Podcast
Questions and Answers
What is the primary cause of hyperthyroidism in most patients?
What is the primary cause of hyperthyroidism in most patients?
- Graves' disease (correct)
- Autoimmune destruction of thyroid tissue
- Dietary iodine deficiency
- Thyroid adenoma
How do thyroid-stimulating autoantibodies (TSAbs) affect TSH production?
How do thyroid-stimulating autoantibodies (TSAbs) affect TSH production?
- They stimulate excess TSH production.
- They degrade TSH within the blood.
- They inhibit TSH production leading to low levels in plasma. (correct)
- They have no effect on TSH production.
Which of the following symptoms is NOT typically associated with hyperthyroidism?
Which of the following symptoms is NOT typically associated with hyperthyroidism?
- Diarrhea
- Intolerance to heat
- Tachycardia
- Weight gain (correct)
What is the effect of thyroid adenoma on the rest of the thyroid gland?
What is the effect of thyroid adenoma on the rest of the thyroid gland?
What leads to the nervousness and extreme anxiety observed in hyperthyroid patients?
What leads to the nervousness and extreme anxiety observed in hyperthyroid patients?
Which symptom is specifically associated with Graves' disease but not typically with thyroid adenoma?
Which symptom is specifically associated with Graves' disease but not typically with thyroid adenoma?
What physiological process primarily contributes to heat intolerance in hyperthyroid patients?
What physiological process primarily contributes to heat intolerance in hyperthyroid patients?
Which of the following describes the lifespan of TSAbs compared to TSH?
Which of the following describes the lifespan of TSAbs compared to TSH?
What is the primary cause of exophthalmos in hyperthyroid patients?
What is the primary cause of exophthalmos in hyperthyroid patients?
What leads to blindness in patients with severe exophthalmos?
What leads to blindness in patients with severe exophthalmos?
Which of the following is NOT a characteristic symptom of myxedema?
Which of the following is NOT a characteristic symptom of myxedema?
What genetic condition is associated with myxedema in adults?
What genetic condition is associated with myxedema in adults?
What contributes to atherosclerosis in myxedema patients?
What contributes to atherosclerosis in myxedema patients?
Which substance accumulates in hard tissue associated with non-pitting edema in myxedema?
Which substance accumulates in hard tissue associated with non-pitting edema in myxedema?
Which hormone deficiency is NOT associated with the development of myxedema?
Which hormone deficiency is NOT associated with the development of myxedema?
What is the main factor causing the hard, non-pitting edema observed in myxedema?
What is the main factor causing the hard, non-pitting edema observed in myxedema?
Which symptom is NOT typically associated with hypothyroidism in adults?
Which symptom is NOT typically associated with hypothyroidism in adults?
Which of the following is NOT a characteristic feature of cretinism?
Which of the following is NOT a characteristic feature of cretinism?
What is the primary treatment for hypothyroidism?
What is the primary treatment for hypothyroidism?
What leads to the symptoms of cretinism if untreated?
What leads to the symptoms of cretinism if untreated?
Which of the following antithyroid substances works by inhibiting iodide trapping?
Which of the following antithyroid substances works by inhibiting iodide trapping?
Which sign is commonly seen in a newborn affected by thyroid deficiency?
Which sign is commonly seen in a newborn affected by thyroid deficiency?
Which feature is characteristic of goiter?
Which feature is characteristic of goiter?
Which symptom is least likely associated with hypothyroidism in adults?
Which symptom is least likely associated with hypothyroidism in adults?
Flashcards
Hypothyroidism
Hypothyroidism
A condition where the thyroid gland is underactive, leading to a deficiency of thyroid hormones.
Cretinism
Cretinism
Hypothyroidism in children, characterized by stunted growth and mental retardation if left untreated.
Goiter
Goiter
Enlargement of the thyroid gland, occurring in both hypothyroidism and hyperthyroidism.
