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Questions and Answers
Which of the following is NOT a component of the external ear?
Which of the following is NOT a component of the external ear?
The primary function of the tympanic membrane (eardrum) is to:
The primary function of the tympanic membrane (eardrum) is to:
The auditory ossicles in the middle ear are arranged in which order from the tympanic membrane to the oval window?
The auditory ossicles in the middle ear are arranged in which order from the tympanic membrane to the oval window?
Why is the middle ear connected to the nasopharynx via the auditory tube (eustachian tube)?
Why is the middle ear connected to the nasopharynx via the auditory tube (eustachian tube)?
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Which of the following is NOT true about the cochlea?
Which of the following is NOT true about the cochlea?
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What is the primary function of the vestibular apparatus?
What is the primary function of the vestibular apparatus?
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Which of the following is the most accurate description of the membranous labyrinth?
Which of the following is the most accurate description of the membranous labyrinth?
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Why is the internal ear called the bony labyrinth?
Why is the internal ear called the bony labyrinth?
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What is the primary role of the tip links in the mechanical transduction of sound at hair cells?
What is the primary role of the tip links in the mechanical transduction of sound at hair cells?
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Which of the following events directly leads to an increase in the frequency of action potentials (APs) in the afferent neurons innervating hair cells?
Which of the following events directly leads to an increase in the frequency of action potentials (APs) in the afferent neurons innervating hair cells?
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The myosin-based molecular motor in the taller stereocilia plays a crucial role in:
The myosin-based molecular motor in the taller stereocilia plays a crucial role in:
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Which of the following statements regarding the ionic composition of endolymph and perilymph is FALSE?
Which of the following statements regarding the ionic composition of endolymph and perilymph is FALSE?
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Why is the recycling of K+ ions entering the hair cell through mechanically-sensitive ion channels essential?
Why is the recycling of K+ ions entering the hair cell through mechanically-sensitive ion channels essential?
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A drug that blocks voltage-gated Ca2+ channels in hair cells would most likely result in:
A drug that blocks voltage-gated Ca2+ channels in hair cells would most likely result in:
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Which of the following is NOT a direct consequence of increased bending of stereocilia in the direction of the taller stereocilia?
Which of the following is NOT a direct consequence of increased bending of stereocilia in the direction of the taller stereocilia?
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How does the mechanical transduction process at hair cells differ from the way photoreceptor cells respond to light?
How does the mechanical transduction process at hair cells differ from the way photoreceptor cells respond to light?
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What is the relationship between the frequency of a sound and the location on the basilar membrane where it causes maximum displacement?
What is the relationship between the frequency of a sound and the location on the basilar membrane where it causes maximum displacement?
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How does the amplitude of a sound wave affect the response of the basilar membrane?
How does the amplitude of a sound wave affect the response of the basilar membrane?
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What role do hair cells play in auditory transduction?
What role do hair cells play in auditory transduction?
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Which of these is NOT a component of the pathway that transmits auditory information from the cochlea to the brain?
Which of these is NOT a component of the pathway that transmits auditory information from the cochlea to the brain?
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How does the brain encode the intensity of a sound?
How does the brain encode the intensity of a sound?
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Which of the following is MOST responsible for the ability to distinguish between different frequencies of sound?
Which of the following is MOST responsible for the ability to distinguish between different frequencies of sound?
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What is the primary function of Wernicke's area in the auditory pathway?
What is the primary function of Wernicke's area in the auditory pathway?
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What is the relationship between the basilar membrane and the scala vestibuli?
What is the relationship between the basilar membrane and the scala vestibuli?
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Which of the following conditions is NOT a potential cause of conductive hearing loss?
Which of the following conditions is NOT a potential cause of conductive hearing loss?
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Which of the following is a common symptom of both conductive and sensorineural hearing loss?
Which of the following is a common symptom of both conductive and sensorineural hearing loss?
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Which of the following groups is most likely to experience a significant risk of sensorineural hearing loss due to acoustic trauma?
