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Questions and Answers
What is the normal range for oral temperature at rest?
What is the normal range for oral temperature at rest?
What primarily ensures thermoregulation within the body?
What primarily ensures thermoregulation within the body?
What part of the hypothalamus is responsible for coordinating heat loss?
What part of the hypothalamus is responsible for coordinating heat loss?
What is the primary factor that contributes to the heat production in the body?
What is the primary factor that contributes to the heat production in the body?
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At what temperature do ice crystals begin to form in the human body?
At what temperature do ice crystals begin to form in the human body?
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What could happen to the body if heat loss did not occur during exertion?
What could happen to the body if heat loss did not occur during exertion?
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What is the primary cause of body temperature variations?
What is the primary cause of body temperature variations?
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How does subcutaneous cellular tissue contribute to thermoregulation?
How does subcutaneous cellular tissue contribute to thermoregulation?
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Where are the thermoregulation centers primarily located?
Where are the thermoregulation centers primarily located?
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Which of the following factors does NOT influence the activity of thermoregulation centers?
Which of the following factors does NOT influence the activity of thermoregulation centers?
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What physiological response occurs when body temperature decreases?
What physiological response occurs when body temperature decreases?
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What is the thermostatic reference point for body temperature regulation?
What is the thermostatic reference point for body temperature regulation?
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Which gland's hormones play a role in influencing thermoregulation?
Which gland's hormones play a role in influencing thermoregulation?
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In terms of ages, how do body temperatures vary?
In terms of ages, how do body temperatures vary?
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What happens to the body when temperatures exceed 41°C?
What happens to the body when temperatures exceed 41°C?
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Which type of receptors are found in the anterior hypothalamus?
Which type of receptors are found in the anterior hypothalamus?
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What percentage of heat loss occurs through radiation?
What percentage of heat loss occurs through radiation?
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Which mechanism primarily involves the transfer of heat through air or vacuum?
Which mechanism primarily involves the transfer of heat through air or vacuum?
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Which factor does NOT affect heat loss during evaporation of water?
Which factor does NOT affect heat loss during evaporation of water?
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What role does the sympathetic nervous system play in sweating?
What role does the sympathetic nervous system play in sweating?
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What is the primary method by which blood helps regulate heat loss?
What is the primary method by which blood helps regulate heat loss?
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Which term describes the heat loss mechanism of removing warm air from the skin surface?
Which term describes the heat loss mechanism of removing warm air from the skin surface?
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What does a drop in temperature trigger in the body's response system?
What does a drop in temperature trigger in the body's response system?
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What is one effect of anticholinergic drugs on heat loss?
What is one effect of anticholinergic drugs on heat loss?
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What is the primary effect of shivering on body temperature?
What is the primary effect of shivering on body temperature?
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How does dehydration affect body temperature regulation?
How does dehydration affect body temperature regulation?
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Which of the following hormones increases during cold exposure to aid in thermoregulation?
Which of the following hormones increases during cold exposure to aid in thermoregulation?
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What physiological response occurs when the body temperature rises?
What physiological response occurs when the body temperature rises?
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What is the effect of physical effort on body temperature?
What is the effect of physical effort on body temperature?
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What role do arteriovenous shunts play in thermoregulation?
What role do arteriovenous shunts play in thermoregulation?
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Which mechanism reduces heat loss through the skin during cold exposure?
Which mechanism reduces heat loss through the skin during cold exposure?
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How is the metabolic rate affected by a temperature increase of 0.56°C?
How is the metabolic rate affected by a temperature increase of 0.56°C?
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What is classified as mild hypothermia?
What is classified as mild hypothermia?
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Which of the following is NOT a risk factor for hypothermia?
Which of the following is NOT a risk factor for hypothermia?
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What phase occurs when the internal body temperature drops to 35°C in immersion hypothermia?
What phase occurs when the internal body temperature drops to 35°C in immersion hypothermia?
