Podcast
Questions and Answers
Which characteristic primarily differentiates a unipolar neuron from a bipolar neuron?
Which characteristic primarily differentiates a unipolar neuron from a bipolar neuron?
- The presence of multiple dendrites extending from the cell body.
- The number of processes extending from the cell body. (correct)
- The size of the axon hillock.
- The type of neurotransmitter released at the synapse.
In the central nervous system (CNS), which glial cell is responsible for myelinating multiple axons, increasing the speed of nerve impulse transmission?
In the central nervous system (CNS), which glial cell is responsible for myelinating multiple axons, increasing the speed of nerve impulse transmission?
- Oligodendrocytes (correct)
- Microglia
- Ependymal cells
- Astrocytes
Which glial cell type is primarily involved in regulating the ionic environment and providing structural support within the central nervous system (CNS)?
Which glial cell type is primarily involved in regulating the ionic environment and providing structural support within the central nervous system (CNS)?
- Satellite cells
- Microglia
- Ependymal cells
- Astrocytes (correct)
Which of the following is a key function of ependymal cells in the central nervous system?
Which of the following is a key function of ependymal cells in the central nervous system?
Microglia are specialized macrophages that play a crucial role in the central nervous system (CNS). What is their primary function?
Microglia are specialized macrophages that play a crucial role in the central nervous system (CNS). What is their primary function?
Which meningeal layer is characterized as a thick, dense irregular connective tissue and is continuous with the periosteum of the skull?
Which meningeal layer is characterized as a thick, dense irregular connective tissue and is continuous with the periosteum of the skull?
The subarachnoid space is crucial for protecting the central nervous system. What primary fluid does this space contain?
The subarachnoid space is crucial for protecting the central nervous system. What primary fluid does this space contain?
How does the arrangement of gray and white matter differ between the cerebrum and the spinal cord?
How does the arrangement of gray and white matter differ between the cerebrum and the spinal cord?
Which layer of the cerebral cortex is characterized by a high density of small pyramidal cells and is located just beneath the molecular layer?
Which layer of the cerebral cortex is characterized by a high density of small pyramidal cells and is located just beneath the molecular layer?
The Purkinje cells are a distinctive feature of the cerebellar cortex. In which layer of the cerebellar cortex are these cells primarily located?
The Purkinje cells are a distinctive feature of the cerebellar cortex. In which layer of the cerebellar cortex are these cells primarily located?
What is the primary function of the dorsal horns of the spinal cord's gray matter?
What is the primary function of the dorsal horns of the spinal cord's gray matter?
Which glial cell type is found primarily in the peripheral nervous system (PNS) and is responsible for myelinating axons?
Which glial cell type is found primarily in the peripheral nervous system (PNS) and is responsible for myelinating axons?
Satellite cells play a supportive role for neurons in the peripheral nervous system (PNS). What is their main function?
Satellite cells play a supportive role for neurons in the peripheral nervous system (PNS). What is their main function?
What is the role of the epineurium in the context of peripheral nerve structure?
What is the role of the epineurium in the context of peripheral nerve structure?
Along myelinated nerve fibers, what are the circular constrictions where the axon is not covered by myelin sheath called?
Along myelinated nerve fibers, what are the circular constrictions where the axon is not covered by myelin sheath called?
Which of the following best describes Nissl substance's primary function?
Which of the following best describes Nissl substance's primary function?
What is the primary structural and functional difference between myelinated and unmyelinated nerve fibers?
What is the primary structural and functional difference between myelinated and unmyelinated nerve fibers?
Within the spinal cord, what distinguishes the ventral horns from the dorsal horns?
Within the spinal cord, what distinguishes the ventral horns from the dorsal horns?
Which of the following describes the primary distinction between protoplasmic and fibrous astrocytes?
Which of the following describes the primary distinction between protoplasmic and fibrous astrocytes?
What is the main difference between a nerve and a tract within the nervous system?
