Human Anatomy and Reproduction Quiz

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Questions and Answers

What is the diploid number of chromosomes in germ line cells?

  • 23
  • 92
  • 46 (correct)
  • 69

What type of division occurs in germ line cells to produce gametes?

  • Meiosis (correct)
  • Binary Fission
  • Bud Formation
  • Mitosis

How many chromosomes do gametes contain after division?

  • 46 chromosomes
  • 34 chromosomes
  • 15 chromosomes
  • 23 chromosomes (correct)

Which process contributes to genetic variability during meiosis?

<p>Independent Assortment (A)</p> Signup and view all the answers

Which of the following statements about haploid and diploid cells is correct?

<p>Diploid cells contain more genetic information than haploid cells. (A)</p> Signup and view all the answers

What is the haploid number of chromosomes found in each gamete?

<p>23 chromosomes (B)</p> Signup and view all the answers

What happens to the chromosome number at fertilization?

<p>It restores to diploid number (D)</p> Signup and view all the answers

During which phase of meiosis does chromosomal crossover primarily occur?

<p>Prophase I (A)</p> Signup and view all the answers

What structure connects sister chromatids after chromosome replication?

<p>Centromere (A)</p> Signup and view all the answers

Which of the following best describes the difference between haploid and diploid cells?

<p>Haploid cells contain one set of chromosomes, diploid cells two sets. (D)</p> Signup and view all the answers

What is the primary outcome of the separation phase during meiosis?

<p>Separation of homologous pairs into two daughter cells (A)</p> Signup and view all the answers

How does meiosis contribute to genetic variability?

<p>By allowing for crossing over and independent assortment (B)</p> Signup and view all the answers

Which term correctly describes cells with one complete set of chromosomes?

<p>Haploid (D)</p> Signup and view all the answers

What is the chromosome composition of daughter cells produced at the end of meiosis?

<p>Haploid, with half the chromosome number of the parent cell (B)</p> Signup and view all the answers

What occurs during chromosomal crossover in meiosis?

<p>Homologous chromosomes exchange segments of genetic material (C)</p> Signup and view all the answers

What is the primary purpose of meiosis in germ cells?

<p>To reduce the chromosome number to the haploid number (A)</p> Signup and view all the answers

During which stage of meiosis do cells replicate their DNA?

<p>At the beginning of meiosis I (B)</p> Signup and view all the answers

How many types of meiosis are there?

<p>Two types (C)</p> Signup and view all the answers

What does meiosis achieve in terms of chromosome sets?

<p>It reduces the chromosome number to one set (C)</p> Signup and view all the answers

What cell type do primordial germ cells develop into?

<p>Oogonia (A)</p> Signup and view all the answers

What process do diploid oogonia undergo during early fetal development?

<p>Mitosis (B)</p> Signup and view all the answers

What significant event occurs to most germ cells before birth?

<p>They degenerate by atresia (B)</p> Signup and view all the answers

What is the ploidy level of oogonia?

<p>Diploid (2n) (D)</p> Signup and view all the answers

How do diploid oogonia contribute to the number of germ cells before birth?

<p>They divide by mitosis to produce millions (B)</p> Signup and view all the answers

What is the primary process that occurs during fertilization?

<p>The fusion of male and female gametes (A)</p> Signup and view all the answers

Which statement about in vitro fertilization is accurate?

<p>It can utilize gametes preserved for many years (D)</p> Signup and view all the answers

What is the result of the fusion of male and female gametes?

<p>Development of a zygote (B)</p> Signup and view all the answers

Which component is essential for fertilization to occur?

<p>Compatibility of gametes (D)</p> Signup and view all the answers

What is the significance of gametes being frozen for long durations in the context of in vitro fertilization?

<p>It allows for indefinite storage without effect on viability (B)</p> Signup and view all the answers

What happens to the morula once it enters the uterine cavity?

<p>Fluid penetrates through the zona pellucida. (D)</p> Signup and view all the answers

What is formed as a result of fluid penetrating the inner cell mass?

<p>The blastocyst. (B)</p> Signup and view all the answers

What is the role of the zona pellucida during the morula's development?