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Endogenous hypothermia can occur at what ambient condition?
Endogenous hypothermia can occur at what ambient condition?
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Which contributing factor is associated with decreased capacity to conserve heat?
Which contributing factor is associated with decreased capacity to conserve heat?
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What is a potential local effect of cold exposure?
What is a potential local effect of cold exposure?
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Impaired thermoregulation control can result from which condition?
Impaired thermoregulation control can result from which condition?
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What is a significant risk of the critical phase of hypothermia?
What is a significant risk of the critical phase of hypothermia?
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What characterizes hypovolemic heat shock?
What characterizes hypovolemic heat shock?
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Which factors contribute to classical heat shock?
Which factors contribute to classical heat shock?
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What is the primary treatment for heat shock?
What is the primary treatment for heat shock?
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What occurs during the advanced stages of heat shock?
What occurs during the advanced stages of heat shock?
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Which group is at highest risk for exertional heat shock?
Which group is at highest risk for exertional heat shock?
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How does heat affect bodily cells?
How does heat affect bodily cells?
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What is a potential consequence of acute circulatory failure during heat shock?
What is a potential consequence of acute circulatory failure during heat shock?
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In the initial stages of heat shock, what happens to the cardiac output?
In the initial stages of heat shock, what happens to the cardiac output?
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Study Notes
Pathophysiology of the febrile reaction and acclimatization to temperature variation
- The study covers the pathophysiology of febrile reaction and acclimatization to temperature variation.
- Homeothermy involves maintaining a constant internal body temperature, regardless of ambient temperature fluctuations or physical exertion.
- Normal body temperature is around 37 ± 0.6°C, with variations across different measurements (oral, rectal, axillary).
- A typical oral temperature is approximately 36.7°C.
- Rectal temperature readings are typically 0.5°C higher than oral readings.
- Severe or prolonged physical effort can increase body temperature to 38°C.
- The body's temperature fluctuates throughout the day, with lower values in the morning (around 3 a.m.) and higher values in the evening (around 6 p.m.).
- Temperature is the difference between heat production and heat loss.
- Thermoregulation is maintained by the nervous system, blood vessels, skin, and behavioral responses.
- The hypothalamus regulates thermoregulation.
Contents
- Homeothermy
- Febrile reactions
- Acclimatization to heat and hyperthermia
- Acclimatization to cold and hypothermia
- Local effects of cold
Body Temperature Regulation
- The body's core (muscles and viscera) produce most of its heat. Subcutaneous tissues transmit heat one-third less efficiently than other tissues.
- Heat transfer from the core to the skin occurs through blood circulation.
- Without the mechanisms for heat loss, the human body would overheat by 10°C/h during exertion, and 20°C/h.
- The hypothalamus (H) is the central thermoregulatory control center.
- The anterior hypothalamus coordinates heat loss.
- The posterior hypothalamus coordinates heat production.
- There are receptors in the anterior hypothalamus and other areas, sensitive to heat and cold.
Thermoregulation Centers
- Neurons in the anterior hypothalamus are irrigated by a rich vascular network called the OVLT.
- Endothelial cells of the OVLT release arachidonic acid metabolites, producing fever.
- The activity of thermoregulation centers is affected by various stimuli from the periphery, hormones (e.g., thyroxine, corticosteroids), catecholamines, and blood temperature.
Mechanisms for Adapting to Temperature Variations
- For temperature decrease: vasodilation, sweating, decreased heat production.
- For temperature increase: vasoconstriction, piloerection, increased heat production.
- Temperatures outside the 35.8°C to 37.4°C range indicate a thermoregulation failure.
Factors Affecting Body Temperature
- Age
- Gender
- Time of day
- Physical activity
- Environment
- Illness
- Hormones
- Diet
- Hydration
- Sleep
Thermogenesis
- The fight against cold is a chemical mechanism. Shivering increases heat production by 6-7 times.
