Human Anatomy Quiz on Skin and Hair
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Questions and Answers

What is the name given to the condition characterized by a blue skin color due to low oxygenation of hemoglobin?

  • Cyanosis (correct)
  • Jaundice
  • Erythema
  • Pallor
  • Which of the following skin conditions can be a sign of elevated blood glucose levels?

  • Pallor
  • Erythema
  • Brown or black 'necklace' or bruises (correct)
  • Jaundice
  • What is the primary component of hair?

  • Collagen
  • Elastin
  • Keratin (correct)
  • Melanin
  • Which layer of the hair shaft is composed of overlapping layers of single cells?

    <p>Cuticle (B)</p> Signup and view all the answers

    Which of the following is NOT a function of hair?

    <p>Generating vitamin D (C)</p> Signup and view all the answers

    Which type of keratin is found in hair?

    <p>Hard keratin (D)</p> Signup and view all the answers

    What is the name given to the area within the scalp where keratinization of hair cells is still ongoing?

    <p>Root (A)</p> Signup and view all the answers

    Which of the following areas IS covered in hair?

    <p>Scalp (C)</p> Signup and view all the answers

    What is the primary function of sensible perspiration?

    <p>To regulate body temperature. (D)</p> Signup and view all the answers

    What happens to dermal blood vessels in a cold external environment?

    <p>They constrict to decrease blood flow to the skin. (D)</p> Signup and view all the answers

    Which of the following is an example of a cutaneous exteroreceptor?

    <p>Meissner's corpuscle. (C)</p> Signup and view all the answers

    What is the daily volume of insensible perspiration?

    <p>500 milliliters. (B)</p> Signup and view all the answers

    What is the primary function of melanin in the skin?

    <p>Contributes to skin color and protects against UV damage (B)</p> Signup and view all the answers

    What are striae?

    <p>Silvery white scars caused by extreme stretching of the skin (B)</p> Signup and view all the answers

    Which of the following can be a consequence of prolonged exposure to heavy metals?

    <p>Neurological defects. (B)</p> Signup and view all the answers

    What is the relationship between melanin and UV exposure?

    <p>UV exposure stimulates melanin production, providing greater protection (A)</p> Signup and view all the answers

    Which of the following is a potential negative effect of excessive sun exposure?

    <p>Suppression of the immune system and increased risk of skin cancer (A)</p> Signup and view all the answers

    What is the role of carotene in skin color?

    <p>Gives skin a yellow to orange hue, particularly visible in the palms and soles (C)</p> Signup and view all the answers

    How does hemoglobin contribute to skin color?

    <p>Its color shows through the skin of Caucasians, resulting in a pinkish hue (B)</p> Signup and view all the answers

    What are blisters?

    <p>Fluid-filled pockets that separate the epidermal and dermal layers (C)</p> Signup and view all the answers

    Which of the following substances is necessary for DNA synthesis and is destroyed by UV light?

    <p>Folic acid (C)</p> Signup and view all the answers

    What is the most dangerous type of skin cancer and why?

    <p>Melanoma, because it is highly metastatic and resistant to chemotherapy. (B)</p> Signup and view all the answers

    What is the ABCD rule used for?

    <p>Identifying potential signs of skin cancer. (A)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of a first-degree burn?

    <p>Blistering. (B)</p> Signup and view all the answers

    What is the main reason why the Rule of Nines is used for burns?

    <p>To estimate the extent of the burn. (C)</p> Signup and view all the answers

    Which of the following is a key characteristic of a third-degree burn?

    <p>Gray-white, cherry red or blackened skin. (D)</p> Signup and view all the answers

    What type of cancer is melanoma?

    <p>Cancer of the melanocytes. (A)</p> Signup and view all the answers

    What does the term 'metastatic' mean when referring to cancer?

    <p>The cancer has spread to other parts of the body. (B)</p> Signup and view all the answers

    What is the most common treatment for melanoma?

    <p>Wide surgical excision accompanied by immunotherapy. (C)</p> Signup and view all the answers

    Which of the following contributes to the decreased risk of skin cancer in individuals with younger skin?

    <p>Increased number of melanocytes (C)</p> Signup and view all the answers

    What protective substance is secreted by the sebaceous glands during fetal development?

    <p>Vernix caseosa (A)</p> Signup and view all the answers

    What is the main reason for the increased susceptibility to skin infections and damage in aging individuals?

    <p>Slower epidermal cell replacement (A)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of aging skin?

    <p>Increased sebaceous gland activity (A)</p> Signup and view all the answers

    Why does the skin accumulate more subcutaneous fat during infancy and early adulthood?