<p>It allows fluid entry into the intercellular spaces. (B)</p> Signup and view all the answers

Which cell structure is involved in the interaction between the morula and the uterine cavity?

<p>Intercellular spaces. (D)</p> Signup and view all the answers

What type of tissues does the inner cell mass of the blastocyst eventually contribute to?

<p>All germ layers. (D)</p> Signup and view all the answers

What is the role of hyaluronidase during fertilization?

<p>To assist in the penetration of the zona pellucida (A)</p> Signup and view all the answers

Which of the following enzymes are involved in the lysis of the zona pellucida?

<p>Acrosin, esterases, &amp; neuraminidase (A)</p> Signup and view all the answers

What is the end result of the fusion of plasma cell membranes in fertilization?

<p>Creation of a diploid zygote (D)</p> Signup and view all the answers

What is the significance of acrosomal enzymes in sperm function?

<p>They facilitate penetration of the zona pellucida (C)</p> Signup and view all the answers

Which of the following processes occurs after the zona pellucida is lysed?

<p>Sperm has a direct path to the oocyte (A)</p> Signup and view all the answers

What is the zona reaction responsible for during fertilization?

<p>Making the zona pellucida impermeable to additional sperm (D)</p> Signup and view all the answers

What occurs at the completion of the second meiotic division of the oocyte?

<p>The formation of a mature ovum and a second polar body (A)</p> Signup and view all the answers

Which change in the zona pellucida is crucial for preventing polyspermy?

<p>Alteration in the molecular structure of the zona (C)</p> Signup and view all the answers

What is the outcome of the second meiotic division in oogenesis?

<p>One large ovum and a smaller polar body are produced (B)</p> Signup and view all the answers

How does the zona reaction impact the fertilization process?

<p>It prevents further sperm from entering after the first sperm has fertilized the ovum (B)</p> Signup and view all the answers

What occurs during prophase of mitosis?

<p>Chromosomes begin to coil and condense (A)</p> Signup and view all the answers

Which stage of mitosis is characterized by the alignment of chromosomes at the equatorial plane?

<p>Metaphase (B)</p> Signup and view all the answers

What major event occurs during anaphase of mitosis?

<p>Chromatid migration to opposite poles (C)</p> Signup and view all the answers

At which stage of mitosis do daughter cells begin to form?

<p>Telophase (D)</p> Signup and view all the answers

What is the primary role of mitotic spindles during mitosis?

<p>To separate sister chromatids (C)</p> Signup and view all the answers

What is the function of the kinetochore during cell division?

<p>To attach spindle fibers to chromosomes (A)</p> Signup and view all the answers

What is located at the centromere of a chromosome?

<p>The point where sister chromatids are held together (B)</p> Signup and view all the answers

Which statement accurately describes a kinetochore?

<p>It is a protein complex where spindle fibers attach (C)</p> Signup and view all the answers

During which cellular process is the kinetochore specifically active?

<p>Cell division (C)</p> Signup and view all the answers

What is the primary role of the centromere in relation to sister chromatids?

<p>To connect the sister chromatids during division (A)</p> Signup and view all the answers

What is the typical number of sperm that can enter the uterus during reproduction?

<p>200-600 million (D)</p> Signup and view all the answers

What characteristic of sperm allows them to travel through the vagina effectively?

<p>Highly motile properties (B)</p> Signup and view all the answers

What role does the isthmus play in the journey of sperm?

<p>It aids in the peristaltic movement of sperm. (D)</p> Signup and view all the answers

In which part of the female reproductive system do sperm become highly motile?

<p>Vagina (A)</p> Signup and view all the answers

Why is the motility of sperm critical for reproduction?

<p>It allows sperm to reach the egg quickly. (D)</p> Signup and view all the answers

What is the process called where homologous chromosomes align themselves in pairs during meiosis?

<p>Synapsis (A)</p> Signup and view all the answers

How do homologous chromosomes align themselves during synapsis?

<p>They align in pairs, point for point. (C)</p> Signup and view all the answers

Which chromosome combination is noted as an exception during the pairing of homologous chromosomes?