- Activation of the sympathetic system increases cellular metabolism, releasing adrenaline and noradrenaline when temperature drops, influencing cellular metabolism.
- ATP production decreases, and heat production increases.
- Hypothalamic TRH secretion increases thyroid hormones.
Thermolysis
- Heat loss through the skin, primarily through arteriovenous shunts (like radiators).
- Peripheral vasoconstriction directs blood from superficial to deeper tissues.
- Heat loss through piloerection contractions, conduction, convection, radiation, evaporation, and respiration.
Blood Flow Control
- Blood flow is regulated by the sympathetic nervous system.
- Reducing the exchange surface area via piloerector muscle contraction reduces heat loss.
- Heat loss occurs through conduction (3%), radiation (60%), convection (15%), and evaporation (insensible perspiration, 22%). Heating and humidifying inspired air and urine/feces contribute to heat loss.
Types of Fever
- Intermittent: temperature returns to normal at least once a day, significant differences between morning and evening.
- Remittent: temperature differences greater than 20°C between morning and evening and doesn't return to normal.
- Continuous: temperature variations are less than 1°C.
- Recurrent: episodes of fever alternating with periods of normal temperature.
- Irregular: shows temperature variations of varying degrees and patterns.
ACCLIMATIZATION TO HIGH TEMPERATURES
- Thermolysis is done via cutaneous vasodilation and sweating.
- Decreasing skeletal muscle tone decreases thermogenesis.
- Exceeding adaptation mechanisms results in hyperthermia.
- Examples of heat-related illness include "heat stroke".
Heat Stroke
- Prolonged exposure to direct sunlight and significant overheating.
- Symptoms include headache, dizziness, nausea, and loss of consciousness.
- Core temperature above 40°C. Absence of sweating.
- Heat stroke is a severe thermoregulatory disorder resulting in a significantly high core temperature and lack of sweating.
ACCLIMATIZATION TO LOW TEMPERATURES
- Thermolysis is reduced via cutaneous vasoconstriction.
- Thermogenesis increases via increased skeletal muscle tone (shivering) and increased biological oxidation rate (catecholamines, thyroxine).
- The circulatory changes respond to sympathetic stimulation.
- Excessive adaptation leads to hypothermia.
Hypothermia
- Defined as a decrease in body core temperature below 35°C.
- Can be classified as mild, moderate, or severe based on temperature.
- Risk factors include extreme age, homelessness, malnutrition, chronic alcoholism, mental illness, and use of sedative medication.
- Pathogenesis involves excessive heat loss due to accidental exposure to cold, burns, increased blood circulation in the skin, or reduced metabolic rates.
Local Effects of Cold
- Direct and indirect effects on cells and extracellular fluid.
- Crystallization of water reduces cellular damage in tissues like ligaments and tendons.
- Irreversible denaturation of cell membranes is caused by increased ionic concentration.
- Blood vessel damage can lead to cellular ischemia and hypoxia.
- Vasoactive mediates (like histamine) increase capillary permeability, leading to water retention in interstitium and extensive tissue changes.
Hyperthermia
- A condition characterized by a progressive increase in internal body temperature without any changes to the set point of thermoregulatory centers.
- This disorder can be caused by exposure to a high-temperature external environment (exogenous), or arise internally (endogenous).
- Different types include heat cramps, heat exhaustion, heat syncope, and heat stroke.
Other topics covered include:
- Factors causing febrile reactions (exogenous and endogenous pyrogens).
- Effects of endogenous pyrogens (central and peripheral effects).
- Unfavorable long-term effects (e.g., muscle catabolism and toxic effects).
- Manifestations of febrile reactions (cardiovascular, respiratory, digestive, nervous, metabolic, and humoral).
- Role of fever in the body.
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Test your knowledge on how the human body regulates temperature with this quiz. Learn about factors influencing thermoregulation, temperature variations, and the physiological responses involved. Perfect for students studying human physiology or related fields.