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Questions and Answers
What class does Hydrocortisone Sodium Succinate (Solu-Cortef) belong to?
What class does Hydrocortisone Sodium Succinate (Solu-Cortef) belong to?
What is the mechanism of action (MOA) of Hydrocortisone Sodium Succinate?
What is the mechanism of action (MOA) of Hydrocortisone Sodium Succinate?
Anti-inflammatory; immunosuppressive with salt-retaining actions
What are the indications for Hydrocortisone Sodium Succinate?
What are the indications for Hydrocortisone Sodium Succinate?
Shock due to acute adrenocortical insufficiency, anaphylaxis, asthma, and COPD
What are the contraindications for Hydrocortisone Sodium Succinate?
What are the contraindications for Hydrocortisone Sodium Succinate?
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Common adverse effects (fx) of Hydrocortisone Sodium Succinate include ___ and fluid retention.
Common adverse effects (fx) of Hydrocortisone Sodium Succinate include ___ and fluid retention.
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What are the drug interactions with Hydrocortisone Sodium Succinate?
What are the drug interactions with Hydrocortisone Sodium Succinate?
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What is the dosage and administration (D&A) for adults using Hydrocortisone Sodium Succinate?
What is the dosage and administration (D&A) for adults using Hydrocortisone Sodium Succinate?
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What is the dosage and administration (D&A) for pediatric patients using Hydrocortisone Sodium Succinate?
What is the dosage and administration (D&A) for pediatric patients using Hydrocortisone Sodium Succinate?
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What is the duration of action for Hydrocortisone Sodium Succinate?
What is the duration of action for Hydrocortisone Sodium Succinate?
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What considerations should be taken when administering Hydrocortisone Sodium Succinate?
What considerations should be taken when administering Hydrocortisone Sodium Succinate?
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Study Notes
Hydrocortisone Sodium Succinate (Solu-Cortef) Overview
- Classified as an adrenal glucocorticoid, it serves various therapeutic roles in managing severe conditions.
Mechanism of Action (MOA)
- Functions as an anti-inflammatory agent with immunosuppressive properties and promotes salt retention.
Indications for Use
- Prescribed for shock stemming from acute adrenocortical insufficiency, anaphylaxis, asthma exacerbations, and chronic obstructive pulmonary disease (COPD).
Contraindications
- Not suitable for patients with systemic fungal infections or known hypersensitivity;
- Premature infants should avoid it due to the presence of benzyl alcohol, linked to "Fatal gasping syndrome" leading to CNS depression and metabolic acidosis.
Adverse Effects
- Common side effects include headache, vertigo, hypertension, heart failure, fluid retention, nausea, and potential reactivation of pulmonary tuberculosis.
Drug Interactions
- Known to be incompatible with anticoagulants like heparin and the vasopressor metaraminol.
Dosage and Administration for Adults
- Administered as a slow intravenous (IV) bolus at a dosage of 4 mg/kg.
Dosage and Administration for Pediatric Patients
- For children, the recommended IV bolus is 2 mg/kg, with a maximum dose of 100 mg.
Duration of Action
- Onset of action occurs within 1 hour, with a variable peak effect and a duration of action lasting between 8 to 12 hours.
Additional Considerations
- Can be utilized as a second-line treatment in cases of status asthmaticus, though caution is advised.
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Description
This quiz provides an in-depth overview of Hydrocortisone Sodium Succinate (Solu-Cortef), covering its classification as an adrenal glucocorticoid and its therapeutic roles. It includes information on its mechanism of action, indications for use, contraindications, adverse effects, and drug interactions. Test your knowledge on this crucial medication used in severe conditions.