What is the main difference between a nerve and a tract within the nervous system?
Which of the following is the key difference between a nucleus and a ganglion in the nervous system?
Which of the following is the key difference between a nucleus and a ganglion in the nervous system?
What primary feature distinguishes a spinal ganglion from an autonomic ganglion?
What primary feature distinguishes a spinal ganglion from an autonomic ganglion?
What is the role of voltage-regulated calcium ($Ca^{2+}$) channels in synaptic transmission?
What is the role of voltage-regulated calcium ($Ca^{2+}$) channels in synaptic transmission?
How do astrocytes contribute to the function of the blood-brain barrier?
How do astrocytes contribute to the function of the blood-brain barrier?
What critical event is directly mediated by the binding of acetylcholine (ACh) to receptors on the postsynaptic neuron?
What critical event is directly mediated by the binding of acetylcholine (ACh) to receptors on the postsynaptic neuron?
What is the functional significance of the arrangement of the cerebral cortex into distinct layers?
What is the functional significance of the arrangement of the cerebral cortex into distinct layers?
How does the presence of myelin sheaths affect the conduction velocity of nerve fibers?
How does the presence of myelin sheaths affect the conduction velocity of nerve fibers?
What is the primary difference in function between the white matter and the gray matter of the central nervous system?
What is the primary difference in function between the white matter and the gray matter of the central nervous system?
What mechanism accounts for the increased speed of impulse transmission in myelinated nerve fibers compared to unmyelinated nerve fibers?
What mechanism accounts for the increased speed of impulse transmission in myelinated nerve fibers compared to unmyelinated nerve fibers?
Which of the following is NOT a primary function of astrocytes in the CNS?
Which of the following is NOT a primary function of astrocytes in the CNS?
Compared to myelinated nerve fibers, unmyelinated nerve fibers typically exhibit which characteristic?
Compared to myelinated nerve fibers, unmyelinated nerve fibers typically exhibit which characteristic?
Which structure is responsible for the production and circulation of cerebrospinal fluid, lining the ventricles of the brain and central canal of the spinal cord?
Which structure is responsible for the production and circulation of cerebrospinal fluid, lining the ventricles of the brain and central canal of the spinal cord?
Compared to the gray matter of the cerebrum, what cellular feature is predominantly found in the white matter?
Compared to the gray matter of the cerebrum, what cellular feature is predominantly found in the white matter?
In regards to conduction velocity, how are unmyelinated nerve fibers characterized compared to myelinated nerve fibers?
In regards to conduction velocity, how are unmyelinated nerve fibers characterized compared to myelinated nerve fibers?
Which glial cell type is primarily responsible for insulating PNS axons?
Which glial cell type is primarily responsible for insulating PNS axons?
Nerve fibers that prevent the loss of nerve impulse are enclosed by what?
Nerve fibers that prevent the loss of nerve impulse are enclosed by what?
Where are you most likely to find Satellite Cells??
Where are you most likely to find Satellite Cells??
Which division of labor does dura mater perform in CNS?
Which division of labor does dura mater perform in CNS?
How do the structural components and arrangement of gray and white matter in the brain and spinal cord correlate with their respective functions?
How do the structural components and arrangement of gray and white matter in the brain and spinal cord correlate with their respective functions?
How does the unique structure of Purkinje neurons in the cerebellar cortex contribute to cerebellar function?
How does the unique structure of Purkinje neurons in the cerebellar cortex contribute to cerebellar function?
How do the morphological characteristics of neurons, such as the presence of dendritic spines, influence their function in neural circuits?
How do the morphological characteristics of neurons, such as the presence of dendritic spines, influence their function in neural circuits?
Which histological feature would best help you distinguish between a section of the cerebral cortex and a section of the cerebellar cortex?
Which histological feature would best help you distinguish between a section of the cerebral cortex and a section of the cerebellar cortex?
In a synapse, how do processes at the presynaptic terminal ensure unidirectional signal transmission and prevent signal reversal?
