Podcast
Questions and Answers
Where are Class II MHC molecules mainly expressed?
Where are Class II MHC molecules mainly expressed?
- Neurons
- Dendritic cells, macrophages, and B lymphocytes (correct)
- All nucleated cells
- Red blood cells
How many different HLA proteins are estimated to exist in total?
How many different HLA proteins are estimated to exist in total?
- Less than 1,000
- Exactly 10,000
- More than 14,000 (correct)
- Around 5,000
What makes MHC molecules the most polymorphic of all proteins in mammals?
What makes MHC molecules the most polymorphic of all proteins in mammals?
- The great polymorphism resulting from numerous variants (correct)
- Their expression only on immune cells
- Being inherited only from one parent
- Being the largest proteins in mammals
What does it mean that MHC genes are codominantly expressed?
What does it mean that MHC genes are codominantly expressed?
How are antigen receptors different from MHC proteins in terms of generation?
How are antigen receptors different from MHC proteins in terms of generation?
What does the term 'histocompatibility' used to describe in the context of MHC system?
What does the term 'histocompatibility' used to describe in the context of MHC system?
Where is the Human Leukocyte Antigen (HLA) system located in humans?
Where is the Human Leukocyte Antigen (HLA) system located in humans?
What signals that a cell is healthy according to the text?
What signals that a cell is healthy according to the text?
Which cells target a cell for killing in the absence of self-MHC class I according to the text?
Which cells target a cell for killing in the absence of self-MHC class I according to the text?
What type of peptides do our cells present in the groove of MHC class I molecules?
What type of peptides do our cells present in the groove of MHC class I molecules?
Which gene cluster in the human genome contains the most polymorphic genes?
Which gene cluster in the human genome contains the most polymorphic genes?
What is the function of the peptide-binding cleft in class I MHC molecules?
What is the function of the peptide-binding cleft in class I MHC molecules?
Which domain of class I MHC molecules contains a site that binds the CD8+ T cell coreceptor?
Which domain of class I MHC molecules contains a site that binds the CD8+ T cell coreceptor?
What is the function of the α2 and β2 domains in class II MHC molecules?
What is the function of the α2 and β2 domains in class II MHC molecules?
What is the typical length of peptides that can be accommodated in the peptide-binding cleft of class II MHC molecules?
What is the typical length of peptides that can be accommodated in the peptide-binding cleft of class II MHC molecules?
Which domains of class I and class II MHC molecules are polymorphic, meaning they exhibit variations in their amino acid sequences?
Which domains of class I and class II MHC molecules are polymorphic, meaning they exhibit variations in their amino acid sequences?
Which structural feature classifies MHC molecules as members of the immunoglobulin superfamily?
Which structural feature classifies MHC molecules as members of the immunoglobulin superfamily?
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