    <p>Increased heat production and insulation needs (B)</p> Signup and view all the answers

    What is the primary function of the stratum lucidum?

    <p>Protection from abrasion and penetration (C)</p> Signup and view all the answers

    Which layer of the epidermis is characterized by cells accumulating lamellar granules?

    <p>Stratum granulosum (D)</p> Signup and view all the answers

    How does the process of keratinization begin in the epidermis?

    <p>With the disintegration of nuclei and organelles (B), By the accumulation of keratohyaline granules (C)</p> Signup and view all the answers

    What is the primary function of cells in the stratum corneum?

    <p>Protection from environmental damage (A)</p> Signup and view all the answers

    What is the correct order of the epidermal layers from the innermost to the outermost layer?

    <p>Stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, stratum corneum (B)</p> Signup and view all the answers

    Which of these layers is responsible for the continuous replacement of skin cells?

    <p>Stratum basale (A)</p> Signup and view all the answers

    What causes the cells in the stratum granulosum to die?

    <p>Lack of nutrients from the dermis (C)</p> Signup and view all the answers

    Why is the stratum corneum so important for skin function?

    <p>It acts as a protective barrier against environmental hazards (C)</p> Signup and view all the answers

    Flashcards

    Stratum granulosum

    A thin layer of the epidermis composed of flattened cells undergoing keratinization.

    Keratinization

    The process where skin cells accumulate keratin and other substances to form a protective barrier.

    Keratohyaline granules

    Granules that accumulate in cells during keratinization, aiding in keratin fiber formation.

    Lamellar granules

    Water-resistant glycolipid accumulated by cells, slowing water loss from skin.

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    Stratum lucidum

    A clear layer of the epidermis present in thick skin, consisting of dead, flat keratinocytes.

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    Stratum corneum

    The outermost layer of the epidermis, made up of dead, flattened keratinized cells.

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    Apoptosis

    Controlled cell death leading to the shedding of dead skin cells as dandruff and dander.

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    Cell shedding

    The process where humans lose around 50,000 skin cells per minute.

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    Striae

    Silvery white scars caused by extreme skin stretching.

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    Blisters

    Fluid-filled pockets that separate skin layers due to trauma.

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    Melanin

    A pigment made in skin by melanocytes that determines skin color.

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    Tyrosinase

    An enzyme crucial for the production of melanin from tyrosine.

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    Carotene

    A yellow-orange pigment that can convert to vitamin A.

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    Hemoglobin

    A protein in red blood cells that gives skin its pinkish hue.

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    Photosensitivity

    Increased skin reaction to sunlight due to certain drugs or conditions.

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    UV Light Effects

    Excessive sunlight harms skin, potentially leading to cancer.

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    Cyanosis

    Blue skin color indicating low oxygenation of hemoglobin.

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    Pallor

    Pale skin color; can indicate anemia or fear.

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    Erythema

    Redness of the skin caused by fever or inflammation.

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    Jaundice

    Yellow skin cast indicating liver disorders.

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    Bruises

    Black-and-blue marks from clotted blood beneath the skin.

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    Hair composition

    Hair consists of dead keratinized cells, not found on certain body parts.

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    Parts of hair shaft

    Hair shaft includes medulla, cortex, and cuticle.

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    Hair follicle function

    Hair follicles produce hair and support keratinization.

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    Homeostatic Imbalance

    A condition where normal physiological balance is disrupted, often leading to multiple organ failure.

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    Insensible Perspiration

    Unnoticeable sweat produced by sweat glands under normal conditions, about 500 ml/day.

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    Sensible Perspiration

    Noticeable sweat produced when body temperature rises, can be up to 12 liters (3 gallons).

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    Exteroreceptors

    Sensory receptors that respond to external stimuli like temperature and touch.

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    Free Nerve Endings

    Nerve endings that sense pain and other stimuli, part of the nervous system.

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    Melanoma

    A dangerous skin cancer originating from melanocytes, highly metastatic and resistant to treatment.

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    ABCD Rule

    A guide for early detection of melanoma: Asymmetry, Border irregularity, Color variation, Diameter.

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    Asymmetry (A)

    One side of a pigmented area does not match the other in shape or color.

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    Border Irregularity (B)

    Borders of the mole are uneven or have indentations.

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    Color Variation (C)

    Mole has multiple colors; could be black, brown, tan, red, or blue.

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    Diameter (D)

    Mole larger than 6 mm, about the size of a pencil eraser, raises concerns.

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    Rule of Nines

    A method to estimate burn coverage; the body is divided into sections, each representing 9% except genitalia at 1%.

