Hydrocortisone Sodium Succinate Overview

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Questions and Answers

What class does Hydrocortisone Sodium Succinate (Solu-Cortef) belong to?

  • Adrenal glucocorticoid (correct)
  • Mineralocorticoid
  • Estrogen
  • Androgen

What is the mechanism of action (MOA) of Hydrocortisone Sodium Succinate?

Anti-inflammatory; immunosuppressive with salt-retaining actions

What are the indications for Hydrocortisone Sodium Succinate?

Shock due to acute adrenocortical insufficiency, anaphylaxis, asthma, and COPD

What are the contraindications for Hydrocortisone Sodium Succinate?

<p>Systemic fungal infections, premature infants, known hypersensitivity</p> Signup and view all the answers

Common adverse effects (fx) of Hydrocortisone Sodium Succinate include ___ and fluid retention.

<p>headache</p> Signup and view all the answers

What are the drug interactions with Hydrocortisone Sodium Succinate?

<p>Incompatible with heparin and metaraminol</p> Signup and view all the answers

What is the dosage and administration (D&A) for adults using Hydrocortisone Sodium Succinate?

<p>4 mg/kg slow IV bolus</p> Signup and view all the answers

What is the dosage and administration (D&A) for pediatric patients using Hydrocortisone Sodium Succinate?

<p>2 mg/kg IV bolus, Max Dose: 100 mg</p> Signup and view all the answers

What is the duration of action for Hydrocortisone Sodium Succinate?

<p>Onset: 1 hr, Peak: variable, Duration: 8-12 hrs</p> Signup and view all the answers

What considerations should be taken when administering Hydrocortisone Sodium Succinate?

<p>Maybe used in status asthmaticus as a second-line drug</p> Signup and view all the answers

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Study Notes

Hydrocortisone Sodium Succinate (Solu-Cortef) Overview

  • Classified as an adrenal glucocorticoid, it serves various therapeutic roles in managing severe conditions.

Mechanism of Action (MOA)

  • Functions as an anti-inflammatory agent with immunosuppressive properties and promotes salt retention.

Indications for Use

  • Prescribed for shock stemming from acute adrenocortical insufficiency, anaphylaxis, asthma exacerbations, and chronic obstructive pulmonary disease (COPD).

Contraindications

  • Not suitable for patients with systemic fungal infections or known hypersensitivity;
  • Premature infants should avoid it due to the presence of benzyl alcohol, linked to "Fatal gasping syndrome" leading to CNS depression and metabolic acidosis.

Adverse Effects

  • Common side effects include headache, vertigo, hypertension, heart failure, fluid retention, nausea, and potential reactivation of pulmonary tuberculosis.

Drug Interactions

  • Known to be incompatible with anticoagulants like heparin and the vasopressor metaraminol.

Dosage and Administration for Adults

  • Administered as a slow intravenous (IV) bolus at a dosage of 4 mg/kg.

Dosage and Administration for Pediatric Patients

  • For children, the recommended IV bolus is 2 mg/kg, with a maximum dose of 100 mg.

Duration of Action

  • Onset of action occurs within 1 hour, with a variable peak effect and a duration of action lasting between 8 to 12 hours.

Additional Considerations

  • Can be utilized as a second-line treatment in cases of status asthmaticus, though caution is advised.

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