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Questions and Answers
What is Fredrickson's Classification scheme, how many different categories are there, and does this scheme address primary or secondary dyslipidemias?
What is Fredrickson's Classification scheme, how many different categories are there, and does this scheme address primary or secondary dyslipidemias?
Fredrickson Classification divides Primary Dyslipidemias into 6 categories labeled as 1, 2a, 2b, 3, 4, 5.
In type 1 Fredrickson classification, what lipoprotein particles are elevated and how does this patient's lipid panel compare to a healthy individual with regards to total cholesterol and triglycerides?
In type 1 Fredrickson classification, what lipoprotein particles are elevated and how does this patient's lipid panel compare to a healthy individual with regards to total cholesterol and triglycerides?
Type 1 Fredrickson is characterized by elevated Chylomicrons. Type 1 patients will have very high serum triglyceride levels but their total cholesterol should be normal.
Type 1 Fredrickson patients will have elevated Total Serum Cholesterol and elevated Triglycerides.
Type 1 Fredrickson patients will have elevated Total Serum Cholesterol and elevated Triglycerides.
False (B)
A patient with elevated triglycerides, nominal total serum cholesterol, and elevated chylomicrons falls into what category within Fredrickson Classification?
A patient with elevated triglycerides, nominal total serum cholesterol, and elevated chylomicrons falls into what category within Fredrickson Classification?
Other than dyslipidemia, Fredrickson Type 1 patients have what other associated clinical disorders?
Other than dyslipidemia, Fredrickson Type 1 patients have what other associated clinical disorders?
Deficiency in Lipoprotein Lipase activity or in Apo-C2 are associated with what category on the Fredrickson Classification table?
Deficiency in Lipoprotein Lipase activity or in Apo-C2 are associated with what category on the Fredrickson Classification table?
In type 2a Fredrickson classification, what lipoprotein particles are elevated and how does this patient's lipid panel compare to a healthy individual regarding total cholesterol and triglycerides?
In type 2a Fredrickson classification, what lipoprotein particles are elevated and how does this patient's lipid panel compare to a healthy individual regarding total cholesterol and triglycerides?
Type 2a Fredrickson patients will have elevated Total Serum Cholesterol and very high Triglycerides.
Type 2a Fredrickson patients will have elevated Total Serum Cholesterol and very high Triglycerides.
A patient with normal triglycerides, very high total serum cholesterol, and elevated LDL falls into what category within Fredrickson Classification?
A patient with normal triglycerides, very high total serum cholesterol, and elevated LDL falls into what category within Fredrickson Classification?
Which Fredrickson Classes involve elevated Chylomicron particles in the blood?
Which Fredrickson Classes involve elevated Chylomicron particles in the blood?
In terms of lipoprotein particles, how do Fredrickson's Type 2A, Type 2B, and Type 4 compare?
In terms of lipoprotein particles, how do Fredrickson's Type 2A, Type 2B, and Type 4 compare?
A patient with very high serum cholesterol, elevated triglycerides, in the context of elevated LDL & VLDL falls within which of Fredrickson's Classifications?
A patient with very high serum cholesterol, elevated triglycerides, in the context of elevated LDL & VLDL falls within which of Fredrickson's Classifications?
In type 2B Fredrickson classification, what lipoprotein particles are elevated and how does this patient's lipid panel compare to a healthy individual with regards to total cholesterol and triglycerides?
In type 2B Fredrickson classification, what lipoprotein particles are elevated and how does this patient's lipid panel compare to a healthy individual with regards to total cholesterol and triglycerides?
What associated clinical disorder, other than dyslipidemia, is common to Fredrickson Type 2A, Type 2B, and Type 4 patients?
What associated clinical disorder, other than dyslipidemia, is common to Fredrickson Type 2A, Type 2B, and Type 4 patients?
What Fredrickson's classification is associated with Diabetes?
What Fredrickson's classification is associated with Diabetes?
What clinical disorder is associated with Type 5 dyslipidemia?
