54 Questions
Which type of drugs block the penetration of viruses into cells?
Immune globulins
Which drugs are used to treat Influenza A and B and inhibit neuraminidase?
Zanamivir, Oseltamivir, Peramivir
Which drug is inhaled and can cause bronchospasm as an adverse effect?
Zanamivir
Which drug is preferred during pregnancy/nursing for treating Influenza A and B?
Oseltamivir
Which drug inhibits the endonuclease activity of the polymerase acidic protein in the viral RNA polymerase complex?
Baloxavir
Which drug is a prodrug to acyclovir and is available orally for the treatment of HSV (herpes simple virus) and VZV (varicellar zoster virus)?
Valacyclovir
Which route of administration is NOT used for acyclovir?
Intramuscular
Which drug is an analog of acyclovir and is used in combination with other drugs for the treatment of herpes infections?
Famciclovir
Which drug is an OTC fusion inhibitor for orolabial HSV?
Docosanol
Which enzyme does acyclovir triphosphate inhibit?
Viral DNA polymerase
What is the mechanism of action of acyclovir triphosphate?
Chain terminator
What is the active form of acyclovir inside cells?
Acyclovir triphosphate
Which drug is a prodrug of penciclovir and is available orally for the treatment of HSV and VZV?
Famciclovir
Which drug is an inhibitor of DNA polymerase, RNA polymerase, and HIV reverse transcriptase? It is used in treatment of cytomegalovirus (CMV) and herpes in acyclovir-resistance.
Foscarnet
Which drug is most nephrotoxic?
Cidofovir
Which drug is associated with bone marrow suppression and anemia as adverse effects?
Ganciclovir
What are the routes of administration for Ganciclovir/Valganciclovir?
IV, intraocular, oral
Which virus does Ribavirin primarily target?
Respiratory Syncytial Virus (RSV)
What is the main adverse effect of Palivizumab?
Increased respiratory tract infections
What is the mechanism of action of Ribavirin?
All of the above
Which drug is used for the prevention of RSV in high-risk children by inhibiting fusion?
Palivizumab
Which drug is associated with an increased risk of respiratory tract infections and gastrointestinal side effects?
Palivizumab
Which type of drugs activate host cell JAK kinases and inhibit viral protein synthesis?
Interferons
Which drug is used for the treatment of chronic hepatitis B and can also inhibit HIV reverse transcriptase?
Tenofovir
Which drug is associated with flu-like symptoms, decreased white blood cell count, and headache as adverse reactions?
Interferons
Which drug inhibits HBV DNA polymerase and is associated with nausea, diarrhea, and nephrotoxicity as adverse effects?
Tenofovir and Entecavir
Which drug is primarily used for the treatment of chronic hepatitis B and HCV and can also be used for malignant melanoma and laryngeal papillomatosis?
Interferons
Which drug is an NS5A protein inhibitor for the treatment of Chronic Hepatitis C?
Ledipasvir, Velpatasvir, and Pibrentasvir (-asvir)
Which drug is an NS3/4 protease inhibitor for the treatment of Chronic Hepatitis C?
Glecaprevir
Which drug is an add-on treatment for genotype 3 Chronic Hepatitis C patients with cirrhosis?
Ribavirin
Which drug is an NS5B RNA polymerase inhibitor for the treatment of Chronic Hepatitis C?
Sofosbuvir and Dasabuvir
Which drug is an add-on treatment for genotype 3 Chronic Hepatitis C patients with cirrhosis?
Ribavirin
Which drug is an IV nucleotide prodrug that inhibits SARS-CoV-2 RNA-dependent RNA polymerase?
Remdesivir
Which drug, when taken orally, inhibits SARS-CoV-2 protein to decrease replication?
Nirmatrelvir
Which drug is commonly associated with adverse effects such as myalgias, taste impairment, increased blood pressure, and diarrhea?
Nirmatrelvir + Ritonavir
Which treatment for HPV warts works by destroying warts through chemical coagulation of proteins?
Trichloroacetic acid
Which treatment for HPV warts works by arresting virus mitosis in metaphase?
Podofilox gel
Which treatment for HPV warts works by stimulating the production of interferon and other cytokines?
Imiquimod cream
Which drug combination is used for Pre-exposure Prophylaxis (PrEP)?
Tenofovir and Emtricitabine
Which drug combination is used for Post-exposure Prophylaxis (PEP)?
Tenofovir & Emtricitabine AND Raltegravir, Dolutegravir, Bictegravir
Which drug class is common to both PrEP and PEP?
rT-inhibitors
Which class of drugs inhibits DNA synthesis via viral reverse transcriptase (RT)?
Reverse transcriptase inhibitors (RTIs)
What are the most frequently used drugs for reverse transcriptase inhibition?
Abacavir/lamivudine; tenofovir/emtricitabine
What are the adverse reactions associated with nucleoside reverse transcriptase inhibitors (NRTIs)?
GI, bone marrow suppression, peripheral neuropathy, lactic acidosis, hypersensitivity
Which class of drugs competitively inhibits HIV protease to inhibit formation of mature viral proteins?
Protease Inhibitors
Which class of drugs prevent the incorporation of viral DNA into host chromosomal DNA to prevent replication?
Integrase Inhibitors
Which drug is a CCR5 co-receptor inhibitor used mostly as an alternative in patients resistant to other treatments?
Maraviroc
Which drug prevents fusion by binding to gp41 protein on the surface of HIV?
Enfuvirtide
Which class of drugs is used mostly as alternatives in patients resistant to other treatments?
Entry Inhibitors
Which class of drugs competitively inhibits HIV reverse transcriptase to prevent the synthesis of viral DNA?
Reverse Transcriptase Inhibitors
Which type of drugs are protease inhibitors?
Drugs that end in -previr and -navir
Which type of drugs are protein inhibitors?
Drugs that end in -asvir
Which type of drugs are RNA polymerase inhibitors?
Drugs that end in -buvir
Which suffix is commonly found in drugs that are integrase inhibitors?
-gravir
"Test your knowledge on immune globulins and antiviral drugs with this quiz! Learn about how immune globulins block virus penetration into cells and explore specific examples like Cilgavimab and Tixagevimab for SARS-CoV
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