Questions and Answers
What is the generic name of the drug HCTZ?
Hydrochlorothiazide
Which of the following are brand names for Hydrochlorothiazide? (Select all that apply)
What is the pharmacological class for Hydrochlorothiazide?
ACE inhibitor + diuretic
What are some common brands associated with Hydrochlorothiazide? (Select all that apply)
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What are the available dosage forms and strengths for Hydrochlorothiazide?
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What is the typical dosage for hypertension (HTN)?
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What is the dosage for treating edema with Hydrochlorothiazide?
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What is the off-label dosage for hypertension in heart failure?
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What is the management for Hydrochlorothiazide overdose?
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What does CrCl stand for in the context of dosing considerations for renal impairment?
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Study Notes
Hydrochlorothiazide Overview
- Generic name for the drug is Hydrochlorothiazide.
- Commonly prescribed under brand names: Microzide, HydroDiuril, Hydro, Esidrix, HCTZ, and Oretic.
- Classified as a thiazide diuretic, a common medication for fluid retention and hypertension.
Pharmacological Classification
- Combines the properties of an ACE inhibitor and diuretic.
Dosage Forms & Strengths
- Available in tablet/capsule forms with strengths: 12.5 mg, 25 mg, and 50 mg.
Indications & Dosage
- Hypertension (HTN): Recommended dosage ranges from 12.5 mg to 50 mg taken orally once daily.
- Edema: Dosage between 25 mg to 100 mg PO either once or twice daily, with a maximum limit of 200 mg/day.
- Hypertension in Heart Failure (Off-label): Suggests a starting dose of 25 mg PO once or twice daily, not to exceed 200 mg/day.
- Mild Fluid Retention in Heart Failure (Off-label): Same as for hypertension in heart failure.
Dosing Considerations
- In case of overdose:
- Use normal saline for volume replacement.
- Treat hypotension with dopamine or norepinephrine.
- If dysrhythmia arises from low potassium or magnesium, replace these electrolytes aggressively.
- If asymptomatic after 6 hours, discontinue treatment.
Dosing Modifications
- Adjustments may be necessary for patients with renal impairment, particularly when considering creatinine clearance (CrCl).
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Description
Test your knowledge of hydrochlorothiazide, a commonly used thiazide diuretic, with these flashcards. Each card features key definitions and associated brands, helping you to better understand this medication and its pharmacological class. Perfect for pharmacy students or healthcare professionals.