In a synapse, how do processes at the presynaptic terminal ensure unidirectional signal transmission and prevent signal reversal?
How does myelination affect the function of nerve fibers, and what cellular mechanisms underpin this effect?
How does myelination affect the function of nerve fibers, and what cellular mechanisms underpin this effect?
How can the presence or absence of myelin sheaths around axons be used to differentiate between white matter and gray matter in the central nervous system?
How can the presence or absence of myelin sheaths around axons be used to differentiate between white matter and gray matter in the central nervous system?
Considering the cellular composition of the cerebral cortex, how do the structural differences between its layers enable specialized functions?
Considering the cellular composition of the cerebral cortex, how do the structural differences between its layers enable specialized functions?
How do astrocytes facilitate neuronal function within the CNS, particularly concerning neurotransmitter activity and the blood-brain barrier?
How do astrocytes facilitate neuronal function within the CNS, particularly concerning neurotransmitter activity and the blood-brain barrier?
How does the arrangement of meningeal layers around the central nervous system enhance protection against mechanical injury and infection?
How does the arrangement of meningeal layers around the central nervous system enhance protection against mechanical injury and infection?
What distinguishes protoplasmic astrocytes from fibrous astrocytes in terms of their location, structure, and interaction with neurons?
What distinguishes protoplasmic astrocytes from fibrous astrocytes in terms of their location, structure, and interaction with neurons?
How does the structural organization of a peripheral nerve (epineurium, perineurium, endoneurium) contribute to its ability to withstand mechanical stress and facilitate nerve regeneration?
How does the structural organization of a peripheral nerve (epineurium, perineurium, endoneurium) contribute to its ability to withstand mechanical stress and facilitate nerve regeneration?
What are the key differences between myelinated and unmyelinated nerve fibers, and how do these differences impact nerve impulse conduction?
What are the key differences between myelinated and unmyelinated nerve fibers, and how do these differences impact nerve impulse conduction?
How does the differing structure of spinal and autonomic ganglia relate to their specific functions in sensory and autonomic control?
How does the differing structure of spinal and autonomic ganglia relate to their specific functions in sensory and autonomic control?
What mechanisms ensure the unidirectional flow of information at a synapse, preventing a postsynaptic neuron from activating the presynaptic neuron?
What mechanisms ensure the unidirectional flow of information at a synapse, preventing a postsynaptic neuron from activating the presynaptic neuron?
How are neuronal cell bodies and fiber tracts organized into gray and white matter in the spinal cord, and how does this arrangement relate to the spinal cord's functions?
How are neuronal cell bodies and fiber tracts organized into gray and white matter in the spinal cord, and how does this arrangement relate to the spinal cord's functions?
How do the structural features of the epineurium, perineurium, and endoneurium in peripheral nerves support nerve function and regeneration?
How do the structural features of the epineurium, perineurium, and endoneurium in peripheral nerves support nerve function and regeneration?
How do the distinct structural features of sensory neurons in dorsal root ganglia support their primary function of transmitting sensory information?
How do the distinct structural features of sensory neurons in dorsal root ganglia support their primary function of transmitting sensory information?
Given the functions of the central nervous system, what common features would you expect to observe across different regions of the brain?
Given the functions of the central nervous system, what common features would you expect to observe across different regions of the brain?
How does the structure of the cerebral cortex, with its layered arrangement of cells, contribute to its function?
How does the structure of the cerebral cortex, with its layered arrangement of cells, contribute to its function?
How does the structural arrangement of white and gray matter in the spinal cord contribute to its functions of transmitting signals between the brain and the body?
How does the structural arrangement of white and gray matter in the spinal cord contribute to its functions of transmitting signals between the brain and the body?
How does the presence of specialized glial cells like oligodendrocytes in white matter enhance the efficiency of neural signal transmission?
How does the presence of specialized glial cells like oligodendrocytes in white matter enhance the efficiency of neural signal transmission?