<p>XY (C)</p> Signup and view all the answers

What is a characteristic of the alignment of homologous chromosomes during synapsis?

<p>It is exact and point for point. (B)</p> Signup and view all the answers

Which of the following statements is true about synapsis during meiosis?

<p>It is essential for the pairing of homologous chromosomes. (D)</p> Signup and view all the answers

What is formed when the intercellular spaces become confluent during embryonic development?

<p>Blastocyst (D)</p> Signup and view all the answers

Which term describes the cavity that forms within the blastocyst during early embryonic development?

<p>Blastocele (D)</p> Signup and view all the answers

At what stage does an embryo become a blastocyst?

<p>When the blastocele forms (A)</p> Signup and view all the answers

What developmental stage follows the merging of intercellular spaces in embryogenesis?

<p>Blastocyst (A)</p> Signup and view all the answers

Which structure is indicative of the transition into the stage of a blastocyst in embryology?

<p>Blastocele (C)</p> Signup and view all the answers

What is the primary event that occurs during implantation?

<p>The penetration of the trophoblastic layer into the endometrium (A)</p> Signup and view all the answers

On which days does the process of implantation typically start and complete?

<p>6th-8th day and completed by the 12th day (A)</p> Signup and view all the answers

What is the state of the endometrium during implantation?

<p>Thick and nutrient-rich to support the developing embryo (C)</p> Signup and view all the answers

What is the role of the trophoblast during the implantation process?

<p>To facilitate the entry of the blastocyst into the uterine lining (D)</p> Signup and view all the answers

Which statement accurately describes the timing of implantation?

<p>It initiates on the 6th day and concludes by the 12th day (D)</p> Signup and view all the answers

What term describes stem cells that can differentiate into various cell types?

<p>Pluripotent (C)</p> Signup and view all the answers

Which anatomical term refers to the front of the body?

<p>Anterior (D)</p> Signup and view all the answers

What is the diploid number of chromosomes in somatic cells?

<p>46 (B)</p> Signup and view all the answers

In embryonic terminology, which term refers to the tail end of the body?

<p>Caudal (D)</p> Signup and view all the answers

Which type of cell division do somatic cells undergo?

<p>Mitosis (C)</p> Signup and view all the answers

What is the primary function of the kinetochore during cell division?

<p>To facilitate the movement of chromosomes (D)</p> Signup and view all the answers

Which of the following statements is true about the centromere?

<p>It is the region where sister chromatids are joined. (A)</p> Signup and view all the answers

What role do spindle fibers serve in relation to the kinetochore?

<p>They attach to the kinetochore for chromosomal movement. (B)</p> Signup and view all the answers

What happens to sister chromatids after the centromere divides?

<p>They are pulled apart toward opposite poles of the cell. (C)</p> Signup and view all the answers

Which structure is required for the attachment of spindle fibers during mitosis?

<p>Kinetochore (D)</p> Signup and view all the answers

At what stage of life does spermatogenesis begin in males?

<p>At puberty (A)</p> Signup and view all the answers

What is the duration required for spermatogenesis to complete one cycle?

<p>64 days (D)</p> Signup and view all the answers

During which phase does oogenesis resume in females?

<p>At puberty (A)</p> Signup and view all the answers

When do females begin the process of gametogenesis?

<p>During the fetal period (A)</p> Signup and view all the answers

What transformation occurs in spermatogenesis?

<p>Spermatogonia into spermatozoa (A)</p> Signup and view all the answers

What is a primary result of the crossover that occurs during meiotic divisions?

<p>Redistribution of genetic material leading to genetic variability (A)</p> Signup and view all the answers

How does meiosis contribute to the genetic diversity of daughter cells?

<p>Through the process of genetic recombination (D)</p> Signup and view all the answers

What occurs to the chromosomes in the daughter cells at the end of meiotic divisions?

<p>Each daughter cell receives different combinations of chromosomes (B)</p> Signup and view all the answers

Which statement accurately describes the outcome of meiotic divisions?

<p>Four genetically different daughter cells are produced (B)</p> Signup and view all the answers

Which process is primarily responsible for the genetic variability observed in daughter cells after meiosis?