What clinical disorder is associated with Type 5 dyslipidemia?
How can you differentiate a Type 4 from a Type 5 dyslipidemia if both conditions have elevated total cholesterol and very high triglyceride levels?
How can you differentiate a Type 4 from a Type 5 dyslipidemia if both conditions have elevated total cholesterol and very high triglyceride levels?
What are the two most common types of dyslipidemia using Fredrickson Classification?
What are the two most common types of dyslipidemia using Fredrickson Classification?
Familial Hypertriglyceridemia is a clinical disorder associated with which Fredrickson's class of dyslipidemia?
Familial Hypertriglyceridemia is a clinical disorder associated with which Fredrickson's class of dyslipidemia?
Flashcards
Fredrickson's Classification
Fredrickson's Classification
A scheme dividing dyslipidemias into 6 categories.
Type 1 Dyslipidemia
Type 1 Dyslipidemia
Characterized by elevated Chylomicrons and high triglycerides, normal cholesterol.
Type 2a Dyslipidemia
Type 2a Dyslipidemia
Characterized by elevated LDL with high total cholesterol, normal triglycerides.
Type 2B Dyslipidemia
Type 2B Dyslipidemia
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Type 4 Dyslipidemia
Type 4 Dyslipidemia
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Type 5 Dyslipidemia
Type 5 Dyslipidemia
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Familial Combined Hyperlipidemia
Familial Combined Hyperlipidemia
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Chylomicron Elevation
Chylomicron Elevation
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LDL Levels
LDL Levels
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VLDL Levels
VLDL Levels
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Triglycerides Normal
Triglycerides Normal
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Diabetes and Dyslipidemia
Diabetes and Dyslipidemia
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High Total Cholesterol
High Total Cholesterol
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Type 4 vs Type 5 Differentiation
Type 4 vs Type 5 Differentiation
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Elevated Chylomicrons
Elevated Chylomicrons
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Familial Hypertriglyceridemia
Familial Hypertriglyceridemia
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Common Dyslipidemias
Common Dyslipidemias
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Total Serum Cholesterol
Total Serum Cholesterol
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High Serum Triglycerides
High Serum Triglycerides
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Study Notes
Fredrickson Classification of Dyslipidemias
- Divides Primary Dyslipidemias into 6 categories: 1, 2a, 2b, 3, 4, 5.
- Indicates classification primarily for dyslipidemias, not addressing secondary forms.
Type 1 Dyslipidemia
- Characterized by elevated Chylomicrons.
- Patients exhibit very high serum triglycerides with normal total cholesterol levels.
- Associated clinical disorders include deficiencies in Lipoprotein Lipase or Apo-C2.
Type 2a Dyslipidemia
- Defined by elevated LDL particles.
- Patients show elevated total serum cholesterol and normal triglyceride levels.
- Differentiated from Type 1 by the specific rise in LDL while triglycerides remain normal.
Type 2b Dyslipidemia
- Features elevated LDL and VLDL particles.
- Patients present with very high total cholesterol and elevated triglyceride levels.
- Associated with Familial Combined Hyperlipidemia, common in Types 2A, 2B, and 4.
Type 4 Dyslipidemia
- Characterized by elevated VLDL particles.
- Associated with Diabetes, alongside Type 5 dyslipidemia.
- In lipid panels, presents with elevated total cholesterol and very high triglycerides mainly due to VLDL.
Type 5 Dyslipidemia
- Involves elevated VLDL and Chylomicrons.
- Also associated with Diabetes, showcasing similar lipid findings as Type 4 but distinguished by the presence of Chylomicrons.
Common Dyslipidemia Types
- Type 4 and Type 2B are the most prevalent types of dyslipidemia.
- Familial Hypertriglyceridemia is specifically linked to Type 4 dyslipidemia.
Distinguishing Dyslipidemia Types
- Type 4 can be differentiated from Type 5 by solely elevated VLDL in Type 4, whereas Type 5 has both elevated VLDL and Chylomicrons.
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