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Questions and Answers
What volume of air is considered the anatomical dead space?
What volume of air is considered the anatomical dead space?
What is the tidal volume?
What is the tidal volume?
What is the volume of air that reaches the alveoli?
What is the volume of air that reaches the alveoli?
What is the formula used to calculate the percentage of fresh air reaching the alveoli?
What is the formula used to calculate the percentage of fresh air reaching the alveoli?
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What is the percentage of fresh air reaching the alveoli?
What is the percentage of fresh air reaching the alveoli?
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What is the main function of the respiratory system?
What is the main function of the respiratory system?
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Which of the following factors contributes to the decrease in Hb affinity for Oxygen in the tissues?
Which of the following factors contributes to the decrease in Hb affinity for Oxygen in the tissues?
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What is the name of the electrical signal that triggers a heart beat?
What is the name of the electrical signal that triggers a heart beat?
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Which of the following is NOT a component of the structure of the heart?
Which of the following is NOT a component of the structure of the heart?
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What is the difference between the atria and the ventricles of the heart?
What is the difference between the atria and the ventricles of the heart?
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What is the function of the pericardium?
What is the function of the pericardium?
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What are the components of the cardiac cycle?
What are the components of the cardiac cycle?
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Which of the following is NOT a function of the circulatory system?
Which of the following is NOT a function of the circulatory system?
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What is the function of the larynx?
What is the function of the larynx?
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Where does gas exchange occur in the circulatory system?
Where does gas exchange occur in the circulatory system?
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What is the role of the trachea?
What is the role of the trachea?
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Which vessel carries deoxygenated blood to the heart?
Which vessel carries deoxygenated blood to the heart?
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Which of the following statements is TRUE about the pulmonary artery?
Which of the following statements is TRUE about the pulmonary artery?
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What is the relationship between the pharynx and the larynx?
What is the relationship between the pharynx and the larynx?
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Which of the following is NOT a part of the respiratory system?
Which of the following is NOT a part of the respiratory system?
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Why is the pulmonary vein considered a vein even though it carries oxygenated blood?
Why is the pulmonary vein considered a vein even though it carries oxygenated blood?
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What is the primary role of the circulatory system in the respiratory process?
What is the primary role of the circulatory system in the respiratory process?
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What is the primary function of the nasal cavity in the respiratory process?
What is the primary function of the nasal cavity in the respiratory process?
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What is the key difference in excitation-contraction coupling between skeletal and cardiac muscle?
What is the key difference in excitation-contraction coupling between skeletal and cardiac muscle?
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What is the structure of myocardial cells?
What is the structure of myocardial cells?
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What is a key characteristic of cardiac muscle that distinguishes it from skeletal muscle?
What is a key characteristic of cardiac muscle that distinguishes it from skeletal muscle?
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What is the significance of the presence of gap junctions in myocardial cells?
What is the significance of the presence of gap junctions in myocardial cells?
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Which of these statements is TRUE regarding taurine?
Which of these statements is TRUE regarding taurine?
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What is the key role of ATP in the process of muscle contraction?
What is the key role of ATP in the process of muscle contraction?
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What is the function of the troponin complex in muscle contraction?
What is the function of the troponin complex in muscle contraction?
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What is the direct consequence of calcium ions binding to troponin in muscle contraction?
What is the direct consequence of calcium ions binding to troponin in muscle contraction?
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What is the role of the myosin head in the muscle contraction process?
What is the role of the myosin head in the muscle contraction process?
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How does the concentration of calcium ions in the muscle cell influence the contraction process?
How does the concentration of calcium ions in the muscle cell influence the contraction process?
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What is the key difference between skeletal muscle and cardiac muscle contraction, based on the provided information?
What is the key difference between skeletal muscle and cardiac muscle contraction, based on the provided information?
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What is the main function of the myosin filaments in muscle contraction?
What is the main function of the myosin filaments in muscle contraction?
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According to the provided information, what happens when the concentration of calcium ions in the muscle cell decreases?
According to the provided information, what happens when the concentration of calcium ions in the muscle cell decreases?
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What is the name of the protein that anchors thin filaments in muscle cells?
What is the name of the protein that anchors thin filaments in muscle cells?
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What is the name of the protein that is responsible for the contraction of muscles?
What is the name of the protein that is responsible for the contraction of muscles?
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What is the name of the section of the muscle fiber between two Z-discs?
What is the name of the section of the muscle fiber between two Z-discs?
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Which of the following is NOT a characteristic of a myofibril?
Which of the following is NOT a characteristic of a myofibril?
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How does the arrangement of thin and thick filaments contribute to the striated pattern of muscle fibers?
How does the arrangement of thin and thick filaments contribute to the striated pattern of muscle fibers?
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What is the name of the light band in the sarcomere?
What is the name of the light band in the sarcomere?