<p>Crossover and genetic recombination (B)</p> Signup and view all the answers

Which structure facilitates fluid penetration in the morula?

<p>Zona pellucida (A)</p> Signup and view all the answers

Which of the following best describes the function of the zona pellucida in early development?

<p>Protecting the inner cell mass from external factors (D)</p> Signup and view all the answers

Which component of the morula is primarily involved in the formation of tissues in the embryo?

<p>Inner cell mass (A)</p> Signup and view all the answers

What process occurs when homologous chromosomes align themselves in pairs during meiosis?

<p>Synapsis (C)</p> Signup and view all the answers

Which statement is true regarding the alignment of homologous chromosomes during synapsis?

<p>It is exact and point for point except for XY combinations. (B)</p> Signup and view all the answers

What distinguishes the alignment of XY chromosomes from other homologous pairs during synapsis?

<p>They align differently, lacking point-for-point pairing. (D)</p> Signup and view all the answers

Which aspect of synapsis contributes to the genetic diversity in gametes?

<p>Point-for-point alignment and potential crossover. (A)</p> Signup and view all the answers

What is the main significance of the exact and point-for-point pairing of homologous chromosomes during meiosis?

<p>To facilitate accurate genetic recombination. (C)</p> Signup and view all the answers

What is the first stage in the development of sperm cells from spermatogonia?

<p>Spermatocytogenesis (B)</p> Signup and view all the answers

During meiosis, what type of cells are directly produced from spermatocytes?

<p>Haploid spermatids (B)</p> Signup and view all the answers

What is the ploidy level of spermatogonia before they undergo spermatocytogenesis?

<p>Diploid (B)</p> Signup and view all the answers

What is the primary characteristic of the cells produced after meiosis in spermatogenesis?

<p>They contain a single copy of each chromosome. (D)</p> Signup and view all the answers

Which process occurs after spermatocytogenesis and before the formation of mature sperm?

<p>Meiosis (B)</p> Signup and view all the answers

What is the maximum time frame during which an oocyte must be fertilized to avoid degeneration?

<p>12 hours (C)</p> Signup and view all the answers

What physiological process has increased activity without any morphological changes in the uterus or uterine tubes?

<p>Fertilization (C)</p> Signup and view all the answers

What happens to oocytes that are not fertilized within a certain period?

<p>They degenerate (A)</p> Signup and view all the answers

In which part of the female reproductive system does the fertilization of an oocyte predominantly occur?

<p>Uterine tubes (C)</p> Signup and view all the answers

What is a key consequence of fertilization occurring beyond the viable time frame for an oocyte?

<p>Degeneration of the oocyte (B)</p> Signup and view all the answers

What role does the syncytiotrophoblast play during implantation?

<p>It facilitates the embedding of the blastocyst into the endometrium. (B)</p> Signup and view all the answers

What occurs immediately after the blastocyst becomes embedded in the endometrium?

<p>Closure of the implantation site by a fibrin clot. (D)</p> Signup and view all the answers

Which description best fits the function of the multinucleated protoplasmic mass formed during implantation?

<p>It has a phagocytic function for debris clearance. (C)</p> Signup and view all the answers

What significant change occurs to the uterine wall after the blastocyst's embedment?

<p>Regeneration of surface epithelial cells covering the implantation site. (B)</p> Signup and view all the answers

Which process is primarily facilitated by the syncytiotrophoblast during early pregnancy?

<p>Digestion of uterine tissue. (C)</p> Signup and view all the answers

What does it mean for an embryo to be viable?

<p>It is able to survive independently outside the uterus. (C)</p> Signup and view all the answers

Which description aligns with the term 'viable' in embryonic development?

<p>Capable of independent function without maternal support. (D)</p> Signup and view all the answers

At what stage is an embryo considered viable?

<p>When it has reached sufficient maturity to survive outside the uterus. (B)</p> Signup and view all the answers

What is a primary result of meiotic divisions that contributes to the diversity of daughter cells?

