Hypercapnia Risk in COPD Patients

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Questions and Answers

What is the classical explanation for worsening hypercapnia in patients with chronic CO2 retention exposed to high levels of inspired oxygen?

  • Stimulation of hypoxic drive to breathe
  • Suppression of hypoxic drive to breathe (correct)
  • Increased hypoxic drive to breathe
  • Enhanced hypercapnic drive

What is an important cause of hypoxemia in patients with COPD?

  • Increased alveolar ventilation
  • Ventilation–perfusion mismatch (correct)
  • Enhanced oxygen diffusion
  • Decreased perfusion mismatch

What happens to ventilation–perfusion (Va/Q) ratio when PaO2 is increased through supplemental oxygen administration?

  • It remains unchanged
  • It decreases due to abolished hypoxic pulmonary vasoconstriction (HPV) (correct)
  • It increases due to enhanced hypoxic pulmonary vasoconstriction (HPV)
  • It fluctuates randomly

What effect does increased perfusion have on better ventilated alveolar units in COPD patients receiving supplemental oxygen?

<p>They become oxygen enriched and have reduced CO2 elimination (C)</p> Signup and view all the answers

What happens to the gradient for CO2 when alveolar oxygen diffusion is enhanced through supplemental oxygen administration?

<p>It does not enhance due to reduced ventilation (A)</p> Signup and view all the answers

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