Which of the following groups is most likely to experience a significant risk of sensorineural hearing loss due to acoustic trauma?
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How do ototoxic drugs contribute to sensorineural hearing loss?
How do ototoxic drugs contribute to sensorineural hearing loss?
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What is the primary function of the stria vascularis in the inner ear?
What is the primary function of the stria vascularis in the inner ear?
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Which of the following is a potential genetic factor contributing to presbycusis?
Which of the following is a potential genetic factor contributing to presbycusis?
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Which of the following scenarios would be LEAST likely to contribute to sensorineural hearing loss?
Which of the following scenarios would be LEAST likely to contribute to sensorineural hearing loss?
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Based on the provided information, which of the following statements about dental professionals and hearing loss is TRUE?
Based on the provided information, which of the following statements about dental professionals and hearing loss is TRUE?
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The organ of Corti is located in which chamber of the cochlea?
The organ of Corti is located in which chamber of the cochlea?
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If a person sustains an injury to their vestibular branch of the vestibulocochlear nerve (CN VIII), which of the following symptoms would they likely experience?
If a person sustains an injury to their vestibular branch of the vestibulocochlear nerve (CN VIII), which of the following symptoms would they likely experience?
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A sound wave with a high frequency is characterized by:
A sound wave with a high frequency is characterized by:
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Which of the following best describes the process of sound transduction in the ear?
Which of the following best describes the process of sound transduction in the ear?
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What is the relationship between the amplitude of a sound wave and its perceived loudness?
What is the relationship between the amplitude of a sound wave and its perceived loudness?
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A person with a hearing impairment may struggle to understand speech because they have difficulty perceiving sounds within what frequency range?
A person with a hearing impairment may struggle to understand speech because they have difficulty perceiving sounds within what frequency range?
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Which of the following statements about endolymph and perilymph is TRUE?
Which of the following statements about endolymph and perilymph is TRUE?
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Imagine two sound waves, one with a frequency of 1000 Hz and another with a frequency of 5000 Hz. Which of the following is TRUE about these two sounds?
Imagine two sound waves, one with a frequency of 1000 Hz and another with a frequency of 5000 Hz. Which of the following is TRUE about these two sounds?
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A sound wave with a larger amplitude will be perceived as:
A sound wave with a larger amplitude will be perceived as:
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Study Notes
Special Senses II: Hearing & Balance
- The ear is divided into external, middle, and inner ear.
- Vestibulocochlear nerve (CN VIII) is involved in hearing and equilibrium.
- CN VIII has two branches: cochlear (hearing) and vestibular (equilibrium and balance).
- The external ear consists of the pinna (auricle), outer ear canal, and eardrum (tympanic membrane).
Learning Objectives
- Describe the components and functions of the external, middle, and inner ear.
- Explain the role of the tympanic membrane, auditory ossicles (malleus, incus, stapes), and cochlea scala vestibules in sound transmission.
- Describe the structure and location of hair cells in the inner ear.
- Describe how sound waves are transduced into nerve impulses in hair cells in the organ of Corti.
- Explain how pitch and loudness are coded in the auditory pathways.
- Compare causes of conductive and sensorineural hearing loss.
- Explain how hair cells in the semicircular canals detect head rotation.
- Explain how hair cells in the saccule and utricle detect gravity and head tilt.
- Describe the neural auditory and vestibular pathway from hair cell receptors to the cerebral cortex.
The Ear (Diagram)
- The outer ear consists of the external acoustic meatus and tympanic membrane.
- The middle ear consists of the malleus, incus, and stapes (auditory ossicles), oval window, round window and eustachian tube.
- The inner ear consists of the cochlea, vestibular nerve and cochlear nerve.
External Ear
- Structures: pinna (auricle), outer ear canal, tympanic membrane (eardrum).
- Function: captures sound waves, directs them toward the middle ear, acts like a directional antenna, directs sound waves down the air-filled outer ear canal, and the tympanic membrane vibrates with the movement of sound waves.