Hyperthyroidism
Hyperthyroidism
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Antithyroid Substances
Antithyroid Substances
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Thyroidectomy
Thyroidectomy
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Hypertension
Hypertension
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Anemia
Anemia
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Graves' disease
Graves' disease
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Thyroid Stimulating Auto antibodies (TSAbs)
Thyroid Stimulating Auto antibodies (TSAbs)
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Thyroid adenoma
Thyroid adenoma
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Exophthalmos
Exophthalmos
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Polycythemia
Polycythemia
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Increased Basal Metabolic Rate (BMR) in hyperthyroidism
Increased Basal Metabolic Rate (BMR) in hyperthyroidism
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Tachycardia
Tachycardia
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Exophthalmos-induced optic nerve damage
Exophthalmos-induced optic nerve damage
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Corneal dryness from exophthalmos
Corneal dryness from exophthalmos
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Myxedema
Myxedema
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Hard, non-pitting edema in myxedema
Hard, non-pitting edema in myxedema
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Atherosclerosis in myxedema
Atherosclerosis in myxedema
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Hashimoto's thyroiditis
Hashimoto's thyroiditis
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Study Notes
Hyperthyroidism
- Hyperthyroidism is caused by Graves' disease or thyroid adenoma.
- In most cases of hyperthyroidism, the thyroid gland is two to three times larger than normal, with significant cell growth (hyperplasia). Each cell also secretes significantly more hormone.
- Graves' disease is an autoimmune disorder. B lymphocytes (plasma cells) produce antibodies (TSAbs/TSI) that mimic TSH. These antibodies bind to TSH receptors on thyroid follicular cells, activating cAMP signaling pathways. This results in excess thyroid hormone secretion. TSAbs affect the receptors for up to 12 hours, versus TSH's one hour effect. High antibody concentrations repress TSH production, resulting in very low or absent TSH levels in the blood.
Thyroid Adenoma
- A localized tumor in the thyroid tissue.
- It secretes large amounts of thyroid hormones.
- The active adenoma prevents normal thyroid tissue from producing its hormone.
Symptoms of Hyperthyroidism
- Intolerance to heat: Increased metabolic rate.
- Increased sweating: Due to vasodilation.
- Weight loss: Due to increased metabolic rate.
- Diarrhea: Increased motility of the gastrointestinal tract.
- Muscular weakness: Excess protein breakdown.
- Nervousness, fatigue, sleep disturbance: Excess stimulation of the nervous system.
- Tremors (mild): In the hands.
- Anxiety/worry: Psychoneurotic symptoms.
- Eye problems (exophthalmos): Protrusion of the eyeballs due to swelling of retro-orbital tissues and changes in extraocular muscles. Can lead to blindness.
- Tachycardia and atrial fibrillation: Rapid heartbeat.
- Systolic hypertension: High blood pressure (systolic).
- Cardiac failure: Potential life-threatening complication.
Hypothyroidism
- Decreased thyroid hormone secretion.
- Leads to myxedema (in adults) and cretinism (in children).
Myxedema
- Characterized by generalized edematous appearance (swelling).
- Occurs due to diseases of the thyroid gland, genetic disorders, iodine deficiency, or hormone deficiencies.
- Hashimoto's thyroiditis (common in women) is an autoimmune condition damaging the thyroid cells, leading to destruction and fibrosis.
- Symptoms:
- Swelling of the face.
- Bagginess under the eyes.
- Nonpitting edema.
- Atherosclerosis (hardening of arteries).
Cretinism
- Stunted growth in children caused by hypothyroidism.
- Possible causes include congenital absence of the thyroid gland, genetic disorder, or iodine deficiency.
Goiter
- Enlargement of the thyroid gland.
- Can occur in both hypothyroidism and hyperthyroidism.
Treatment
- Hyperthyroidism: Antithyroid substances to suppress thyroid hormone production, or surgery (thyroidectomy) for advanced cases.
- Hypothyroidism: Thyroid extract or thyroxine tablets.
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