Questions and Answers
What is Fredrickson's Classification scheme, how many different categories are there, and does this scheme address primary or secondary dyslipidemias?
Fredrickson Classification divides Primary Dyslipidemias into 6 categories labeled as 1, 2a, 2b, 3, 4, 5.
In type 1 Fredrickson classification, what lipoprotein particles are elevated and how does this patient's lipid panel compare to a healthy individual with regards to total cholesterol and triglycerides?
Type 1 Fredrickson is characterized by elevated Chylomicrons. Type 1 patients will have very high serum triglyceride levels but their total cholesterol should be normal.
Type 1 Fredrickson patients will have elevated Total Serum Cholesterol and elevated Triglycerides.
False
A patient with elevated triglycerides, nominal total serum cholesterol, and elevated chylomicrons falls into what category within Fredrickson Classification?
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Other than dyslipidemia, Fredrickson Type 1 patients have what other associated clinical disorders?
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Deficiency in Lipoprotein Lipase activity or in Apo-C2 are associated with what category on the Fredrickson Classification table?
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In type 2a Fredrickson classification, what lipoprotein particles are elevated and how does this patient's lipid panel compare to a healthy individual regarding total cholesterol and triglycerides?
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Type 2a Fredrickson patients will have elevated Total Serum Cholesterol and very high Triglycerides.
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A patient with normal triglycerides, very high total serum cholesterol, and elevated LDL falls into what category within Fredrickson Classification?
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Which Fredrickson Classes involve elevated Chylomicron particles in the blood?
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In terms of lipoprotein particles, how do Fredrickson's Type 2A, Type 2B, and Type 4 compare?
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A patient with very high serum cholesterol, elevated triglycerides, in the context of elevated LDL & VLDL falls within which of Fredrickson's Classifications?
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In type 2B Fredrickson classification, what lipoprotein particles are elevated and how does this patient's lipid panel compare to a healthy individual with regards to total cholesterol and triglycerides?
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What associated clinical disorder, other than dyslipidemia, is common to Fredrickson Type 2A, Type 2B, and Type 4 patients?
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What Fredrickson's classification is associated with Diabetes?
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What clinical disorder is associated with Type 5 dyslipidemia?
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How can you differentiate a Type 4 from a Type 5 dyslipidemia if both conditions have elevated total cholesterol and very high triglyceride levels?
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What are the two most common types of dyslipidemia using Fredrickson Classification?
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Familial Hypertriglyceridemia is a clinical disorder associated with which Fredrickson's class of dyslipidemia?
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Study Notes
Fredrickson Classification of Dyslipidemias
- Divides Primary Dyslipidemias into 6 categories: 1, 2a, 2b, 3, 4, 5.
- Indicates classification primarily for dyslipidemias, not addressing secondary forms.
Type 1 Dyslipidemia
- Characterized by elevated Chylomicrons.
- Patients exhibit very high serum triglycerides with normal total cholesterol levels.
- Associated clinical disorders include deficiencies in Lipoprotein Lipase or Apo-C2.
Type 2a Dyslipidemia
- Defined by elevated LDL particles.
- Patients show elevated total serum cholesterol and normal triglyceride levels.
- Differentiated from Type 1 by the specific rise in LDL while triglycerides remain normal.
Type 2b Dyslipidemia
- Features elevated LDL and VLDL particles.
- Patients present with very high total cholesterol and elevated triglyceride levels.
- Associated with Familial Combined Hyperlipidemia, common in Types 2A, 2B, and 4.
Type 4 Dyslipidemia
- Characterized by elevated VLDL particles.
- Associated with Diabetes, alongside Type 5 dyslipidemia.
- In lipid panels, presents with elevated total cholesterol and very high triglycerides mainly due to VLDL.
Type 5 Dyslipidemia
- Involves elevated VLDL and Chylomicrons.
- Also associated with Diabetes, showcasing similar lipid findings as Type 4 but distinguished by the presence of Chylomicrons.
Common Dyslipidemia Types
- Type 4 and Type 2B are the most prevalent types of dyslipidemia.
- Familial Hypertriglyceridemia is specifically linked to Type 4 dyslipidemia.
Distinguishing Dyslipidemia Types
- Type 4 can be differentiated from Type 5 by solely elevated VLDL in Type 4, whereas Type 5 has both elevated VLDL and Chylomicrons.
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Description
This quiz focuses on Fredrickson's Classification of Hyperlipidemia, which categorizes primary dyslipidemias into six distinct types. You'll explore the details of each type, including the specific lipoproteins involved and their impact on lipid panels. Test your understanding of this important classification scheme in the context of clinical implications for lipid management.
