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Questions and Answers
Which component of the lens is responsible for producing new lens fibers?
Which component of the lens is responsible for producing new lens fibers?
What is the primary component of the vitreous body?
What is the primary component of the vitreous body?
Which layer of the retina contains the photoreceptor cells?
Which layer of the retina contains the photoreceptor cells?
What are the primary functions of the lens fibers?
What are the primary functions of the lens fibers?
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What type of cells are classified as conducting neurons in the retina?
What type of cells are classified as conducting neurons in the retina?
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What structure serves as the suspensory ligament for the lens?
What structure serves as the suspensory ligament for the lens?
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Which cells are primarily found in the vitreous body?
Which cells are primarily found in the vitreous body?
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Which region of the neural retina is nonphotosensitive?
Which region of the neural retina is nonphotosensitive?
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What layers contain the cell bodies of retinal rods and cones?
What layers contain the cell bodies of retinal rods and cones?
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What is the main function of rods in the retina?
What is the main function of rods in the retina?
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Which layer of the retina is made up of the processes of bipolar and horizontal cells?
Which layer of the retina is made up of the processes of bipolar and horizontal cells?
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How many layers does the retina have, according to the organized structure described?
How many layers does the retina have, according to the organized structure described?
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What type of light do cone photoreceptors primarily detect?
What type of light do cone photoreceptors primarily detect?
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What is the primary visual pigment absorption peak for rods?
What is the primary visual pigment absorption peak for rods?
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Which type of retinal cell layer comprises the cell bodies of ganglion cells?
Which type of retinal cell layer comprises the cell bodies of ganglion cells?
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What structure forms the apical boundary of Müller’s cells in the retina?
What structure forms the apical boundary of Müller’s cells in the retina?
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What is one of the primary functions of the ciliary processes?
What is one of the primary functions of the ciliary processes?
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How does aqueous humor flow after being secreted into the posterior chamber?
How does aqueous humor flow after being secreted into the posterior chamber?
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What structure is located centrally within the iris?
What structure is located centrally within the iris?
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Which layer of the iris is heavily pigmented to prevent light from entering the eye?
Which layer of the iris is heavily pigmented to prevent light from entering the eye?
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What primarily determines the color of a person's eyes?
What primarily determines the color of a person's eyes?
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What is the role of fibroblasts and melanocytes in the anterior iridial border?
What is the role of fibroblasts and melanocytes in the anterior iridial border?
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What is the function of the Na+/K+-ATPase in non-pigmented cells of the ciliary processes?
What is the function of the Na+/K+-ATPase in non-pigmented cells of the ciliary processes?
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What observation would you expect in a person with albinism concerning eye color?
What observation would you expect in a person with albinism concerning eye color?
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What is the primary function of Schlemm's canal?
What is the primary function of Schlemm's canal?
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Which of the following statements accurately describes the sclera?
Which of the following statements accurately describes the sclera?
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What type of epithelium makes up the posterior epithelium of the cornea?
What type of epithelium makes up the posterior epithelium of the cornea?
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What is the composition of the Bruch's membrane?
What is the composition of the Bruch's membrane?
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Which part of the uveal tract is primarily responsible for controlling the shape of the lens?
Which part of the uveal tract is primarily responsible for controlling the shape of the lens?
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How does the cornea receive its nourishment?
How does the cornea receive its nourishment?
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What is a characteristic of the choroid?
What is a characteristic of the choroid?
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Which component of the eye is known for its protective and structural function?
Which component of the eye is known for its protective and structural function?
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Which of the following layers separates the nerve fiber layer from the vitreous body?
Which of the following layers separates the nerve fiber layer from the vitreous body?
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What is the primary function of the ciliary muscles?
What is the primary function of the ciliary muscles?
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Which layer of the retina contains photoreceptor components?
Which layer of the retina contains photoreceptor components?
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What type of connective tissue primarily composes the choroid?
What type of connective tissue primarily composes the choroid?
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How many layers of simple columnar epithelium cover the ciliary body?
How many layers of simple columnar epithelium cover the ciliary body?
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Which part of the ciliary body consists of ridge-like projections?
Which part of the ciliary body consists of ridge-like projections?
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What histological feature can be seen as a thin line aligning between the rods and cones?
What histological feature can be seen as a thin line aligning between the rods and cones?
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What is the primary role of the pigmented layer of the retina?
What is the primary role of the pigmented layer of the retina?
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What is the primary function of the eye?
What is the primary function of the eye?
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Which layer of the eye is responsible for vascular functions?
Which layer of the eye is responsible for vascular functions?
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What is the correct order of the three chambers of the eye from the front to the back?
