Immuno-Chemistry Course (Bio-4218) Theoretical Part Lecture 5 Quiz
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Questions and Answers

Where are Class II MHC molecules mainly expressed?

  • Neurons
  • Dendritic cells, macrophages, and B lymphocytes (correct)
  • All nucleated cells
  • Red blood cells

    • How many different HLA proteins are estimated to exist in total?

  • Less than 1,000
  • Exactly 10,000
  • More than 14,000 (correct)
  • Around 5,000

    • What makes MHC molecules the most polymorphic of all proteins in mammals?

  • The great polymorphism resulting from numerous variants (correct)
  • Their expression only on immune cells
  • Being inherited only from one parent
  • Being the largest proteins in mammals

    • What does it mean that MHC genes are codominantly expressed?

    <p>Alleles inherited from both parents are expressed equally</p> Signup and view all the answers

    How are antigen receptors different from MHC proteins in terms of generation?

    <p>MHC proteins are inherited, while antigen receptors are generated de novo by somatic gene recombination</p> Signup and view all the answers

    What does the term 'histocompatibility' used to describe in the context of MHC system?

    <p>Their function in transplantation reactions</p> Signup and view all the answers

    Where is the Human Leukocyte Antigen (HLA) system located in humans?

    <p>Chromosome 6p21.3</p> Signup and view all the answers

    What signals that a cell is healthy according to the text?

    <p>Expression of self-MHC class I with self peptides</p> Signup and view all the answers

    Which cells target a cell for killing in the absence of self-MHC class I according to the text?

    <p>NK cells</p> Signup and view all the answers

    What type of peptides do our cells present in the groove of MHC class I molecules?

    <p>Self-peptides</p> Signup and view all the answers

    Which gene cluster in the human genome contains the most polymorphic genes?

    <p>Chromosome 6</p> Signup and view all the answers

    What is the function of the peptide-binding cleft in class I MHC molecules?

    <p>To accommodate peptides typically 8 to 9 amino acids long</p> Signup and view all the answers

    Which domain of class I MHC molecules contains a site that binds the CD8+ T cell coreceptor?

    <p>α3 domain</p> Signup and view all the answers

    What is the function of the α2 and β2 domains in class II MHC molecules?

    <p>To contain the binding site for the CD4+ T cell coreceptor</p> Signup and view all the answers

    What is the typical length of peptides that can be accommodated in the peptide-binding cleft of class II MHC molecules?

    <p>10 to 30 amino acids</p> Signup and view all the answers

    Which domains of class I and class II MHC molecules are polymorphic, meaning they exhibit variations in their amino acid sequences?

    <p>α1 and α2 domains in class I, α1 and β1 domains in class II</p> Signup and view all the answers

    Which structural feature classifies MHC molecules as members of the immunoglobulin superfamily?

    <p>The membrane-proximal domains possessing the immunoglobulin-fold structure</p> Signup and view all the answers

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