Hydrocortisone Flashcards

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Questions and Answers

What is the drug class of Hydrocortisone?

  • Corticosteroid (correct)
  • Antihypertensive
  • Antibiotic
  • Analgesic

What is the mechanism of action of Hydrocortisone?

Binds cytosolic glucocorticoid receptors and prevents phospholipase from contacting arachidonic acid.

Which of the following are indications for Hydrocortisone? (Select all that apply)

  • Diabetes
  • Asthma attack (correct)
  • Kidney disease
  • Shock (correct)

Which of the following are contraindications for Hydrocortisone? (Select all that apply)

<p>Osteoporosis (B), Pregnancy (D)</p> Signup and view all the answers

What are some common side effects of Hydrocortisone?

<p>Insomnia, dizziness, headache, increased appetite, nervousness, sweating.</p> Signup and view all the answers

What serious side effects can occur with Hydrocortisone?

<p>Immunosuppression, adrenal suppression, behavior changes, diabetes, osteoporosis, Cushing's syndrome, growth impairment.</p> Signup and view all the answers

Which of the following can interact with Hydrocortisone? (Select all that apply)

<p>Warfarin (A), NSAIDs (C), Antihypertensives (D)</p> Signup and view all the answers

How is Hydrocortisone eliminated from the body?

<p>Metabolized by the liver and excreted in urine.</p> Signup and view all the answers

What is the usual dose of Hydrocortisone for shock or asthma?

<p>200 mg IV.</p> Signup and view all the answers

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Study Notes

Hydrocortisone Overview

  • Hydrocortisone belongs to the corticosteroid drug class, commonly used to treat various conditions due to its anti-inflammatory properties.

Mechanism of Action

  • Binds to cytosolic glucocorticoid receptors, inhibiting phospholipase activity.
  • Prevents the conversion of membrane phospholipids to arachidonic acid, thus reducing the production of prostaglandins and leukotrienes, which are key mediators of inflammation.

Indications for Use

  • Effective in managing asthma attacks and adrenocortical insufficiency.
  • Used in treating shock, hypersensitivity reactions, severe inflammatory bowel disease (IBD), hemorrhoids, rheumatic diseases, and various skin conditions.

Contraindications

  • Should not be used in patients with pregnancy, osteoporosis, kidney diseases, psychiatric disorders, or autoimmune diseases due to potential complications.

Side Effects

  • Common side effects include insomnia, dizziness, headaches, increased appetite, nervousness, and sweating.
  • Serious adverse effects involve immunosuppression, adrenal suppression, behavioral changes, diabetes development, osteoporosis, Cushing's syndrome, and growth impairment.

Drug Interactions

  • May interact with antihypertensives, NSAIDs, cardiac glycosides, theophylline, beta-2 agonists, potassium-losing diuretics, antidiabetics, and warfarin, necessitating careful monitoring.

Elimination

  • Hydrocortisone is metabolized by the liver and primarily excreted through urine, which is important for assessing dosing and potential buildup in the body.

Usual Dosage

  • For shock or asthma, a typical intravenous (IV) dose is 200 mg, which highlights its potency in acute settings.

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