<p>Crossover that redistributes genetic material (B)</p> Signup and view all the answers

Which statement accurately describes the chromosomal content of the daughter cells after meiosis?

<p>Each daughter cell contains a unique combination of chromosomes (C)</p> Signup and view all the answers

Why is viability an important concept in developmental biology?

<p>It indicates the point at which an embryo can survive away from maternal resources. (C)</p> Signup and view all the answers

How does the concept of viability influence pregnancy outcomes?

<p>It influences decisions around prenatal care and intervention strategies. (D)</p> Signup and view all the answers

Which mechanism primarily ensures genetic variability during the process of meiosis?

<p>Independent assortment of homologous chromosomes (B)</p> Signup and view all the answers

Which of the following correctly describes the genetic material distribution in the daughter cells post-meiosis?

<p>Random distribution leading to diverse genetic combinations (A)</p> Signup and view all the answers

What aspect of meiosis primarily contributes to the genetic differences between the four daughter cells?

<p>The occurrence of chromosomal crossover (D)</p> Signup and view all the answers

What is the first phase that sperm encounters during fertilization that is critical for its passage?

<p>Corona radiata (D)</p> Signup and view all the answers

Which enzyme is specifically mentioned as playing a role in the fertilization process related to the sperm?

<p>Hyaluronidase (C)</p> Signup and view all the answers

What is the primary function of the hyaluronidase enzyme during the fertilization process?

<p>To lyse the zona pellucida (D)</p> Signup and view all the answers

In the context of fertilization, what structure must the sperm penetrate first after leaving the male body?

<p>Cumulus layers (C)</p> Signup and view all the answers

Which of the following sequences is indicative of the initial interaction of sperm with the egg during fertilization?

<p>Navigating corona radiata then acrosome reaction (C)</p> Signup and view all the answers

Germ line cells have a haploid number of chromosomes equal to 23.

<p>False (B)</p> Signup and view all the answers

Meiosis results in gametes that possess the diploid number of chromosomes.

<p>False (B)</p> Signup and view all the answers

A germ cell divides by mitosis to produce gametes.

<p>False (B)</p> Signup and view all the answers

During meiosis, each germ cell divides twice to produce four gametes.

<p>True (A)</p> Signup and view all the answers

The diploid number of chromosomes in humans is represented as 1n.

<p>False (B)</p> Signup and view all the answers

Spermatogenesis in males begins as early as the age of 10.

<p>False (B)</p> Signup and view all the answers

Oogenesis in females begins during the fetal period and resumes at puberty.

<p>True (A)</p> Signup and view all the answers

The process of spermatogenesis requires approximately 45 days to complete.

<p>False (B)</p> Signup and view all the answers

Gametogenesis in males and females occurs at the same developmental stage.

<p>False (B)</p> Signup and view all the answers

Transformation of spermatogonia into spermatozoa is a lengthy process that can take up to two months.

<p>True (A)</p> Signup and view all the answers

After puberty, meiosis I resumes in several secondary follicles, with only one follicle maturing fully to produce three haploid cells.

<p>False (B)</p> Signup and view all the answers

Meiosis I results in the formation of two diploid cells.

<p>False (B)</p> Signup and view all the answers

The secondary oocyte is the only cell that resumes meiosis after puberty.

<p>True (A)</p> Signup and view all the answers

One of the outcomes of meiosis I is the production of identical sister chromatids.

<p>False (B)</p> Signup and view all the answers

At the end of meiosis I, a secondary oocyte and a polar body are formed, both carrying genetic variations.

<p>True (A)</p> Signup and view all the answers

The primary follicle develops into a secondary follicle when a cavity known as the antrum begins to form.

<p>True (A)</p> Signup and view all the answers

In the formation of a secondary follicle, the cells surrounding the oocyte release a solid substance instead of fluid into the antrum.

<p>False (B)</p> Signup and view all the answers

The emergence of the antrum is a definitive characteristic that marks the follicle as a primary follicle.

<p>False (B)</p> Signup and view all the answers

As the follicle matures and becomes a secondary follicle, the oocyte remains unchanged and does not undergo any developmental stages.

