Immunity Basics and Types

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Questions and Answers

The complement is a family of more than twenty different proteins in serum that function as a non-specific defense against ______.

infection

Interferons are small proteins produced by eukaryotic cells in response to ______ infection.

viral

Alveolar macrophages, along with neutrophils and natural killer cells, remove particles and organisms that enter the ______.

alveoli

Normal flora refers to the large number of microorganisms in the human body that are generally ______.

<p>harmless</p> Signup and view all the answers

The inflammatory response is the vascular and cellular reaction to the presence of invading microorganisms or ______.

<p>injury</p> Signup and view all the answers

The process of inflammation may be divided into several stages, including initiation, tissue response, leukocyte response, and ______.

<p>tissue repair</p> Signup and view all the answers

Damaged cells at the site of injury release chemical factors such as ______, which trigger vasodilatation.

<p>histamine</p> Signup and view all the answers

Phagocytic cells accomplish the leukocyte response by ______ the microbes and damaged tissue.

<p>engulfing</p> Signup and view all the answers

Blood clots around the site prevent the microbe or its products from spreading to the other part of the ______.

<p>body</p> Signup and view all the answers

Some individuals of the same race and same species can have varied experiences with certain ______.

<p>infections</p> Signup and view all the answers

Very old people and young ones are more susceptible to infections when compared to ______.

<p>adults</p> Signup and view all the answers

Any individual under corticosteroid hormone treatment is more susceptible to ______.

<p>infection</p> Signup and view all the answers

Individuals of different races within the same species have varied susceptibility or resistance toward ______.

<p>infection</p> Signup and view all the answers

Sickle cell anaemia causes an alteration of the shape of the ______, which prevents its parasitisation.

<p>erythrocyte</p> Signup and view all the answers

Physical and chemical barriers prevent the entry of foreign ______.

<p>materials</p> Signup and view all the answers

Gastric acidity, whose high pH prevents the entry of pathogens inside the body by ______ effect.

<p>microbicidal</p> Signup and view all the answers

Immunity can be defined as the way in which the body can protect itself from invasion by pathogenic ______.

<p>microorganisms</p> Signup and view all the answers

The reaction to foreign substances is described as ______.

<p>inflammation</p> Signup and view all the answers

Non-specific immunity is also called ______ immunity.

<p>natural</p> Signup and view all the answers

The two major groups of immunity are non specific immunity and ______ immunity.

<p>specific</p> Signup and view all the answers

The unbroken skin and mucus membrane serve as effective mechanical barriers to infectious ______.

<p>agents</p> Signup and view all the answers

Maternal passive immunity is antibody-mediated immunity that is passed to the fetus through the ______.

<p>placenta</p> Signup and view all the answers

Keratin is a skin ______ produced by the outermost cells of the skin.

<p>protein</p> Signup and view all the answers

The only antibody isotype that can pass through the placenta is ______.

<p>IgG</p> Signup and view all the answers

Hydrochloric acid and bile salt inhibit the growth of microorganisms in the gastrointestinal ______.

<p>tract</p> Signup and view all the answers

Passive immunity can also be provided through the transfer of IgA antibodies found in ______ milk.

<p>breast</p> Signup and view all the answers

Mucous production and ciliary movement protect the ______ cavity and throat.

<p>nasal</p> Signup and view all the answers

Colostrum present in mother's milk is an example of ______ immunity.

<p>passive</p> Signup and view all the answers

The action of ______ removes mucus that contains microorganisms from the respiratory tract.

<p>coughing</p> Signup and view all the answers

The soft, spongy tissue found in bone cavities is known as ______.

<p>bone marrow</p> Signup and view all the answers

Tears wash the conjunctiva and perform a similar defensive function as the urine in the ______.

<p>urethra</p> Signup and view all the answers

Lysozyme is an enzyme that can break down the cell wall of ______-positive bacteria.

<p>Gram</p> Signup and view all the answers

Flashcards

Non-Specific Immunity

The body's natural defense against pathogens. It's like a general, non-specific army, acting quickly to fight off any invaders.

Specific Immunity

A type of immunity specifically targeting particular pathogens. It's like a trained army, remembering enemies and fighting them effectively.

Maternal Passive Immunity

Antibodies from the mother transferred to the baby during pregnancy. It's like a temporary protection until the baby can build its own immunity.

Breast milk Immunity

Antibodies passed from mother to baby through breastfeeding. This provides early protection to the infant's gut.

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Immune Self-Recognition

The ability of the body to distinguish between 'self' (its own cells) and 'non-self' (foreign invaders).

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Inflammation

The body's reaction to a foreign substance, like an invader, often causing redness, swelling, and pain.

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Immune Tolerance

The lack of an immune response to 'self' substances. It prevents the immune system from attacking its own body cells.

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Immune Homeostasis

A state of health achieved when the immune system effectively eliminates foreign substances while sparing 'self' cells.

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Keratin

Tough, water-resistant protein in the skin. It makes the skin dry, creating an unfriendly environment for most microorganisms.

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Lysozyme

A chemical in tears and other body fluids that breaks down the cell walls of certain bacteria.

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Physical or mechanical barrier

A defense mechanism involving physical barriers like skin and mucus membranes, which block pathogens from entering the body.