What is the correct order of the three chambers of the eye from the front to the back?
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Which part of the eye covers the posterior five-sixths?
Which part of the eye covers the posterior five-sixths?
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What is the main characteristic of the corneal stroma?
What is the main characteristic of the corneal stroma?
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What unique feature does the anterior epithelium of the cornea have?
What unique feature does the anterior epithelium of the cornea have?
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Which membrane is responsible for the corneal strength?
Which membrane is responsible for the corneal strength?
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What type of epithelium composes the anterior layer of the cornea?
What type of epithelium composes the anterior layer of the cornea?
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Flashcards
Tunica Fibrosa
Tunica Fibrosa
The outermost layer of the eye, composed of the transparent cornea and the opaque sclera.
Cornea
Cornea
The transparent, convex front part of the eye, responsible for focusing light.
Sclera
Sclera
The opaque, white part of the eye that covers the majority of its surface.
Limbus
Limbus
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Anterior Epithelium
Anterior Epithelium
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Bowmann's Membrane
Bowmann's Membrane
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Corneal Stroma
Corneal Stroma
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Descemet's Membrane
Descemet's Membrane
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What is the cornea?
What is the cornea?
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What is the corneal endothelium?
What is the corneal endothelium?
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What is the Bowman's membrane?
What is the Bowman's membrane?
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What is the sclera?
What is the sclera?
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What is the limbus?
What is the limbus?
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What is Schlemm's canal?
What is Schlemm's canal?
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What is the choroid?
What is the choroid?
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What is Bruch's membrane?
What is Bruch's membrane?
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Choroid
Choroid
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Bruch's Layer
Bruch's Layer
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Pigmented Layer
Pigmented Layer
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Rods and Cones
Rods and Cones
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Outer Nuclear Layer (ONL)
Outer Nuclear Layer (ONL)
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Ciliary Body
Ciliary Body
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Ciliary Muscles
Ciliary Muscles
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What are the functions of ciliary processes?
What are the functions of ciliary processes?
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How do ciliary processes help with lens suspension?
How do ciliary processes help with lens suspension?
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How is Aqueous humor produced?
How is Aqueous humor produced?
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Describe the circulation of aqueous humor.
Describe the circulation of aqueous humor.
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What is the iris and what is its primary function?
What is the iris and what is its primary function?
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What are the layers of the iris?
What are the layers of the iris?
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Describe the structure of the iris stroma.
Describe the structure of the iris stroma.
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What are the epithelial layers of the posterior iris?
What are the epithelial layers of the posterior iris?
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What is the lens in the eye?
What is the lens in the eye?
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What is the Lens Capsule?
What is the Lens Capsule?
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What is the Subcapsule Epithelium?
What is the Subcapsule Epithelium?
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What are Lens Fibers?
What are Lens Fibers?
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What is the suspensory ligament of the lens (Zonule)?
What is the suspensory ligament of the lens (Zonule)?
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What is the vitreous body?
What is the vitreous body?
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What are the two main layers of the retina?
What are the two main layers of the retina?
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What is the function of the retinal pigment epithelium?
What is the function of the retinal pigment epithelium?
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Amacrine cells
Amacrine cells
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Müller's cell
Müller's cell
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Retinal Pigment Epithelium (RPE)
Retinal Pigment Epithelium (RPE)
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Photoreceptor Layer
Photoreceptor Layer
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Outer Limiting Membrane
Outer Limiting Membrane
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Outer Nuclear Layer
Outer Nuclear Layer
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Outer Plexiform Layer
Outer Plexiform Layer
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Inner Nuclear Layer
Inner Nuclear Layer
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Study Notes
Nervous System Module 2020-2021: Histology Lecture 5 - Special Senses: Eye
- The eye is a complex, highly developed photosensitive organ responsible for light reception.
- Each eye is located in a protective bony chamber in the skull, the orbit.
- Histologically, the eye consists of three concentric layers:
- External (fibrous) layer: tunica fibrosa.
- Middle (vascular) layer: tunica vasculosa.
- Internal (nervous) layer: retina.
- The eye has three chambers:
- Anterior chamber: between the cornea and the iris.
- Posterior chamber: between the iris and the lens.
- Vitreous chamber: between the posterior surface of the lens and the neural retina.
The Tunica Fibrosa
- The external layer (tunica fibrosa) is subdivided into sclera and cornea.
- Cornea: a transparent layer covering the anterior one-sixth of the eye.
- Sclera: covers the posterior five-sixths of the eye.
- Limbus: the junction between the cornea and the sclera.
