Immuno-Chemistry Course (Bio-4218) Theoretical Part Lecture 5 Quiz

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Where are Class II MHC molecules mainly expressed?

Neurons

Dendritic cells, macrophages, and B lymphocytes (correct)

All nucleated cells

Red blood cells

How many different HLA proteins are estimated to exist in total?

Less than 1,000

Exactly 10,000

More than 14,000 (correct)

Around 5,000

What makes MHC molecules the most polymorphic of all proteins in mammals?

The great polymorphism resulting from numerous variants (correct)

Their expression only on immune cells

Being inherited only from one parent

Being the largest proteins in mammals

What does it mean that MHC genes are codominantly expressed?

Alleles inherited from both parents are expressed equally Signup and view all the answers

How are antigen receptors different from MHC proteins in terms of generation?

MHC proteins are inherited, while antigen receptors are generated de novo by somatic gene recombination Signup and view all the answers

What does the term 'histocompatibility' used to describe in the context of MHC system?

Their function in transplantation reactions Signup and view all the answers

Where is the Human Leukocyte Antigen (HLA) system located in humans?

Chromosome 6p21.3 Signup and view all the answers

What signals that a cell is healthy according to the text?

Expression of self-MHC class I with self peptides Signup and view all the answers

Which cells target a cell for killing in the absence of self-MHC class I according to the text?

NK cells Signup and view all the answers

What type of peptides do our cells present in the groove of MHC class I molecules?

Self-peptides Signup and view all the answers

Which gene cluster in the human genome contains the most polymorphic genes?

Chromosome 6 Signup and view all the answers

What is the function of the peptide-binding cleft in class I MHC molecules?

To accommodate peptides typically 8 to 9 amino acids long Signup and view all the answers

Which domain of class I MHC molecules contains a site that binds the CD8+ T cell coreceptor?

α3 domain Signup and view all the answers

What is the function of the α2 and β2 domains in class II MHC molecules?

To contain the binding site for the CD4+ T cell coreceptor Signup and view all the answers

What is the typical length of peptides that can be accommodated in the peptide-binding cleft of class II MHC molecules?

10 to 30 amino acids Signup and view all the answers

Which domains of class I and class II MHC molecules are polymorphic, meaning they exhibit variations in their amino acid sequences?

α1 and α2 domains in class I, α1 and β1 domains in class II Signup and view all the answers

Which structural feature classifies MHC molecules as members of the immunoglobulin superfamily?

The membrane-proximal domains possessing the immunoglobulin-fold structure Signup and view all the answers

Immuno-Chemistry Course (Bio-4218) Theoretical Part Lecture 5 Quiz

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