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    Burn Severity Classes

    Burns are classified into three categories: First-degree, Second-degree, and Third-degree, based on skin damage depth.

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    Lanugo coat

    Delicate hairs covering the fetus in the 5th and 6th month of pregnancy.

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    Vernix caseosa

    A protective secretion from sebaceous glands that covers and protects the fetus's skin in amniotic fluid.

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    Aging skin

    Skin becomes thinner, drier, and more prone to itching and wrinkles due to decreased fat and elasticity.

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    Sebaceous gland activity

    The secretion process increases from infancy to adulthood, which can lead to acne.

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    Delaying aging

    Practices like UV protection, good nutrition, hydration, and hygiene can slow skin aging.

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    Study Notes

    Chapter 05: The Integumentary System

    • The integumentary system comprises skin, hair, nails, sweat glands, and sebaceous glands.
    • Understanding the system is crucial for evaluating and treating skin injuries like burns.

    Why This Matters

    • Knowledge of the integumentary system aids in assessing and managing skin injuries, such as burns.

    Integumentary System

    • The integumentary system encompasses the skin, hair, nails, sweat glands, and oil glands.

    5.1 Structure of Skin

    • Skin consists of two principal regions: the epidermis (outer layer) and dermis (underlying layer).
    • Beneath the dermis lies the hypodermis (not part of skin), primarily composed of adipose tissue. It anchors the skin to underlying structures. The hypodermis aids in cushioning and insulation.
    • The epidermis is avascular, meaning it lacks blood vessels.
    • The dermis is vascular and primarily composed of fibrous connective tissue.

    5.2 Epidermis

    • The epidermis is primarily composed of keratinized stratified squamous epithelium.
    • Four cell types reside within the epidermis:
      • Keratinocytes: Major cells; produce keratin for protective function. Millions of cells constantly slough off.
      • Melanocytes: Produce melanin, a pigment that shields the nucleus from UV damage.
      • Dendritic cells (Langerhans cells): Star-shaped macrophages, crucial components of the immune system, patrol deep epidermis.
      • Tactile cells (Merkel cells): Sensory receptors responsible for tactile sensation.
    • The epidermis is composed of four (thin skin) or five (thick skin) distinct strata (layers):
      • Stratum basale (basal layer)
      • Stratum spinosum (prickly layer)
      • Stratum granulosum (granular layer)
      • Stratum lucidum (clear layer, only in thick skin)
      • Stratum corneum (horny layer)

    Layers of the Epidermis

    • Stratum basale (basal layer): Deepest layer adhering to the dermis, a single layer of stem cells actively dividing (mitotic).
    • Daughter cells migrate toward the surface, undergoing keratinization over 25-45 days.
    • 10-25% of this layer is composed of melanocytes.
    • Stratum spinosum (prickly layer): Multiple layers of keratinocytes connected by desmosomes, exhibiting an irregular appearance. Cells resist tension and pulling.
    • Stratum granulosum (granular layer): Four to six cell layers where cells flatten, nuclei and organelles disintegrate. Keratohyaline granules aid keratin fiber formation. Lamellar granules secrete a hydrophobic substance that retards water loss. Cells stop dividing and die.
    • Stratum lucidum (clear layer): Only present in thick skin and possesses several rows of clear, flat, and dead keratinocytes.
    • Stratum corneum (horny layer): 20-30 layers of dead keratinized cells. This is the outermost and most superficial layer. Although dead, cells provide protection.

    5.3 Dermis

    • The dermis is a strong and flexible connective tissue.
    • It comprises fibroblasts, macrophages, and occasionally mast cells and white blood cells.
    • It forms the "hide" used to create leather.
    • Houses nerves, blood vessels, and lymphatic vessels, as well as hair follicles, sebaceous glands, and sweat glands.
    • It is structured into two layers:
      • Papillary layer (areolar connective tissue)
      • Reticular layer (dense irregular connective tissue)

    Papillary Layer

    • Loose connective tissue with collagen and elastic fibers.
    • Dermal papillae extend into the epidermis.
    • These papillae contain capillaries, nerve endings, and touch receptors (Meissner's corpuscles).
    • In thick skin, dermal papillae rest on dermal ridges, creating epidermal ridges (friction ridges). Ridge patterns form unique fingerprints.

    Reticular Layer

    • Dense fibrous connective tissue.
    • Collagen fibers provide structure and strength, while elastic fibers allow stretch and recoil.
    • Cutaneous plexus of blood vessels exists between this layer and hypodermis.
    • Cleavage (tension) lines run parallel to collagen fibers, influencing surgical incision healing.
    • Flexure lines are dermal folds at or near joints where skin is tightly anchored, and they produce deep creases.

