Hypocalcemia: Understanding Calcium Levels in the Blood
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Questions and Answers

What is the primary function of calcium in the human body?

  • To facilitate apoptosis in cells
  • To maintain the structure of bones (correct)
  • To transport oxygen throughout the body
  • To regulate the electrical membrane potential in nerve cells

What is the ionized form of calcium in the blood?

  • Ca2+ (correct)
  • Ca+
  • Ca2-
  • Ca3+

What percentage of calcium in the human body is found in bones?

  • 99% (correct)
  • 90%
  • 95%
  • 99.9%

What type of channels are primarily controlled by hormones or neurotransmitters?

<p>Ligand-gated channels (D)</p> Signup and view all the answers

What is the consequence of high levels of intracellular calcium?

<p>Cell death (A)</p> Signup and view all the answers

What is the term for the remaining 1% of calcium in the human body that is not found in bones?

<p>Extracellular calcium (A)</p> Signup and view all the answers

What is the primary cause of low calcium levels in the blood?

<p>Hypoparathyroidism (C)</p> Signup and view all the answers

What is necessary for parathyroid hormone production?

<p>Magnesium (D)</p> Signup and view all the answers

What is the term for the involuntary contraction of muscles due to low calcium levels?

<p>Tetany (C)</p> Signup and view all the answers

What is the effect of low extracellular calcium on voltage-gated sodium channels?

<p>Destabilizing them (C)</p> Signup and view all the answers

What is the diagnosis of hypocalcemia based on?

<p>A low level of calcium in the blood (A)</p> Signup and view all the answers

What is the main goal of treatment in hypocalcemia?

<p>Normalizing calcium levels (B)</p> Signup and view all the answers

What is the term for the twitching of facial muscles after the facial nerve is lightly finger tapped?

<p>Chvostek's sign (B)</p> Signup and view all the answers

What is the term for the muscle spasm that makes the wrist and metacarpophalangeal joints flex?

<p>Trousseau's sign (B)</p> Signup and view all the answers

What is the effect of ionized calcium binding to phosphate?

<p>Decreasing calcium levels (C)</p> Signup and view all the answers

What is the result of too many blood transfusions on ionized calcium levels?

<p>A decrease in ionized calcium (D)</p> Signup and view all the answers

What is the primary function of ATP-dependent calcium pumps in cells?

<p>To prevent calcium levels from getting too high (D)</p> Signup and view all the answers

Where is the majority of intracellular calcium stored?

<p>Mitochondria and smooth endoplasmic reticulum (A)</p> Signup and view all the answers

What is the function of the calcium-sensing receptor in parathyroid cells?

<p>To detect changes in extracellular calcium levels (B)</p> Signup and view all the answers

What is the purpose of parathyroid hormone released by the parathyroid gland?

<p>To release calcium from bones and kidneys (A)</p> Signup and view all the answers

What is the effect of high pH (alkalosis) on albumin and calcium levels in the blood?

<p>Decreased free-ionized calcium and increased bound calcium (A)</p> Signup and view all the answers

What is the term for the condition in which total calcium levels appear low due to low albumin levels, but free-ionized calcium levels are normal?

<p>Pseudohypocalcemia (B)</p> Signup and view all the answers

What is the purpose of complexed calcium in the blood?

<p>To neutralize the electrical charge of calcium (D)</p> Signup and view all the answers

What is the normal range of extracellular calcium levels in the blood?

<p>8.5-10 mg/dl (B)</p> Signup and view all the answers

What is the effect of hypoalbuminemia on calcium levels in the blood?

<p>Decreased total calcium levels and increased free-ionized calcium (A)</p> Signup and view all the answers

What are the two possibilities for developing true hypocalcemia?

<p>Less calcium entering the blood and too much calcium leaving the blood (A)</p> Signup and view all the answers

What percentage of calcium is found in the bones of the human body?

<p>99% (B)</p> Signup and view all the answers

What is the primary function of ligand-gated channels in cells?

<p>To control the flow of calcium into cells (A)</p> Signup and view all the answers

What is the term for the process of programmed cell death?

<p>Apoptosis (D)</p> Signup and view all the answers

What is the primary function of ATP-dependent calcium pumps in cells?

<p>To regulate calcium levels in cells (B)</p> Signup and view all the answers

What is the range of normal calcium levels in the blood?

<p>8.5-10 mg/dL (D)</p> Signup and view all the answers

What is the term for the ionically linked calcium molecule that is electrically neutral and can cross cell membranes?