The Cornea
- The most anterior part of the eye, a highly transparent convex structure made of 5 layers:
- Anterior Epithelium (Pavement Epithelium): stratified squamous epithelium (nonkeratinized), consisting of 5-6 cell layers. The basal layer regenerates other cells, corneal epithelial turnover occurs every 7 days, with microvilli. Rich sensory nerve supply.
- Anterior limiting (Bowmann's) membrane: thick basement membrane (8-12 µm) of the epithelium, consists of randomly running collagen fibers, responsible for corneal strength.
- Corneal stroma (Substantia Propria): about 60 layers of parallel, highly organized collagen bundles, contributes to corneal transparency, fibroblast-like cells (keratocytes) with flattened cytoplasmic extensions (like butterfly wings) between collagen fibrills. Proteoglycan-rich extracellular substance. Lymphoid cells are seen in the stroma.
- Posterior limiting (Descemet's) membrane: thick homogenous layer, fine interwoven collagen fibers organized in a 3D network.
- Posterior Epithelium (Cornael Endothelium): simple squamous epithelium, cells showing active transport and protein synthesis.
- The cornea is said to have three cellular layers (epithelial layers and stroma) and two noncellular layers (Bowman's membrane and Descemet membrane).
The Sclera
- The white part of the eye, an opaque layer of dense connective tissue that protects internal structures.
- Relatively avascular, consisting of flattened bundles of type I collagen fibers running in different directions parallel to the eyeball surface, moderate amount of ground substance, and few fibroblasts.
- The innermost layer, adjacent to the choroid, is less dense, with thinner collagen fibers, more fibroblasts, melanocytes, and elastic fibers.
- The sclera thickens posteriorly, reaching 1 mm at the optic nerve attachment and becomes continuous with the epineurium of the nerve.
The Corneoscleral Junction (The Limbus)
- Highly vascularized transitional zone between the cornea and sclera.
- Scleral venous sinus (Schlemm's canal): an irregular endothelium-lined space that communicates with the anterior chamber of the eye, via tiny openings at the iridocorneal angle.
- Schlemm's canal is connected to the venous system and drains the aqueous humor.
- The cornea is avascular and nourished by diffusion from vessels in the limbus and the aqueous humor.
The Tunica Vasculosa (Uveal Tract)
- Consists of three parts: choroid, ciliary body, and iris.
1- The Choroid
- Highly vascularized thin layer, with loose connective tissue between blood vessels.
- Rich in cells, collagen, elastic fibers, and melanocytes (giving the choroid its dark color).
- Suprachoroidal lamina: outer layer beneath the sclera.
- Choriocapillary lamina: inner layer, rich in small blood vessels, major role in retina nutrition.
- Bruch's membrane: hyaline membrane between choriocapillary layer and retina; consists of three layers (elastic fibers network in the middle, & collagen layers on each side). Bruch's membrane covered externally by basement membrane of choriocapillary vessels, and internally by basement membrane of the pigmented epithelium of retina.
2- The Ciliary Body
- Middle part of the uveal tract, extending from ora serrata to the root of the iris.
- Triangular cross-section, with one surface in contact with the sclera, one with the vitreous body.
- Histologically, loose connective tissue rich in blood vessels, elastic fibers, and melanocytes; covered by two layers of simple columnar epithelium derived from the retina:
- First (inner): melanin-rich (pigmented) cells, representing anterior continuation of the pigment epithelium of the retina.
- Second: non-pigmented cells, representing anterior continuation of the sensory layer of the retina.
Ciliary Muscles and Processes
- Ciliary muscles: two bundles of smooth muscle fibers (thick inner circular and thin outer longitudinal layers), important for visual accommodation.
- Ciliary processes: about 75 ridge-like projections from the ciliary body, consisting of loose connective tissue, rich in fenestrated capillaries, and covered by two layers of epithelium.
- Functions of ciliary processes:
- Give attachment to fibers of the suspensory ligament of the lens.
- Secrete aqueous humor (by the non-pigmented epithelium) into the posterior chamber.
Aqueous humor secretion and circulation
- Non-pigmented cells of the ciliary processes have tight junctions and extensive basal membrane.
- They filtrate blood in the ciliary process vessels, secreting aqueous humor.
- Similar to plasma but with minimal proteins.
- Secreted into the posterior chamber, flows via the pupil to the anterior chamber, nourishing the cornea.
- Drains to the venous system via Schlemm's canal through the trabecular meshwork in the iridocorneal angle.
3- The Iris
- Anterior part of the uveal tract (colored part of the eye).
- Disc-like structure with a rounded aperture (pupil) centrally, attached to the ciliary body peripherally.