How does the structure and arrangement of the meninges contribute to the protection of the brain and spinal cord?
How does the structure and arrangement of the meninges contribute to the protection of the brain and spinal cord?
What is the functional correlation between the extensive branching of Purkinje cell dendrites and their role in cerebellar motor control?
What is the functional correlation between the extensive branching of Purkinje cell dendrites and their role in cerebellar motor control?
How do structural differences between myelinated and unmyelinated nerve fibers correlate with their function in signal transmission?
How do structural differences between myelinated and unmyelinated nerve fibers correlate with their function in signal transmission?
Flashcards
Multipolar Neuron
Multipolar Neuron
A cell with a single axon and multiple dendrites.
Astrocytes
Astrocytes
A type of CNS neuroglia, forms part of the blood-brain barrier.
Oligodendrocytes
Oligodendrocytes
A CNS neuroglia, It myelinates CNS axons.
Ependymal Cells
Ependymal Cells
Signup and view all the flashcards
Microglia
Microglia
Signup and view all the flashcards
Dura Mater
Dura Mater
Signup and view all the flashcards
Arachnoid Mater
Arachnoid Mater
Signup and view all the flashcards
Pia Mater
Pia Mater
Signup and view all the flashcards
White Matter
White Matter
Signup and view all the flashcards
Gray Matter
Gray Matter
Signup and view all the flashcards
Schwann Cells
Schwann Cells
Signup and view all the flashcards
Satellite Cells
Satellite Cells
Signup and view all the flashcards
Epineurium
Epineurium
Signup and view all the flashcards
Perineurium
Perineurium
Signup and view all the flashcards
Endoneurium
Endoneurium
Signup and view all the flashcards
Myelinated Nerve Fibers
Myelinated Nerve Fibers
Signup and view all the flashcards
Unmyelinated Nerve Fibers
Unmyelinated Nerve Fibers
Signup and view all the flashcards
Study Notes
- Human Histology Laboratory is MT120225
- The unit of study is unit 4 : Nervous Tissue
- School of Health Sciences, Dept of Medical Technology, UST General Santos are covering this in the second semester of A.Y. 2024-2025
Learning Outcomes
- Differentiate types of neurons based on struture.
- Identify the neuroglial cells in the CNS and PNS.
- Distinguish between the main regions of the brain and spinal cord, based on location and structural components.
- Identify the histologic layers of the cerebellum.
- Differentiate between myelinated and unmyelinated nerve fibers microscopically.
Overview of Nervous Tissue
- The topic outline includes:
- An overview of the nervous tissue
- Central and peripheral nervous systems
- Laboratory activities and review
Morphology of a Typical Neuron
- Components of a typical neuron include dendrites, a multipolar neuron, Nissl substance, an axon hillock and axon, and axons.
- Arteriole, neuroglia, nucleus and nucleolus can be present in multipolar neurons
- Gray matter of the anterior horn and white matter are other features
Neuron Cell Body
- Anterior horn of the human spinal cord can be stained with toluidine blue to show the cell body.
- The cell body contains neuroglial nuclei, a nucleolus, a nucleus, and Nissl bodies.
Dendrites
- Silver impregnated Purkinje neuron of the cerebellum.
Axon
- Axons, axon hillocks, glia, and dendrites are neuron components.
Cells of the Nervous Tissue: Neurons
- Structural classes of neurons include multipolar, bipolar, unipolar, and anaxonic neurons.
- Pseudounipolar neurons, containing satellite cells and cell bodies, exist in dorsal root ganglia.
- Bipolar neurons have axon hillocks, a soma, dendrites, and neuroglia.
- Multipolar neurons in the spinal cord have axons, axon hillocks, glia, soma, and dendrites.
- Neurons form synapses to communicate.
- The synapse includes the axon of a presynaptic neuron, calcium ions, a synaptic cleft, a postsynaptic membrane, and a postsynaptic neuron with sodium ions.