<p>Complexed calcium (A)</p> Signup and view all the answers

What is the role of the parathyroid hormone in regulating calcium levels?

<p>To increase calcium levels in the blood (C)</p> Signup and view all the answers

What is the term for the receptor that detects changes in extracellular calcium levels?

<p>Calcium-sensing receptor (A)</p> Signup and view all the answers

What is the primary function of voltage-gated channels in cells?

<p>To maintain the electrical membrane potential (B)</p> Signup and view all the answers

What is the term for the form of calcium that is bound to negatively charged proteins like albumin and globulin?

<p>Non-diffusible calcium (B)</p> Signup and view all the answers

What happens to the bound calcium in the blood when there's a low pH?

<p>It decreases due to the repulsion between positively charged albumin and calcium (B)</p> Signup and view all the answers

What is the effect of hyperalbuminemia on free ionized calcium concentrations in the blood?

<p>It has no effect on the concentration of free ionized calcium (A)</p> Signup and view all the answers

What is the most common cause of true hypercalcemia?

<p>Increased osteoclastic bone resorption (C)</p> Signup and view all the answers

What is the effect of high levels of ionized calcium on voltage-gated sodium channels?

<p>They are less likely to open up (A)</p> Signup and view all the answers

What is the consequence of hypercalciuria in the kidneys?

<p>It leads to a loss of excess fluid (C)</p> Signup and view all the answers

What is the typical diagnostic range for hypercalcemia in the blood?

<p>Above 10.5 mg/dL (A)</p> Signup and view all the answers

What is the effect of hypercalcemia on muscle contraction?

<p>It decreases muscle contraction speed (D)</p> Signup and view all the answers

What is the effect of hypercalcemia on the central nervous system?

<p>It causes confusion, hallucinations, and stupor (B)</p> Signup and view all the answers

What is the term for the condition where the concentration of bound calcium increases, but the concentration of free ionized calcium stays the same?

<p>Pseudohypercalcemia (C)</p> Signup and view all the answers

What is the effect of thiazide diuretics on calcium levels in the blood?

<p>They increase calcium reabsorption in the distal tubule (C)</p> Signup and view all the answers

What is the primary function of the 0.99% of extracellular calcium in the human body?

<p>To regulate muscle and nerve function (C)</p> Signup and view all the answers

What is the consequence of high levels of calcium in the interstitial space between cells?

<p>Increased apoptosis (D)</p> Signup and view all the answers

What is the primary mechanism by which cells regulate their intracellular calcium levels?

<p>By using ATP-dependent calcium pumps (A)</p> Signup and view all the answers

What is the function of the 0.01% of intracellular calcium in the human body?

<p>To facilitate cell signaling (A)</p> Signup and view all the answers

What is the primary difference between ligand-gated and voltage-gated channels in the cell membrane?

<p>Ligand-gated channels are primarily controlled by hormones, while voltage-gated channels are primarily controlled by electrical membrane potential (D)</p> Signup and view all the answers

What is the consequence of low levels of extracellular calcium on muscle contraction?

<p>Decreased muscle contraction (A)</p> Signup and view all the answers

What is the primary function of sodium-calcium exchangers in cells?

<p>To remove excess calcium from the cell (A)</p> Signup and view all the answers

What is the effect of a decrease in pH on the concentration of free-ionized calcium in the blood?

<p>It increases the concentration of free-ionized calcium (D)</p> Signup and view all the answers

What is the purpose of the calcium-sensing receptor in parathyroid cells?

<p>To detect changes in extracellular calcium levels (B)</p> Signup and view all the answers

What is the term for the condition in which total calcium levels appear normal, but free-ionized calcium levels are low?

<p>Pseudohypocalcemia (B)</p> Signup and view all the answers

What is the primary function of ATP-dependent calcium pumps in cells?

<p>To remove excess calcium from the cell (C)</p> Signup and view all the answers

What is the effect of an increase in albumin levels on the concentration of free-ionized calcium in the blood?

<p>It decreases the concentration of free-ionized calcium (D)</p> Signup and view all the answers

What is the term for the form of calcium that is involved in cellular processes like neuronal action potentials and muscle contraction?

<p>Free-ionized calcium (B)</p> Signup and view all the answers

What is the purpose of parathyroid hormone released by the parathyroid gland?

<p>To increase the concentration of free-ionized calcium in the blood (B)</p> Signup and view all the answers

What is the effect of a decrease in parathyroid hormone levels on the concentration of free-ionized calcium in the blood?