<p>False (B)</p> Signup and view all the answers

Cells around the oocyte cease to function once the follicle transforms into a secondary follicle.

<p>False (B)</p> Signup and view all the answers

A secondary oocyte is a small cell that cannot be seen by the naked eye.

<p>False (B)</p> Signup and view all the answers

The secondary oocyte remains in metaphase until fertilization occurs.

<p>True (A)</p> Signup and view all the answers

After fertilization, the secondary oocyte will not resume meiosis II.

<p>False (B)</p> Signup and view all the answers

The trophoblast is the inner cell layer of the late blastocyst that develops into the embryonic part of the placenta.

<p>False (B)</p> Signup and view all the answers

At puberty, a female's ovary contains approximately 1 million mature secondary oocytes ready for ovulation.

<p>False (B)</p> Signup and view all the answers

The zona pellucida is a covering of material that surrounds the secondary oocyte during follicle development.

<p>True (A)</p> Signup and view all the answers

The zona pellucida is shed during the hatching process of the late blastocyst on day 5.

<p>True (A)</p> Signup and view all the answers

On day 5 of development, blastomeres in the late blastocyst give rise to the mesoderm layer.

<p>False (B)</p> Signup and view all the answers

The late blastocyst stage is characterized by the formation of the inner cell mass, which eventually contributes to the embryonic structures.

<p>True (A)</p> Signup and view all the answers

The trophoblast layer is responsible for the initial establishment of the embryo's nutrition supply.

<p>True (A)</p> Signup and view all the answers

Flashcards

Germ line cells

Cells that produce gametes (sperm or egg cells) through meiosis.

Diploid number

A cell containing two sets of chromosomes (2n).

Haploid number

A cell containing one set of chromosomes (1n).

Meiosis

Cell division process that produces gametes with half the number of chromosomes.

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Gametes

Reproductive cells (sperm and egg) that have a haploid number of chromosomes.

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Chromosome separation

Homologous pairs separate into two daughter cells, reducing the chromosome number.

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Diploid to haploid

The chromosome number goes from double to single.

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Homologous pairs

Matching chromosome pairs.

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Daughter cells

The two new cells produced from cell division.

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Chromosome number reduction

The number of chromosomes is cut in half from diploid to haploid.

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Haploid number of chromosomes

A single set of chromosomes, found in gametes (sex cells).

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Diploid number of chromosomes

Two sets of chromosomes, found in somatic cells (body cells).

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Fertilization

Union of gametes (sperm and egg).

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Centromere

Region where sister chromatids are joined after chromosome replication.

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Primordial germ cells

Special cells in the developing embryo that are destined to become either sperm or eggs.

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Oogonia

Early female germ cells that are diploid, containing two sets of chromosomes.

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Mitosis in oogonia

Oogonia divide by mitosis, a process that creates genetically identical copies of the cell. This produces a large pool of germ cells.

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Atresia

The process where most oogonia degenerate before birth, leading to a significant decrease in the number of germ cells.

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Diploid oogonia

Oogonia contain two complete sets of chromosomes, making them diploid (2n).

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Acrosome

A cap-like structure on the head of a sperm cell containing enzymes that help the sperm penetrate the egg's outer layer.

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Hyaluronidase

An enzyme found in the acrosome of sperm that breaks down hyaluronic acid, a component of the egg's outer layer.

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Zona Pellucida

The thick, glycoprotein layer surrounding the egg cell.

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Acrosomal Enzymes

Enzymes released from the acrosome, like acrosin, esterases, and neuraminidase, that dissolve the zona pellucida, allowing the sperm to reach the egg.

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Plasma Membrane Fusion

The merging of the sperm's outer membrane with the egg's outer membrane.

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Zona Reaction

Changes in the zona pellucida (ZP) that make it impermeable to other sperm. This prevents multiple sperm from fertilizing a single egg.

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Second Meiotic Division

The second division in meiosis that occurs in the oocyte after fertilization. It produces a haploid egg cell with one set of chromosomes.

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What protects the egg from multiple sperm?

The zona pellucida (ZP), a protective coating surrounding the egg, undergoes changes after fertilization (zona reaction) to prevent additional sperm from entering.