Middle Ear
- Structures: malleus, incus, stapes (auditory ossicles).
- Function: convey sound waves across the air-filled middle ear, from the tympanic membrane to a smaller drum of the inner ear (oval window), malleus attached to tympanic membrane, incus articulates with malleus and stapes, stapes is attached to the inner ear at the oval window, where sound waves are transferred to the inner ear, and middle ear is connected to nasopharynx by auditory tube (eustachian tube) helps equalize air pressure across the tympanic membrane.
Inner Ear
- Structure and function: entirely enclosed within the temporal bone, two main fluid-filled organs: cochlea (hearing receptors) and vestibular apparatus (equilibrium receptors).
- Cochlea: contains receptors (hair cells) for hearing.
- Vestibular apparatus: contains receptors (hair cells) for equilibrium.
- The internal ear is called the bony labyrinth due to its complex shape.
- A bony channel structure encompasses the membranous labyrinth.
- The membranous labyrinth is filled with endolymph fluid.
- Perilymph fluid surrounds the membranous labyrinth.
Vestibulocochlear Nerve (CN VIII)
- The cochlea and vestibular apparatus are connected to the brain stem via the vestibular cochlear nerve (CN VIII).
- CN VIII provides special sensory innervation for hearing and equilibrium.
- CN VIII has two branches: auditory branch to the cochlea (hearing), and vestibular branch to the semicircular canal (equilibrium & balance).
- Injury to CN VIII can result in: deafness, tinnitus (ringing in the ear), and vertigo (loss of balance).
What is Sound?
- Sound is produced when something vibrates.
- The vibration produces a series of pressure waves - sound waves.
- When these pressure waves reach the ear, the ear transduces this mechanical stimulus (pressure wave) into a nerve impulse (electrical signal) that the brain perceives as sound.
Qualities of Sound
- Sound waves have four major features: waveform, phase, amplitude, frequency.
- Loud sound is generated by large vibrations generating large air pressure waves.
- Soft sound is generated by small vibrations.
- In humans, amplitude corresponds to loudness.
- High-frequency sounds are generated from rapid vibrations and have closely spaced pressure waves.
- Low-frequency sounds are generated from slow vibrations, and have longer wavelengths.
- In humans, frequency relates to pitch.
- The normal range of frequencies audible to humans is 20 to 20,000 Hz.
- The amplitude of a sound wave is directly correlated with loudness expressed in decibels (dB).
- The frequency of a sound wave is directly correlated with the pitch of a sound, expressed in Hertz (Hz).
Sound Waves (Diagram)
- Different wave forms represent different sounds.
Sound Transmission
- Sound waves cause the tympanic membrane to vibrate.
- Vibrations are transferred from the malleus to incus to stapes to the oval window.
- Sound waves are converted into fluid motion in the inner ear.
The Cochlea & the Organ of Corti
- Cochlea: spiral shaped fluid-filled structure, three chambers (scalae): scala vestibuli, scala media, scala tympani.
- Scala vestibuli - perilymph (low K+).
- Scala media - endolymph (K+-rich fluid).
- Scala tympani - perilymph (low K+).
- Organ of Corti: located in the scala media (middle chamber).
Organ of Corti
- The organ of Corti lies along the entire length of the basilar membrane of the cochlea.
- The organ of Corti contains the hair cells, receptors for transducing sound waves into nerve impulses.
- Hair cells are auditory receptors.
- Hair cells are located on the basilar membrane with the tips of the hair cells that are embedded in the tectorial membrane.
Organ of Corti - Hair Cells
- Hair cells are named for their tufts of stereocilia.
- Stereocilia emerge from the apical surface of hair cells.
- The stereocilia are embedded in the tectorial membrane.
- At the basal end, hair cells are in contact with the auditory nerve (CN VIII).
