heavy-chain class and subclass within a species?

Which region of IgG1 is freely flexible and encompasses amino acids 216-231?

What is the main function of immunoglobulin in the immune system?

Which part of the antibody contains a paratope that binds to a specific epitope on an antigen?

What is the function of the Fab region of an antibody?

What is the role of hypervariable regions within an antibody?

What happens when an antibody is treated with a protease?

What is the role of the hypervariable regions in an antibody?

How does the hinge region in an antibody contribute to its function?

What happens when an antibody is treated with a protease?

Which region of an antibody is referred to as the complementarity determining regions, or CDRs?

What role does the constant sequence of amino acids play in an antibody?

What defines the variant forms of an Ig molecule produced due to allelic variation in the Ig-specifying genes?

Which antibody subclass shows over 95% homology in the amino acid sequences of the constant domains of the γ-heavy chains?

Which region of the antibody is composed of two heavy chains contributing two or three constant domains depending on the antibody class?

Which light chain isotype is expressed by humans along with the κ light chain?

In humans, which isotype has heavy chains designated as α?

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