Immune System: Secondary Immune Sites

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Questions and Answers

What is one advantage of the innate immune system?

  • It can act quickly as the first line of defense. (correct)
  • It produces antibodies upon first exposure.
  • It has a memory that improves responses to repeated infections.
  • It recognizes specific pathogens.

What is a key feature of the adaptive immune system?

  • It is responsible for the initial inflammatory response.
  • It lacks specialized receptors for antigens.
  • It responds immediately to all pathogens.
  • It improves its response time with repeated exposure. (correct)

Which type of immune cells are classified as granulocytes?

  • Cells that primarily respond to DNA fragments.
  • Cells that have a memory response.
  • Cells filled with granules containing toxins. (correct)
  • Cells that produce antibodies.

How does the innate immune system differ from the adaptive immune system?

<p>It does not have memory and cannot improve its response. (C)</p> Signup and view all the answers

What role do Toll-like receptors play in the immune system?

<p>They help recognize bacterial components. (D)</p> Signup and view all the answers

Which of the following correctly describes the function of the spleen?

<p>It cleans blood of debris, especially dead cells. (B)</p> Signup and view all the answers

What is the primary role of lymph nodes in the immune system?

<p>They serve as collection points for lymphatic fluid. (D)</p> Signup and view all the answers

Which of the following structures is involved in checking food for pathogens?

<p>Tonsils (C)</p> Signup and view all the answers

What do Peyer's patches primarily contain?

<p>Clusters of immune cells (D)</p> Signup and view all the answers

What differentiates the innate immune system from the acquired immune system?

<p>Innate immunity is based on innate recognition of PAMPS. (D)</p> Signup and view all the answers

Which statement about lymph is correct?

<p>Lymph is a clear liquid derived from blood without red blood cells. (C)</p> Signup and view all the answers

Where in the body do adenoids function primarily?

<p>In the respiratory tract for air monitoring. (C)</p> Signup and view all the answers

What do PAMPS stand for in the context of the immune response?

<p>Pathogen Associated Molecular Patterns (B)</p> Signup and view all the answers

What is the primary function of neutrophilic granulocytes?

<p>To undergo phagocytosis and engulf bacteria (D)</p> Signup and view all the answers

Which type of white blood cell is responsible for secreting histamine?

<p>Basophil (D)</p> Signup and view all the answers

What role do eosinophils specifically play in the immune system?

<p>They are responsible for killing large parasites (A)</p> Signup and view all the answers

What happens during anaphylactic shock regarding histamine release?

<p>Too much histamine is released, leading to a drop in blood pressure (D)</p> Signup and view all the answers

Which white blood cell is most common in the human body?

<p>Neutrophilic granulocyte (C)</p> Signup and view all the answers

What major function does the Major Histocompatibility Complex (MHC) serve in the immune system?

<p>To present antigens to immune cells (D)</p> Signup and view all the answers

What triggers vasodilation in the vascular system during an immune response?

<p>Histamine secreted by basophils (D)</p> Signup and view all the answers

What mechanism do neutrophilic granulocytes primarily use to destroy pathogens?

<p>Phagocytosis (C)</p> Signup and view all the answers

Which immune system component is responsible for binding tightly to antigens?

<p>Adaptive immune cells (C)</p> Signup and view all the answers

What do innate immune cells have that allows them to respond rapidly?

<p>Specialized receptors (A)</p> Signup and view all the answers

Which statement best describes the function of granulocytes in the immune system?

<p>They store poison to combat pathogens. (C)</p> Signup and view all the answers

What is a characteristic feature of the adaptive immune system compared to the innate immune system?

<p>It recognizes specific antigens to mount a response. (B)</p> Signup and view all the answers

What function does the spleen have in the immune system?

<p>Cleans blood of debris, particularly dead red blood cells (B)</p> Signup and view all the answers

What is the primary function of lymph nodes?

<p>Filter lymph and collect immune cells (C)</p> Signup and view all the answers

How do the tonsils contribute to immune function?

<p>They check food for pathogens (C)</p> Signup and view all the answers

What do Peyer's patches primarily consist of?

<p>Clusters of immune cells (B)</p> Signup and view all the answers

Which component of the immune system is present at birth and provides a rapid response?

<p>Innate immunity (D)</p> Signup and view all the answers

What do Pathogen-Associated Molecular Patterns (PAMPs) help the immune system to recognize?

<p>Pathogens (C)</p> Signup and view all the answers

What characteristic is true of lymph?

<p>Is derived from blood but has no red blood cells (D)</p> Signup and view all the answers

Which system is involved in checking air for pathogens?

<p>Adenoids (C)</p> Signup and view all the answers

What is the primary action performed by neutrophilic granulocytes?

<p>Phagocytosis of pathogens (B)</p> Signup and view all the answers

Which cell type is responsible for secreting histamine during an immune response?

<p>Basophils (C)</p> Signup and view all the answers

What is the role of eosinophils in the immune system?

<p>Releasing chemicals to kill large parasites (D)</p> Signup and view all the answers

What can occur during anaphylactic shock concerning histamine?

<p>Severe allergic reaction from excessive histamine release (C)</p> Signup and view all the answers

What is the function of the Major Histocompatibility Complex (MHC)?

<p>Presenting antigens to T cells (C)</p> Signup and view all the answers

What is a consequence of histamine secretion by basophils?

<p>Increased blood flow and vasodilation (A)</p> Signup and view all the answers

What happens to blood pressure during an anaphylactic shock?

<p>It drops sharply (C)</p> Signup and view all the answers

What is the primary mechanism through which neutrophils destroy pathogens?

<p>Engulfing and digesting through phagocytosis (B)</p> Signup and view all the answers

Flashcards

Immune system sites

Locations where immune responses occur. These include primary and secondary sites.