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What is the name of the narrow light band in the center of the A-band?
What is the name of the narrow light band in the center of the A-band?
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What is the role of troponin in muscle contraction?
What is the role of troponin in muscle contraction?
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What is the name of the protein molecule that is attached to actin and blocks myosin binding sites in a relaxed muscle?
What is the name of the protein molecule that is attached to actin and blocks myosin binding sites in a relaxed muscle?
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What is the role of the myosin head in muscle contraction?
What is the role of the myosin head in muscle contraction?
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Which of the following events occurs first during muscle contraction?
Which of the following events occurs first during muscle contraction?
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What is the role of ATP in muscle contraction?
What is the role of ATP in muscle contraction?
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What is the term for the sliding of thin and thick filaments past each other during muscle contraction?
What is the term for the sliding of thin and thick filaments past each other during muscle contraction?
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What is the name of the structure that surrounds individual muscle fibers?
What is the name of the structure that surrounds individual muscle fibers?
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Which of the following is TRUE about the H-zone during muscle contraction?
Which of the following is TRUE about the H-zone during muscle contraction?
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Which of the following is NOT a factor that affects the force of muscle contraction?
Which of the following is NOT a factor that affects the force of muscle contraction?
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Flashcards
Anatomical Dead Space
Anatomical Dead Space
The volume of the respiratory system that doesn't participate in gas exchange.
Tidal Volume
Tidal Volume
The amount of air inhaled or exhaled during normal breathing.
Fresh Air Reaching Alveoli
Fresh Air Reaching Alveoli
The portion of inhaled air that participates in gas exchange in the lungs.
Calculation of Fresh Air Percentage
Calculation of Fresh Air Percentage
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Gas Exchange
Gas Exchange
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Hb Affinity for Oxygen
Hb Affinity for Oxygen
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O2 Movement in Lungs
O2 Movement in Lungs
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CO2 Movement in Tissues
CO2 Movement in Tissues
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Circulatory System Distribution
Circulatory System Distribution
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Structure of the Respiratory System
Structure of the Respiratory System
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Mechanics of Breathing
Mechanics of Breathing
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Electrical Activity of the Heart
Electrical Activity of the Heart
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Cardiac Cycle
Cardiac Cycle
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Pharynx
Pharynx
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Larynx
Larynx
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Trachea
Trachea
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Bronchus
Bronchus
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Pulmonary artery
Pulmonary artery
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Pulmonary vein
Pulmonary vein
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Vena cava
Vena cava
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Right atrium
Right atrium
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Left atrium
Left atrium
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Capillary beds
Capillary beds
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SA Node
SA Node
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Myocardial Cells
Myocardial Cells
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Skeletal Muscle Contraction
Skeletal Muscle Contraction
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Cardiac Cell Ca2+ Release
Cardiac Cell Ca2+ Release
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Taurine in Diet
Taurine in Diet
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Myosin Head
Myosin Head
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ATP Hydrolysis
ATP Hydrolysis
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Troponin Complex
Troponin Complex
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Tropomyosin
Tropomyosin
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Calcium Ion (Ca2+)
Calcium Ion (Ca2+)
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Power Stroke
Power Stroke
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Cardiac Muscle vs Skeletal Muscle
Cardiac Muscle vs Skeletal Muscle
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Excitation-Contraction Coupling
Excitation-Contraction Coupling
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Myocardial cell relaxation
Myocardial cell relaxation
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Myofibrils
Myofibrils
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Striated pattern
Striated pattern
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Z-discs
Z-discs
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Sarcomere
Sarcomere
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Thin filaments
Thin filaments
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Thick filaments
Thick filaments
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Actin
Actin
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Myosin
Myosin
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I-bands
I-bands
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A-bands
A-bands
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H-zone
H-zone
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Contraction mechanism
Contraction mechanism
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Study Notes
Important Dates for BIOM*3200
- Practice test 1 (from last year) is now available.
- Ask your TA if you have any questions about the practice test.
- Tuesday, January 21: CV lecture 1
- Thursday, January 23: CV lecture 2
- Friday, January 24: Office hours
- Monday, January 27: Office hours
- Tuesday, January 28: CV lecture 3 – Distinguished Clinician Scientist
- Thursday, January 30: Test #1
Cardio-Respiratory: Version 12
- Distribution of blood (blood pie chart): 449
- Structure of the respiratory system: 525-527
- Physical properties of lungs to mechanics of breathing: 530-533
- Lung volumes and capacities: 535-536
- Oxygen toxicity, nitrogen narcosis, hyperbaric oxygen therapy, decompression sickness: 545-546
- Hemoglobin: 552
- Carbon dioxide transport to ventilation and acid-base balance: 558-560
- High altitude to the end of the chapter: 563-566
Cardio-Respiratory: Version 13
- Distribution of blood (blood pie chart): 455
- Structure of the respiratory system: 533-535
- Physical properties of lungs to pulmonary disorders: 538-544.