    Clinical-Homeostatic Imbalance 5.1

    • Striae, or stretch marks, are silvery white scars caused by skin stretching.
    • Blistering can occur from acute skin traumas where fluid-filled pockets separate epidermal and dermal layers.

    5.4 Skin Color

    • Skin color is influenced by melanin, carotene, and hemoglobin:
      • Melanin: Produced by melanocytes, ranging from reddish-yellow to brownish-black. It protects against UV damage.
      • Carotene: Yellow-orange pigment accumulating in stratum corneum and hypodermis, convertible to vitamin A, essential for vision and epidermal health.
      • Hemoglobin: Pinkish hue due to lower melanin levels. Skin color of Caucasians is due to hemoglobin showing through the skin.

    Clinical-Homeostatic Imbalance 5.2

    • Sun exposure can lead to skin damage, leather-like texture, immune system depression, potentially causing skin cancer.
    • UV light can destroy folic acid, crucial for embryonic development.
    • Skin hypersensitivity can occur.

    Clinical-Homeostatic Imbalance 5.3

    • Skin color deviations can signal underlying diseases. Examples include:
      • Cyanosis (blue): Low oxygenation
      • Pallor (pale): Anemia, low blood pressure
      • Erythema (red): Fever, allergies
      • Jaundice (yellow): Liver disorders
      • Bruises: Blood clots beneath the skin
      • Brown or black markings: Could indicate insulin resistance or high blood glucose

    5.5 Hair

    • Composed of dead keratinized cells.
    • Absent from palms, soles, lips, nipples, and external genitalia.
    • Functions:
      • Detecting insects
      • Protecting from physical trauma
      • Protecting from heat loss
      • Providing protection from sunlight
    • Hair structures: -Shaft -Root -Medulla -Cortex -Cuticle

    Structure of a Hair Follicle

    • Extends down to the dermis.
    • Contains a bulb where the hair cells are actively produced and replaced.
    • Has a receptor, including nerve endings, to detect touch.
    • Wall consists of peripheral connective tissue sheath (from dermis) and epithelial root sheath (from epidermis).
    • Matrix: actively dividing cells within the bulb that produce new hair cells.
    • Arrector pili muscle attached to follicles.
    • Hair papilla: dermal tissue containing capillaries to supply nutrients.

    Types and Growth of Hair

    • Vellus hair: Fine, pale hair (children and women).
    • Terminal hair: Coarse, long hair (scalp, eyebrows, pubic areas).
    • Hair growth is affected by nutrition and hormones during specific puberty stages.

    Clinical-Homeostatic Imbalance 5.4

    • Women with certain endocrine disorders can have significant excessive amounts of hair, called hirsutism, and other symptoms of masculinization.

    5.6 Nails

    • Scale-like modifications of epidermis with hard keratin.
    • Protect distal, dorsal surface of fingers and toes.
    • Composed of free edge, nail plate, and root.
    • Embedded within the nail bed, the thickened portion of the nail bed, is the nail matrix which is responsible for nail growth.
    • Nail folds surround the nail; the cuticle (eponychium) is a nail fold onto the nail body.
    • Hyponychium is the area beneath the free edge of the nail plate. Nail matrix is visible as the lunule (thickened portion, typically white).

    Clinical-Homeostatic Imbalance 5.6

    • Nail appearance can reflect underlying illnesses or deficiencies; color changes or abnormal shapes can indicate issues like iron deficiency, respiratory or thyroid problems. Beau's lines (horizontal lines) can signal severe diseases, like diabetes, heart attacks, or cancer treatment.

    5.7 Sweat Glands

    • Also called sudoriferous glands.
    • Present across skin surfaces except nipples and external genitalia.
    • Two major types:
      • Eccrine (merocrine): Most numerous, primarily thermoregulation.
      • Apocrine: Larger, associated with hair follicles, and involved in secretions that may play a role as a scent gland. Modified apocrine sweat glands exist as ceruminous glands (earwax) and mammary glands (milk).
    • Myoepithelial cells in sweat glands help force sweat into ducts when stimulated.

    Eccrine Sweat Glands

    • Abundant on palms, soles, and forehead.
    • Involved in thermoregulation (controlled by sympathetic nervous system).

    Apocrine Sweat Glands

    • Found in axillary and anogenital areas.
    • Secrete viscous sweat with fatty substances and proteins.
    • Activated during puberty.

    Sebaceous (Oil) Glands

    • Found everywhere except thick skin (palms and soles).
    • Usually develop from hair follicles.
    • Relatively inactive until puberty, stimulated by hormones.
    • Secrete sebum, an oily substance composed of holocrine secretions, with antibacterial properties, to lubricate and soften hair and skin.