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Hydrochloric acid

A chemical secreted by the stomach that breaks down food and kills most harmful bacteria.

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Bile salt

A substance produced by the liver that aids in digestion and helps eliminate bacteria in the gut.

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Ciliary movement

The movement of tiny hair-like projections that move mucus containing trapped microorganisms towards the mouth.

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Mucus

A sticky substance that traps microorganisms and helps prevent infections. Found in the nose, throat, and other areas.

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Complement system

A family of proteins in the blood that act as a general defense against infections, recognizing and targeting invaders without specificity.

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Interferons

Small proteins produced by cells in response to viral infection. Interferons signal nearby cells to produce antiviral molecules, preventing further viral spread.

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Alveolar macrophages

Cells that engulf and destroy foreign particles and pathogens, acting as the first line of defense in the alveoli.

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Neutrophils

White blood cells that readily migrate to sites of infection and engulf microbes, playing a crucial role in early immune response.

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Natural killer cells

Large lymphocytes that specifically target and eliminate abnormal or infected cells, including tumor cells and virus-infected cells.

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Normal flora

The community of microorganisms that normally reside in the human body, generally harmless and beneficial. They help prevent the growth of pathogens by competing for resources and space.

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Inflammatory response

The body's complex, multi-stage response to injury or infection, characterized by redness, swelling, heat, and pain.

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Tissue Response in Inflammation

The release of chemical factors like histamine from damaged cells, triggering vasodilation and increased capillary permeability, allowing immune cells to reach the site of injury.

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Individual Immunity

The varied susceptibility of individuals within the same race and species towards infections. For example, children are more prone to viral fever than adults.

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Racial Immunity

Differences in susceptibility to infections based on race or ethnicity, despite being in the same species. For example, people with sickle cell anemia are more resistant to malaria.

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Species Immunity

Differences in susceptibility to infections across species. For example, humans are not affected by chicken cholera, but animals are resistant to human diseases like measles.

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What is the primary function of innate immunity?

The body's initial line of defense against pathogens, involving physical and chemical barriers. It's like a wall or barrier preventing invaders from entering.

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What happens in innate immunity when infections are established?

A powerful defense mechanism activated when pathogens bypass the initial barriers. It involves complement reactions and phagocytosis, helping to clear out invaders. It's like a coordinated attack team.

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How does innate immunity contribute to adaptive immunity?

The ability of innate immunity to activate the adaptive immune system. It does this by releasing signaling molecules (cytokines) and presenting antigens to the adaptive system. It's like a messenger calling for reinforcements.

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Give an example of innate immunity- gastric acidity

The high acidity of gastric juices, which prevents the entry of pathogens by killing them. It's like an acidic bath that destroys harmful invaders.

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Study Notes

Immunity Definition

  • Immunity is the body's defense mechanisms against pathogens and harmful effects.
  • Reaction to foreign substances is inflammation.
  • Non-reaction to self substances is immunity.
  • Health is a physical state where the self is immunologically spared, and foreign substances are eliminated.
  • Disease arises when foreign substances aren't eliminated, or self-substances aren't spared.

Immunity Types

  • Immunity is classified into two major groups:
    • Innate Immunity: The first line of defense against any infection.
    • Adaptive Immunity: Provides a more specific and targeted response.

Innate Components

  • Adenoids: Two glands located in the nasal passage
  • Bone Marrow: Soft, spongy tissue found in bone cavities
  • Lymph Nodes: Small bean-shaped organs throughout the body, connected by lymphatic vessels.
  • Lymphatic Vessels: A network of channels carrying lymphocytes to lymphoid organs and bloodstream.
  • Peyer Patches: Lymphoid tissue in the small intestine.
  • Spleen: A fist-sized organ located in the abdominal cavity.
  • Thymus: Two lobes in front of the windpipe, behind the breastbone.
  • Tonsils: Two oval masses at the back of the throat.

Non-Specific (Innate) Immunity

  • Physical or Mechanical Barriers: Skin and mucus membranes are essential preventative barriers
    • Low moisture, low pH, secreted inhibitory substances inhibit microbial growth.
  • Biochemical Factors: Chemical secretions inhibiting microbial growth.
    • Keratin (skin protein) creates a dry environment.
  • Cellular Mechanisms:
    • Alveolar macrophages and neutrophils phagocytize microbes.
    • Natural killer cells kill undesirable cells (tumors, viruses).
  • Normal Flora: Microorganisms in the body, helping prevent pathogenic organisms.
  • Inflammatory Reactions: A vascular and cellular response to injury or infection.
    • Localized response with increased blood flow, permeability, and cell recruitment.

Types of Innate Immunity

  • Individual Immunity: Variations in susceptibility to infections, based on individual experiences and genetic factors (e.g., age, gender).
  • Racial Immunity: Differences in susceptibility to particular infections based on race.
  • Species Immunity: Differences in susceptibility to specific infections between different species.

Significance of Innate Immunity

  • Physical and chemical barriers prevent foreign material entry.
  • Complement reactions and phagocytosis clear infections.
  • Activates the adaptive immune response.
  • Examples include gastric acidity, skin as a barrier.

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Lecture 3: Immunity (PDF)

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