- Disorders caused by High Partial Pressures of Gases: 552-553
- Hemoglobin: 559
- Carbon dioxide transport to ventilation and acid-base balance 565-568
- High altitude to the end of the chapter: 571-573
Cardio-Respiratory: Version 14
- Distribution of blood (blood pie chart): 455
- Structure of the respiratory system: 533-535
- Physical properties of lungs to pulmonary disorders: 538-544
- Disorders caused by High Partial Pressures of Gases: 552-553
- Hemoglobin: 559
- Carbon dioxide transport to ventilation and acid-base balance: 565-568
- Respiratory adaptations to high altitude: 573
Cardio-Respiratory: Version 15
- Distribution of blood (blood pie chart): 455
- Structure of the respiratory system: 533-535
- Disorders caused by High Partial Pressures of Gases: 536-544
- Hemoglobin: 559
- Carbon dioxide transport to ventilation and acid-base balance: 565-568
- Respiratory adaptations to high altitude: 573
Cardio-Respiratory: Version 16
- Distribution of blood (blood pie chart): 454
- The respiratory system (section 16.1): 532-535
- Physical properties of lungs to pulmonary disorders: 537-543
- Disorders caused by High Partial Pressures of Gases: 551-552
- Hemoglobin: 558-559
- Carbon dioxide transport to acid-base balance: 564-566
- Acclimatization to high altitude: 570
Learning Objectives
- Distribution of blood at-rest in the circulatory system
- Structure of the respiratory system
- Physical aspects of ventilation
- Mechanics of breathing
- Hemoglobin and Oxygen transport
Distribution of Blood in the Circulatory System at Rest
- The venous system contains most of the blood.
- It acts as a reservoir storing blood that can be released to the circulatory system during exercise or other appropriate conditions.
Structure of Blood Vessels
- Arteries provide resistance to blood flow from the heart.
- Veins can expand as they accumulate blood.
- The average pressure in veins is only 2 mmHg compared to 100 mmHg average arterial pressure.
Veins
- Venous pressure is too low to return blood to the heart.
- Skeletal muscle groups help return lower limb blood to the heart via contractions, this is called the "skeletal muscle pump".
- Breathing, abdominal and thoracic contractions help also to return venous blood to the heart
Arteries
- The elastic recoil of large elastic arteries maintains blood flow during the diastolic phase when the heart is resting.
- Small arteries and arterioles are less elastic.
- Their size changes slightly.
Capillaries
- There are over 40 billion capillaries in the body, meaning every cell is very close to a capillary.
- Capillaries have walls composed of a single cell layer, making exchange of materials between blood and tissues easier.
- Vasoconstriction decreases blood flow, and vasodilation increases it.
More about Capillaries
- Blood pressure forces fluid out of the capillary at the arterial end.
- Osmotic pressure draws fluid back into the capillary at the venous end
Air Passageways
- The nasal cavity leads to the pharynx (throat) which leads to the larynx.
- The larynx is where air diverts to the lungs and food to the esophagus.
- The larynx also contains folds called vocal cords.
The Pharynx and the Larynx
- The nasal cavity leads to the pharynx, a muscular passage connecting the nasal cavity to the larynx.
- The larynx is the part of the throat where air travels to the lungs and food passes the esophagus.
- The larynx contains structures called the vocal cords.
The Respiratory System
- The respiratory system's components include the trachea, bronchi, and the lungs.
- The respiratory system facilitates gas exchange (intake of oxygen, release of carbon dioxide).
Physical Properties of the Lungs: Inspiration and Compliance
- Lungs must be compliant (stretchable) to expand during inhalation.
- Lung compliance is measured as the change in lung volume per unit change in transpulmonary pressure.
- Lung diseases can reduce compliance
Physical Properties of the Lungs: Expiration and Elasticity
- To exhale, the lungs must shrink when tension is released, which requires elasticity.
- Elasticity, due to elastin proteins, allows the lungs to return to their initial size after being stretched.
- Lungs are normally attached to the chest wall, resulting in elastic tension during respiration.
Lungs are Normally Attached to the Chest Wall
- Lungs are attached to the chest wall via pleural membranes, which consist of a layer attached to the lung surface and another attached the inner chest wall.
- They generate a mucous-rich, lubricating fluid to allow them to slide easily within the thoracic cavity.
The Pleural Membranes
- The pleural fluid holds the two pleural membranes together.
- The pleural fluid acts as a lubricant, making the lungs able to slide easily within the thoracic cavity.
Physical Properties of the Lungs: Surface Tension
- Surface tension is exerted by fluid in the alveoli (air sacs).
- The alveolar fluid contains surfactant, a mixture of phospholipids and surfactant proteins.