Spleen Function

The spleen filters blood, removing debris and dead cells, particularly red blood cells.

Lymph nodes

Collection points for immune cells, connected by lymph vessels.

Lymph

Clear liquid derived from blood, but without red blood cells.

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Tonsils

Part of the immune system checking food for pathogens.

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Adenoids

Part of the immune system checking air for pathogens.

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Peyer's patches

Clusters of immune cells in the gut.

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Innate immune system

Part of the immune system present from birth and ready to identify pathogens immediately.

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Adaptive Immune System

The immune system that improves with repeated exposures to pathogens, recognizing specific pathogens.

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Toll-like receptors

Specialized receptors on innate immune cells that recognize bacterial components.

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Granulocytes

Immune cells with granules containing toxins and signals for other immune cells.

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Bacterial cell wall/naked DNA

Components of bacteria recognized by the immune system.

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Neutrophil

A type of white blood cell that is the most common and is responsible for engulfing and destroying bacteria through phagocytosis.

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Phagocytosis

The process of engulfing and digesting foreign particles, such as bacteria, by immune cells.

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Granules

Small sacs within a cell that contain chemicals or enzymes used for immune defense.

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Major Histocompatibility Complex (MHC)

A group of genes that determine the body's immune response and tissue compatibility.

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Eosinophils

White blood cells primarily involved in fighting parasitic infections by releasing chemicals.

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Basophil

A type of white blood cell that releases histamine, causing vasodilation, which helps bring more immune cells to the site of infection.

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Histamine

A chemical released by basophils that causes blood vessels to dilate, increasing blood flow.

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Anaphylactic Shock

A severe allergic reaction caused by a massive release of histamine, leading to a dangerous drop in blood pressure.

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Secondary Immune Sites

Locations in the body where immune cells gather and can encounter pathogens. Examples include the spleen, lymph nodes, tonsils, adenoids, and Peyer's patches.

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What are Lymph Nodes?

Collection points for immune cells, connected by lymph vessels, which are like tiny tubes carrying clear liquid.

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What is Lymph?

Clear liquid derived from blood, but without red blood cells. It travels through lymph vessels.

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Tonsils and Adenoids Function

Check food and air for pathogens, respectively, acting as the first line of defense in the mouth and nose.

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Peyer's Patches Function

Clusters of immune cells in the gut, responsible for checking the food we eat for pathogens.

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What are PAMPS?

Patterns associated with pathogens, recognized by the innate immune system. They signal danger to immune cells.

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What do Granulocytes do?

They fight infections by engulfing foreign particles (phagocytosis) and releasing toxins and signals to other immune cells.

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Neutrophil's Role

Neutrophils are the most common type of white blood cell. They engulf and destroy bacteria through a process called phagocytosis, using their granules to release chemicals and enzymes that kill bacteria.

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Granules in Immune Cells

Granules are small sacs within immune cells that contain toxins and signaling molecules. They help fight off pathogens by releasing their contents to kill or alert other immune cells.

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Eosinophils' Target

Eosinophils are white blood cells that specialize in fighting parasites. They release chemicals to kill parasites that are too large for phagocytosis.

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How Basophils Cause Vasodilation

Basophils release histamine, a chemical that causes blood vessels to widen (vasodilation). This increases blood flow to the area, bringing more immune cells to fight infection.

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MHC: Immune System ID

The Major Histocompatibility Complex (MHC) is a group of genes that determines your unique immune system. It influences how your body reacts to pathogens and determines tissue compatibility.

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What is Epinephrine?

Epinephrine, also known as adrenaline, is a hormone released by the body in stress situations. It helps counter the effects of anaphylactic shock by constricting blood vessels and increasing heart rate.

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Study Notes

Secondary Immune Sites

  • Immune system has primary and secondary sites
  • Secondary sites include the spleen, lymph nodes, tonsils, adenoids, and Peyer's patches
  • These sites encounter pathogens and activate upon pathogen binding

Spleen

  • Cleans blood of debris, like dead cells, particularly red blood cells

Lymph Nodes

  • Collection points for immune cells
  • Connected by lymph vessels (similar to veins with valves)
  • Lymph is clear liquid derived from blood, but without red blood cells

Other Secondary Immune Sites

  • Tonsils (mouth) - check food for pathogens
  • Adenoids (nose) - check air for pathogens
  • Peyer's patches (gut) - clusters of immune cells in the gut

Immune System Branches

  • Two main branches based on function: innate and adaptive
  • Innate: born with, acts fast; recognizes pathogen-associated molecular patterns (PAMPs)
    • PAMPs include parts of bacterial cells (walls, tails, DNA, proteins)
    • Innate immune cells have specialized receptors (toll-like receptors) for PAMPs
    • Advantage: Ready to go; first line of defense
    • Disadvantage: Doesn't remember
  • Adaptive: acquired, acts more slowly; recognizes small protein pieces (antigens) 8-10 amino acids, mounts a response
    • Cells bind tightly to antigens, improve binding over time

Cells of the Immune System (First Group)

  • Granulocytes: granule-filled cells (granules may contain poison and messages for other immune cells)
  • Neutrophils: most common granulocytes, phagocytic, wrap around and destroy other cells

Cells of the Immune System (Other Granulocytes)

  • Eosinophils: secrete chemicals to kill parasites too large for phagocytosis
  • Basophils: secrete histamine which causes vasodilation and brings more blood/immune cells to the area
    • High levels of histamine can cause anaphylactic shock
    • Epinephrine/adrenaline vasoconstricts to counteract the effects of histamine

Immune Cell Function (Example - Phagocytosis)

  • A piece of bacteria is shown to immune cells
  • MHC (major histocompatibility complex)
  • Immune cells destroy the bacteria

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