Sound Transduction
- Hair cells are arranged in four rows: 3 rows of outer hair cells and 1 row of inner hair cells.
- Approximately 25,000 hair cells in each human cochlea.
- Sound waves (converted to fluid motion) cause the basilar membrane to flex.
- Hair cell stereocilia bend via the shearing motion with the (tectorial) membrane.
- This lateral shearing motion opens mechanosensitive K+ ion channels.
- Receptor potentials are generated.
- Ultimately APs are produced in the CN VIII nerve.
Mechanical Transduction at Hair Cell Stereocilia
- Tip links connect to K+ channels, bending the stereocilia stretches the tip link.
- Tip links function like a hinged trapdoor.
- When the cilia are bent by the shearing motion with the tectorial membrane, tip links mechanically open the K+ channels.
- The influx of K+ and depolarization initiate the receptor potential.
- A myosin-based molecular motor moves the ion channels, releasing the tension of the tip link and K+ channel closes.
Mechanical Transduction at Hair Cells
- The more stereocilia bend in the direction of the taller stereocilia (bending into direction of kinocilium), the more K+ channels are open.
- This results in an increased depolarization, increased Ca2+ entry, increased neurotransmitter release, and increased AP frequencies in afferent neurons.
Ionic Composition of Endolymph and Perilymph
- Mechanoelectrical transduction of sound is highly dependent on the ionic composition of the fluids bathing the sensory hair cells.
- Perilymph: low K+, scala vestibuli and scala tympani.
- Endolymph: high K+, scala media.
- Stereocilia protrude into the K+ rich endolymph, and the basal end is bathed in perilymph.
- Electrochemical gradient necessary for K+ influx, generates the depolarizing receptor potentials.
- K+ that enters the hair cells is recycled.
Coding Sound Intensity and Pitch
- A traveling wave sweeps down the basilar membrane.
- The basilar membrane is narrow and stiff near the oval window; wide and floppy at the apex.
- Thus, areas of the basilar membrane vibrate differently for different sound frequencies.
- High frequency sounds maximally displace the basilar membrane near the oval window.
- Low frequency sounds maximally displace at the apex.
- Different parts of the basilar membrane are sensitive to different frequencies.
- Loud sounds produce increased AP frequency; most complex sounds contain multiple frequencies.
Auditory Neural Pathway
- Sensory hair cells, cochlear branch of auditory nerve (CN VIII), brainstem, thalamus, auditory cortex.
- Acoustical information processed by the brain at various levels.
- Auditory association areas, Wernicke's area (comprehending speech).
- Broca's area (understanding language).
Sound Transduction - Summary
- Hearing is the transduction of sound waves into electrical signals (APs in the auditory nerves).
- Pressure changes produced by sound waves are reproduced as vibrations on the tympanic membrane and ossicles.
- These vibrations set up fluid wave motion in the inner ear.
- Traveling fluid waves cause the basilar membrane flexing; this moves the tectorial membrane laterally over the hair cells.
- Lateral shearing motion bends stereocilia, pulls on the tip links, and opens the mechanosensitive K+ ion channels.
- Receptor potentials are generated due to K+ influx and subsequent APs generated in the CN VIII nerve.
Hearing Loss
- Conductive hearing loss: refers to any blockage of sound from reaching the hair cells, i.e., impaired conduction of sound, causes (wax, foreign bodies, otitis externa, otitis media), treated with hearing aids.
- Sensorineural hearing loss: occurs when hair cells or nerves are damaged, (CN VIII auditory nerve), treated with cochlear implant.
Hearing Loss (Causes)
- Acoustical trauma: extremely loud sounds (explosives, gunfire), repeated exposure to industrial or household noise.
- Infections - otitis media.
- Ototoxin drugs: loop diuretics, certain antibiotics, chemotherapies
- Presbycusis: gradual hearing loss associated with aging (e.g., atherosclerosis, genetics)
Hearing Loss & Dentistry
- Noise levels in dental settings, between 65-93 dB, found to annoy and impact hearing of dental students.