- This surfactant reduces surface tension, preventing the alveoli from collapsing.
Physical Properties of the Lungs: Respiratory Distress Syndrome
- Premature babies may be born with insufficient surfactant.
- This causes the alveoli to collapse, making it hard to breathe.
Physical Properties of the Lungs: Lung Volumes and Capacities
- Tidal volume (volume of air breathed in and out in a normal breath).
- Inspiratory reserve volume (the volume of air inspired from rest to maximal inspiration).
- Expiratory reserve volume (the volume of air that can be expired from rest to maximal exhalation).
- Residual volume (the volume of air remaining in the lungs after the expiratory reserve volume is expelled).
Anatomical Dead Space
- Nose, mouth, larynx, trachea, bronchi, and bronchioles are areas where no gas exchange occurs.
- Anatomical dead space is approximately 150 ml.
Critical Thinking Questions
- Zombies (Walking Dead) & Vampires (Twilight): How does the percentage of fresh air reaching the alveoli change under fictional conditions of inspiration?
The Role of Hemoglobin
- Hemoglobin is an iron-containing protein in red blood cells.
- It binds to oxygen (O2), acting as a transport protein from the lungs to body tissues.
- Hemoglobin is very effective at carrying and releasing oxygen due to its chemical properties.
Carbon Dioxide/Oxygen Transport in Blood
- CO2 diffuses from the blood to the alveoli in the lungs, and from body tissues to the blood.
- CO2 levels are low in the blood of the lungs, which will result in less acidity.
- CO2 levels are high in the blood of body tissues, which will result in higher acidity.
- Hemoglobin also binds to CO2.
- Carbonic anhydrase is an enzyme that catalyzes the conversion of CO2 to bicarbonate (HCO3-) in red blood cells.
O₂ Uptake in the Lungs
- O₂ dissolves into the fluid lining the alveoli
- Moves from the alveoli to blood capillaries
- Combines with hemoglobin to form oxyhemoglobin.
- Oxyhemoglobin formation occurs in the lungs because blood CO₂ levels are low.
O₂ Release in the Tissues
- Oxygen (O2) is released from oxyhemoglobin and diffuses into body tissues.
- Dissociation occurs because plasma CO2 levels are high and pH goes down in body tissue, this is also referred to as becoming more acidic.
CO₂ Transport
- CO₂ is transported in the blood mostly as bicarbonate (HCO3−) .
- A small amount is carried chemically attached to hemoglobin.
Electrical Activity of the Heart
- Sinoatrial node (SA node) is the heart's pacemaker.
- Atrioventricular node (AV node) temporarily delays the electrical signal from the atria to ventricles.
- Purkinje fibers spread electrical signal throughout the ventricles.
The Electrocardiogram (ECG)
- The signals are recorded from the body by electrodes, and form the waveform of a complex, compound action potential.
Coronary Artery Disease
- Plaque buildup in the coronary arteries reduces blood flow to the heart.
- This can cause chest pain or angina.
Myocardial Infarction
- The complete blockage of blood flow can result in a myocardial infarction, or heart attack.
- Interruption to blood flow results in the death of heart muscle cells (myocardial cells).
ECG & Heart Disease
- An electrocardiogram or ECG, is a test to measure the electrical activity of the heart.
- Irregularities in the waveforms (e.g., ST-segment depression, prolonged PR interval, or QRS complex) can suggest underlying cardiac problems.
Tachycardia (Abnormal Heartbeat)
- Rapid heart rate, >100 bpm.
- Symptoms can include palpitations, shortness of breath, dizziness, and chest pain.
Bradycardia (Abnormal Heartbeat)
- Slow heart rate, < 60 bpm.
- Symptoms can include lightheadedness, fatigue, and fainting
Cardiac Muscle
- Cardiac muscle cells are short, branched, and interconnected.
- These cells contract in a coordinated way due to unique electrical synapses (gap junctions)
- The cells are striated, but contractions are involuntary.
Excitation-Contraction Coupling in Cardiac Muscle
- Voltage-gated calcium channels open and allows calcium to diffuse to the cytoplasm
- The diffusion of Ca2+ activates the Ca2+ release channels in the sarcoplasmic reticulum (SR); in this way, calcium (Ca2+) in the sarcoplasmic reticulum stimulates contraction.
- Ca2+-ATPase pumps calcium back into the SR to allow the cardiac muscle to relax.
Microanatomy of Muscle
- Muscle fibres are arranged into thick (myosin) and thin (actin) filaments.
- Z-discs act as anchors for thin filaments in the I-band.
- The A-band is comprised of thick filaments and portions of thin filaments.
- The H-zone is the centre of the A-band.
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Description
Test your knowledge on the human respiratory and circulatory systems with this quiz. Questions cover topics such as anatomical dead space, tidal volume, heart structure, and gas exchange. Perfect for students studying biology or health sciences.