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Haploid egg cell

The mature egg cell produced after the second meiotic division, containing only one set of chromosomes.

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What events happen during fertilization?

Fertilization involves the union of a sperm and an egg. It triggers the zona reaction, preventing further sperm entry. It also initiates the second meiotic division of the oocyte, culminating in the production of a haploid egg cell.

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Blastocyst

A hollow ball of cells formed from the morula, consisting of an inner cell mass and an outer layer called the trophoblast.

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Inner cell mass

The cluster of cells inside the blastocyst that will eventually develop into the embryo.

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Trophoblast

The outer layer of cells surrounding the blastocyst that will form the placenta.

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Fluid penetration

The process by which fluid enters the morula through the zona pellucida, creating the blastocyst.

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DNA Replication in Meiosis

Before meiosis I begins, the cell replicates its DNA, creating sister chromatids for each chromosome.

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In-vitro fertilization

Fertilization that occurs outside of the body, allowing the union of sperm and egg in a controlled laboratory setting.

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Zygote formation

The single-celled stage of a new organism formed by the fusion of a sperm and an egg.

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Gamete freezing

The process of preserving sperm or eggs at very low temperatures for later use.

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Fertilization trigger

The fusion of sperm and egg initiates a series of events in the egg, including changes to the zona pellucida.

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What is a kinetochore?

A protein complex on the chromosome where spindle fibers attach during cell division, allowing chromosomes to be pulled apart.

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Spindle Fibers

Microtubules that extend from the poles of the cell during cell division and attach to kinetochores on chromosomes, pulling them apart.

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Centromere function

The region where sister chromatids (copied chromosomes) are joined together. This is the central point of attachment for the kinetochore.

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Sister Chromatids

Two identical copies of a chromosome created during DNA replication, connected at the centromere.

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Kinetochore's Role

The kinetochore ensures that chromosomes are correctly attached to spindle fibers and pulled apart during cell division, ensuring that each new cell gets a full set of chromosomes.

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Prophase

The first stage of mitosis, where chromosomes condense and become visible, the nuclear envelope breaks down, and the mitotic spindle begins to form.

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Metaphase

The stage of mitosis where chromosomes line up along the center of the cell, attached to the mitotic spindle fibers.

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Anaphase

The stage of mitosis where sister chromatids (identical copies of chromosomes) are pulled apart by the spindle fibers to opposite poles of the cell.

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Telophase

The final stage of mitosis where two daughter nuclei form, the chromosomes uncoil, and the cytoplasm divides to form two new cells.

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Homologous chromosome pairing

During synapsis, homologous chromosomes align themselves in pairs. This pairing is exact, matching point for point, except for the XY combination.

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Synapsis

The process where homologous chromosomes pair up during meiosis I, forming tetrads (groups of four chromatids).

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XY combination

The sex chromosomes, X and Y, are not completely homologous. This means they don't pair up perfectly like other chromosome pairs.

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Tetrads

Groups of four chromatids formed during synapsis, where homologous chromosomes pair up.

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Sperm's Journey

Sperm travel from the vagina, through the cervix and uterus, and finally into the fallopian tubes where fertilization might happen.

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Peristaltic Movement

Muscle contractions in the fallopian tubes, like waves, propel the sperm towards the egg.

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Sperm Count

The average number of sperm in a healthy male ejaculate is 200-600 million.

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Highly Motile

Sperm are very active and can move independently.

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Fertilization Site

Fertilization usually occurs in the fallopian tubes, where sperm meet the egg.

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Blastocyst Formation

A hollow ball of cells (blastocyst) forms as intercellular spaces merge during early embryonic development.

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What is a blastocyst?

A hollow ball of cells, formed from the morula, consisting of an inner cell mass (embryo) and a trophoblast (placenta).

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Implantation

The process where a blastocyst burrows into the endometrium of the uterus, establishing pregnancy.

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Endometrium

The inner lining of the uterus, which thickens during the menstrual cycle to prepare for implantation.

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When does implantation occur?

Implantation typically begins around the 6th-8th day after fertilization and is complete by the 12th day.