- 80% of students experienced noise annoyance; 54% reported hearing problems; 10% reported hearing loss.
Vestibular System
- 5 vestibular structures of the membranous labyrinth, 3 semicircular ducts (horizontal, posterior, superior) 2 otolith organs(saccule & utricle), function in equilibrium.
- Each semicircular canal is dilated (ampulla) contains a sensory area (cupula).
- The utricle and saccule have a sensory area (macula), utricle communicates with the saccule and fluid contains otoliths (calcium carbonate particles).
Vestibular System (Essential Tasks)
- Monitor the orientation and position of the body.
- Pathways to the cortex to perceive gravity and movement.
- Hair cells in distinct sensory regions in each inner ear.
- Semicircular canals in the ampulla region detect head rotation.
- Hair cells in the macula of the saccule and utricle detect linear acceleration in the vertical and horizontal directions, respectively.
Vestibular Hair Cells
- Hair cell bundles have specific orientations and are responsive to fluid displacements in all directions.
- The three semicircular canals are oriented approximately 90 degrees to each other for maximum ability to detect angular rotation of the head.
Head Rotation
- The ampulla is a dilation at one end of each semicircular canal.
- The crista ampullaris sits at the base of the ampulla and contains a patch of innervated hair cells (receptors).
- The cupula sits on top of the crista, filling the lumen of the semicircular duct.
- When the head turns, fluid in the semicircular canal pushes against the cupula, bending the stereocilia, exciting the hair receptors, and movement of fluid is opposite to the head rotation.
- Fluid in the semicircular ducts moves in the opposite direction, inhibiting the hair receptors.
Horizontal & Vertical Equilibrium
- Within the saccule and utricle, the macula is the region where hair cells are located.
- When the head is upright, the macula are vertically oriented in the saccule and horizontally in the utricle.
- Hair cell stereocilia are embedded in a gelatinous otolithic membrane.
- Otoliths (tiny crystals) float in the gel, and their movement causes the hair cells to bend.
- Hair cells contact the CN VIII at the basal end.
- Hair cell bundles have specific orientations and are responsive to displacements in all directions.
- In the utricle & saccula, an area called the striola divides the hair cells into two populations with opposing polarities.
Transduction Mechanism by Vestibular Hair Cells
- Vestibular hair cells transduce minute head movements into receptor potentials.
- The mechanism is similar to the auditory system.
- A mechanical stimulus bends the stereocilia of the hair cells (K+ channels).
- Bending the stereocilia stretches the tip link.
- Causes an influx of K+ ions, leading to AP generation in CN VIII.
- Vestibular hair cells have one tall stereocilia termed the kinocilium.
- Bending the stereocilia toward the kinocilium depolarizes the cell, and bending away from the kinocilium hyperpolarizes the cell..
Vestibular Neural Pathway
- Cell bodies of neurons that supply the vestibular branch of CN VIII are located in the vestibular ganglion.
- From these vestibular nuclei, fibers project to the cerebellum, the primary somatosensory cortex, and tracts that mediate head and body adjustments (contralateral spinal cord and cranial nerves).
- Reflexes to maintain posture, control eye movements, and conscious awareness in "space".
Summary
- The ear houses receptors for hearing and equilibrium.
- The external, middle, and cochlea of the inner ear are involved in hearing; the semicircular canals, utricle, and saccule are involved in equilibrium.
- Hearing & equilibrium rely on hair cells.
- Six locations of hair cells in each inner ear: 1 in each of the three semicircular canals, 1 in the utricle, 1 in the saccule, and 1 in the cochlea.
- Hair cell receptors have different functions in detecting head rotation, horizontal linear acceleration, and vertical linear acceleration, respectively.
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Test your knowledge about the anatomy and functions of the human ear with this quiz. It covers components of the external ear, middle ear structures, and the roles of various parts in hearing and balance. Perfect for students studying human anatomy.