<p>It decreases the concentration of free-ionized calcium (B)</p> Signup and view all the answers

What is the term for the process by which the body regulates the concentration of extracellular calcium levels?

<p>Homeostasis (D)</p> Signup and view all the answers

What is the primary mechanism by which tissue injury leads to hypocalcemia?

<p>Intracellular phosphate release binds to ionized calcium (D)</p> Signup and view all the answers

Which of the following is a cause of hypocalcemia due to too much calcium leaving the blood?

<p>Kidney failure (C)</p> Signup and view all the answers

What is the effect of low ionized calcium levels on voltage-gated sodium channels?

<p>They become less stable and more likely to open (B)</p> Signup and view all the answers

What is the primary goal of treatment in hypocalcemia?

<p>To normalize calcium levels in the blood (B)</p> Signup and view all the answers

What is the effect of citrate and EDTA in blood transfusions on ionized calcium levels?

<p>They decrease ionized calcium levels (D)</p> Signup and view all the answers

What is the term for the facial muscle twitching that occurs when the facial nerve is lightly tapped?

<p>Chvostek's sign (A)</p> Signup and view all the answers

Which of the following is a cause of hypocalcemia due to low calcium entering the blood?

<p>Hypoparathyroidism (B)</p> Signup and view all the answers

What is the primary function of Na+-Ca2+ exchangers in cells?

<p>To pump excess calcium out of the cell (A)</p> Signup and view all the answers

What is the effect of low ionized calcium levels on electrically active neurons?

<p>They become more excitable (B)</p> Signup and view all the answers

What is the primary cause of hypocalcemia in the majority of cases?

<p>Low calcium entering the blood (B)</p> Signup and view all the answers

What is the effect of a decrease in blood pH on the binding of calcium to albumin?

<p>Decreased binding of calcium to albumin (D)</p> Signup and view all the answers

What is the primary function of ligand-gated channels in bone cells?

<p>To regulate the release of calcium from bones (D)</p> Signup and view all the answers

What is the term for the muscle spasm that occurs when the blood pressure cuff occludes the brachial artery?

<p>Trousseau's sign (D)</p> Signup and view all the answers

What is the consequence of high levels of calcium in the mitochondria?

<p>Increased cell death (B)</p> Signup and view all the answers

What is the function of the smooth endoplasmic reticulum in regulating calcium levels?

<p>To store calcium and release it selectively (B)</p> Signup and view all the answers

What is the effect of a decrease in parathyroid hormone on calcium levels in the blood?

<p>Decreased calcium levels (B)</p> Signup and view all the answers

What is the function of ATP-dependent calcium pumps in muscle cells?

<p>To pump excess calcium out of the cell (B)</p> Signup and view all the answers

What is the effect of an increase in extracellular calcium on voltage-gated calcium channels?

<p>Increased flow of calcium into the cell (B)</p> Signup and view all the answers

What is the function of the parathyroid gland in regulating calcium levels?

<p>To regulate all of the above (D)</p> Signup and view all the answers

What is the term for the calcium molecule that is ionically linked to oxalate?

<p>Complexed calcium (C)</p> Signup and view all the answers

What is the effect of a low pH on the binding of calcium to albumin?

<p>Calcium is released from albumin (D)</p> Signup and view all the answers

What is the primary cause of false hypercalcemia?

<p>High albumin levels (B)</p> Signup and view all the answers

What is the effect of high levels of ionized calcium on electrically active neurons?

<p>It makes it harder for neurons to reach depolarization (C)</p> Signup and view all the answers

What is the result of overstimulated osteoclasts without enough osteoblasts?

<p>Lytic bone lesions (C)</p> Signup and view all the answers

What is the primary mechanism by which the kidneys respond to high levels of calcium in the blood?

<p>Increased calcium excretion in the urine (A)</p> Signup and view all the answers

What is the effect of hyperalbuminemia on total calcium levels in the blood?

<p>It increases total calcium levels (C)</p> Signup and view all the answers

What is the primary cause of hypercalcemia in people with dehydration?

<p>High albumin levels (D)</p> Signup and view all the answers

What is the effect of high levels of ionized calcium on muscle contraction?

<p>It slows down muscle contraction (C)</p> Signup and view all the answers

What is the primary mechanism by which calcium affects cellular processes?

<p>It affects voltage-gated sodium channels (A)</p> Signup and view all the answers

What is the result of the combination of hypercalciuria and dehydration?

<p>Kidney stones (A)</p> Signup and view all the answers

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