    Clinical-Homeostatic Imbalance 5.7

    • Acne is sebaceous gland inflammation.
    • Whiteheads and blackheads are blocked sebaceous glands.
    • Overactive sebaceous glands in infants manifest as seborrhea (cradle cap).

    5.8 Functions of Skin

    Skin is a protective barrier with many functions:

    • Protection: Multiple levels to physically, chemically, and biologically protect the body from pathogens, chemicals, and damage.
    • Body Temperature Regulation: Sweating and vasoconstriction regulate body temperature via heat loss.
    • Cutaneous Sensations: Receptors detect temperature, pressure, and pain.
    • Metabolic Funtions: Synthesizes vitamin D, converts hormones, and produces collagenase for natural collagen turnover.
    • Blood Reservoir: Holds up to 5% of the body's blood volume for other organs.
    • Excretion: Secretion of nitrogenous wastes (minimal).

    Protection

    • Chemical barrier: Sweat contains antimicrobial proteins, sebum contains defensins. Acidic mantle (low pH) retards bacterial multiplication. Melanin protects against UV radiation.
    • Physical barrier: Flat, dead keratinocytes of stratum corneum, surrounded by glycolipids, create a barrier. Substances like water and water-soluble materials pass over this barrier with difficulty.
    • Biological barrier: Dendritic cells patrol and activate the immune system. Macrophages activate the immune system. DNA absorbs and converts UV radiation into harmless heat.

    Clinical-Homeostatic Imbalance 5.8

    • Organic solvents or heavy metals which are absorbed through the skin can be harmful to multiple organ systems. This can be lethal as a result of organ failure, as well as neurologic defects.

    Body Temperature Regulation

    • Insensible perspiration: About 500ml of daily sweat, normally unnoticed.
    • Sensible perspiration: Increased sweat production (up to 12L) to help with regulating temperature control. This is noticeable as sweat due to higher sweat volume.
    • Dermal vasoconstriction to curtail heat loss.

    Cutaneous Sensations

    • Cutaneous sensory receptors respond to stimuli outside the body, such as temperature and touch.
    • Free nerve endings sense painful stimuli.

    Metabolic Functions

    • Skin synthesizes vitamin D for calcium absorption in the intestine.
    • Skin chemicals neutralize some carcinogens.
    • Keratinocytes convert hormones (like cortisone) to other forms.
    • Skin makes collagenase to regulate collagen turnover.

    Blood Reservoir

    • Skin can store up to 5% of the body's total blood volume.
    • Blood can be shunted to other areas (e.g., exercise muscles).

    Excretion

    • Skin secretes limited amounts of nitrogenous wastes (such as ammonia, urea, and uric acid).
    • Sweating causes salt and water loss.

    5.9 Skin Cancer and Burns

    • Skin can develop various conditions including infections and cancers.
    • Skin cancer types include Basal cell carcinoma, Squamous cell carcinoma, and Melanoma; Each has varying severity and treatment.
    • Burns are categorized by severity (first, second, third-degree) and classified as critical if >25% of the body contains second-degree burns, or if >10% of the body contains third-degree burns (especially involving face, hands, or feet).

    Skin Cancer

    • Basal cell carcinoma: Least malignant and most common. Involves stratum basale, slow spread. Usually cured by excision.
    • Squamous cell carcinoma: Second most common. Involves cells of stratum spinosum. Usually scaly lesions on sun-exposed areas. Good prognosis with treatment.
    • Melanoma: Most serious, highly malignant, and often metastasizes. Key to survival is early detection using ABCD rule (asymmetry, border irregularity, color, and diameter).

    Burns

    • Tissue damage by heat, electricity, radiation, or chemicals. Leading causes of immediate tissue damage and dehydration.
    • Classified by degree of severity (first, second, and third degree), which depend on epidermal and dermal damage.
    • Critical burns are those where >25% of the body's surface has second-degree burns, or where >10% of the body's surface is third-degree burns (especially on face, hands, or feet). This severity often requires debridement, antibiotics, temporary coverings, and/or skin grafts.

    Developmental Aspects of the Integumentary System

    • Fetal: Lanugo (fine hairs) and vernix caseosa (sebum) protect the developing fetus in amniotic fluid.
    • Infancy to Adulthood: Skin thickens, subcutaneous fat increases, sebaceous and sweat gland activity increases.
    • Aging: Epidermal replacement slows, skin becomes drier, less elastic, more susceptible to skin cancers, and can also experience hair thinning.

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