- Layers:
- Anterior iridial border (anterior surface of the iris): consists of fibroblasts and melanocytes, looks irregular grooved.
- Iris stroma (stroma iridis): loose connective tissue, poorer vascularization in the anterior zone and richer in the posterior zone. Fibroblasts and melanocytes, rich in blood vessels in the posterior zone
- Posterior surface of the iris: smooth surface lined by two epithelial layers, covering the ciliary body.
- Posterior layer (facing the posterior chamber): heavily pigmented cells, preventing light from entering except through the pupil.
- Anterior layer (adjacent to the stroma): less pigmented myoepithelial cells, radially arranged processes forming the dilator pupillae muscle.
The Color of the Eye
- Posterior pigmented epithelium and melanocytes in the iris stroma are responsible for eye color.
- Few melanocytes = blue eyes.
- More melanocytes and collagen = darker eyes.
- Albinism: lack of pigment, visible blood vessels cause pink eyes.
The Lens
- Transparent biconvex structure with great elasticity (decreases with age).
- Components:
- Lens capsule: thick homogenous refractile external layer, representing the basement membrane of lens epithelium.
- Subcapsular epithelium: simple cuboidal or columnar cells lining the anterior half of the capsule, cells divide to form lens fibers.
- Lens fibers: extremely elongated, highly differentiated epithelial cells filling the lens; originate from subcapsular epithelium; lose nuclei and organelles, becoming thin flattened structures filled with proteins (crystallins).
The Suspensory Ligament of the Lens (Zonule)
- Group of radially oriented fibers extending from the ciliary processes to the lens capsule.
- Zonular fibers similar to microfibrils of elastic fibers.
The Vitreous Body
- Transparent, gelatinous medium filling the space between the lens and the retina.
- Composed of 99% water, hyaluronate, and small amounts of collagen.
- Surrounded by the vitreous membrane (made of type IV collagen).
- Contains few macrophages and a small number of hyaluronate-producing cells (hyalocytes) near the membrane.
The Retina (Nervous Layer)
- Consists of two basic layers:
- Neural retina (retina proper): inner layer, containing photoreceptor cells.
- Retinal pigmented epithelium (RPE): outer layer, firmly attached to the choriocapillary layer of the choroid via Bruch's membrane.
- Two regions in the neural retina:
- Non-photosensitive region (nonvisual part): located anterior to the ora serrata; lines the inner aspect of the ciliary body and the posterior surface of the iris.
- Photosensitive region (optic part): lines the inner surface of the eye posterior to the ora serrata, except where it's pierced by the optic nerve.
Types of Cells in the Retina
- Photoreceptor cells (rods and cones)
- Conducting neurons (bipolar and ganglion cells)
- Association neurons (horizontal and amacrine cells)
- Supporting (neuroglial) cells (Müller's cells)
Ten Layers of the Retina
- From outside inward:
- Retinal pigment epithelium (RPE)
- Photoreceptor layer
- Outer limiting membrane
- Outer nuclear layer
- Outer plexiform layer
- Inner nuclear layer
- Inner plexiform layer
- Ganglion cell layer
- Optic nerve fibers layer
- Inner limiting membrane
Accessory Structures of the Eye
- Conjunctiva: Thin, transparent mucosa covering the exposed anterior portion of the sclera and lining the inner surface of the eyelids. Consists of stratified columnar epithelium and goblet cells; supported by a thin lamina propria of loose vascular connective tissue.
- Eyelids: mobile folds of tissue; composed of layers (skin, loose connective tissue containing muscles, tarsal plate, conjunctiva).
Meibomian Glands
- Modified sebaceous glands in the eyelid's tarsal plate.
- Secrete an oily layer onto tear film to prevent rapid evaporation.
Glands of Zeis
- Smaller modified sebaceous glands connected to hair follicles.
Glands of Moll
- Spiral sweat glands opening in hair follicles of the eyelashes.
Accessory Lacrimal Glands
- Krause and Wolfring glands.
Lacrimal Apparatus
- Lacrimal gland: tear-secreting gland located in the antero-supero-lateral orbit.
- Consists of lobes, ducts opening in the superior conjunctiva.
- Tubuloalveolar gland composed of serous columnar cells.
- Tear film: moistens eye, drained by:
- Lacrimal canaliculi: tiny openings at the medial end of the eyelids, uniting to form one canaliculus.
- Lacrimal sac: passes tears to the nasal cavity.
- Nasolacrimal duct: connection to the nasal cavity.
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Description
Test your knowledge on the anatomy and functions of the human eye. This quiz covers components such as the lens, retina, and vitreous body, focusing on their roles and structures. Perfect for students studying biology or anatomy.