Central Nervous System
- The central nervous system can be broken down into cells of the nervous tissue called glial cells.
- Types of central neuroglia include astrocytes, oligodendrocytes, microglia, and ependymal cells
- Astrocytes form part of the blood-brain barrier, regulate interstitial fluid compisition, provides support to the CNS, assists with neuronal development, and replicates to occupy space of dying neurons
- Oligodendrocytes myelinates and insulates CNS axons and allows for faster action potential propagation along axons in the CNS
- Microglial cells are phagocytic cells that move through the CNS and protect it by engulfing potential hramful substances
- Ependymal cells line the ventricles of the brain and the central canal of the spinal cord
Astrocytes
- Types of Astrocytes, central neuroglia:
- Protoplasmic
- Fibrous
- Astrocytes are visible via Immunohistochemical staining in brain white matter using anti-GFAP antibodies
Other Central Neuroglia
- Oligodendrocytes
- Microglia
- Ependymal cells
- Line the trachea
Connective Tissue of the CNS
- There are 3 meningeal layers:
- Dura Mater, the outermost layer, is thick and continuous with the skull's periosteum.
- Arachnoid Mater, the middle layer, has a connective tissue sheet and trabeculae connecting to the pia mater.
- Pia Mater, the innermost layer, consists of flattened mesenchymal-derived cells.
Structures of the Central Nervous System
- Meninges include the dura mater, arachnoid mater, and pia mater.
- White matter consists mostly of myelinated nerve fibers, some unmyelinated fibers, and glial cells.
- Gray matter consists mostly of neuronal cell bodies, unmyelinated fibers, and neuroglial cells.
Cerebrum
- The cerebrum contains pia mater, gray matter, and white matter
- There are 6 layers to the cerebral cortex :
- Molecular
- External Granular
- External Pyramidal
- Internal Granular
- Ganglionic (internal pyramidal)
- Multiform (polymorphic)
Cerebellum
- Cerebellar cortex contains cell layers which are
- Molecular
- Granule
Spinal cord
- The spinal cord is part of the Central Nervous System and consists of
- Gray Matter, (H shaped)
- Consists of 2 dorsal horns with with interneurons that receive sensory fibers
- Contains 2 ventral horns, with multipolar motor neurons
- Gray Matter, (H shaped)
- White Matter
- Which is located on the periphery
- Consists of ascending and descending mostly myelinated fibers
- Which is located on the periphery
Peripheral Nervous System (PNS)
- Components:
- Nerve
- Ganglia
- Nerve Endings
Glial cells
- Types of Central Neuroglia
- Astryocytes
- Oligodendrocytes
- Microglia
- Ependymal cells
- Schwann and satellite cells are also glial cells
- Functions of Satellite Cells
- Electrically insulates the PNS cell bodies
- Regulates the nutrient and waste exchange for cell bodies in the ganglia
Peripheral Neuroglia
- Schwann cells.
- Myelinated nerve fibers show Schwann cells around axons and myelin sheaths.
- Satellite cells surround neurons of ganglia in the PNS.
Connective Tissue of the PNS:
Includes epineurium which is the external coat, perineurium which surrounds bundles of nerve, and endoneurium which surrounds individual nerve fibers
Peripheral Nerve
- Includes blood vessels, epineurium, and bundled nerve fibers.
Ganglion
- Consists of Nerve Fibers (NF), blood Vessels (BV), cell bodies (CB), Neuron (N) or Nucleus (NL)
Structures of the Peripheral Nervous System -Myelinated Nerve Fibers
- The fibers are enclosed by a myelin sheath, to prevent loss of nerve impulse
- Contains circular constrictions (nodes of ranvier)
- There are also internodal or schwann segments
Unmyelinated Nerve Fibers
- Naked axons
- No multiple wrapping
- Smaller diameter axons
- Still contain schwann cells
- No Nodes of ranvier
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.