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Human Embryonic Stem Cells

Cells derived from the inner cell mass of a blastocyst, capable of differentiating into any cell type in the body.

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Pluripotent

Describing a cell that can develop into many different cell types in the body.

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Anterior

The front or ventral surface of the body.

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Posterior

The back or dorsal surface of the body.

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Somatic Cell

Any cell in the body except germ cells (sperm and egg cells).

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Kinetochore

A protein complex that attaches to the centromere of a chromosome during cell division, serving as the point of attachment for spindle fibers.

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What does the kinetochore do during cell division?

The kinetochore is essential for the correct attachment of chromosomes to spindle fibers, ensuring they are pulled apart to opposite poles of the cell during cell division. This ensures each daughter cell receives a full set of chromosomes.

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Genetic variability

The process of creating different combinations of genes in offspring through meiosis.

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Crossover

The exchange of genetic material between homologous chromosomes during meiosis I.

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Redistributes genetic material

Crossover shuffles genes between homologous chromosomes, creating unique combinations in daughter cells.

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Why is genetic variability important?

Genetic variability increases the chances of survival in a changing environment by creating diverse offspring.

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What is the result of crossover?

Crossover leads to unique combinations of genes in the gametes (sperm and egg) produced during meiosis, increasing genetic diversity in offspring.

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What is different about homologous chromosomes during synapsis?

Except for the XY combination, homologous chromosomes align perfectly point-for-point.

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Homologous chromosomes

Matching chromosome pairs, one from each parent.

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Spermatogenesis

The process by which sperm cells are produced in the testes, starting at puberty.

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Oogenesis

The process by which egg cells are produced in the ovaries, starting during fetal development and resuming at puberty.

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Spermatogenesis duration

The complete process of spermatogenesis takes approximately 2 months (64 days).

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What is the difference between spermatogenesis and oogenesis?

Spermatogenesis begins at puberty and produces millions of sperm cells continuously, while oogenesis starts before birth, stops during meiosis I, and resumes at puberty, producing only a limited number of eggs.

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When does spermatogenesis begin?

Spermatogenesis begins at puberty, typically between the ages of 13 and 16 years old.

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Morula

A solid ball of cells formed after several cell divisions of the fertilized egg.

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Viable

A fertilized egg that is mature enough to survive outside the uterus.

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What happens during fertilization?

Fertilization is when a sperm cell and an egg cell fuse. It triggers the zona reaction, preventing other sperm from entering. The egg then begins the process of cell division.

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Meiosis's Role

Meiosis is a cellular division process that creates gametes (sperm and eggs) with half the number of chromosomes compared to somatic cells. This ensures that when a sperm and egg fuse during fertilization, the offspring receives the correct number of chromosomes.

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Genetic Variability in Meiosis

Genetic variability in offspring is achieved through meiosis, particularly through crossover. Crossover is the exchange of genetic material between homologous chromosomes, leading to unique gene combinations in the gametes.

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Spermatocytogenesis

The process where primitive sperm cells (spermatogonia) divide and grow into spermatocytes. It's the first stage of spermatogenesis.

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Meiosis in Spermatogenesis

The division of spermatocytes (2n) into haploid cells (spermatids, 1n). This happens in two phases: Meiosis I and Meiosis II.

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Spermatids

Haploid cells produced after meiosis. They are the precursors to mature sperm cells.

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What is the role of the acrosome?

The acrosome is a cap-like structure on the head of a sperm cell, containing enzymes that help the sperm penetrate the egg's outer layer (zona pellucida) during fertilization.

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Fertilization Time Limit

Sperm must fertilize an egg within 12 hours of ovulation. After 24 hours, the egg will degenerate and become unable to be fertilized.

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Fertilization Location

Fertilization typically occurs in the fallopian tubes, where sperm meet the egg cell.

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What happens to an unfertilized egg?

If an egg is not fertilized within 24 hours, it will degenerate and break down in the body.

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Fertilization's Role

Fertilization is the essential step for creating a new individual. It marks the beginning of pregnancy and triggers the developmental journey of a fertilized egg.

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Corona Radiata

The outer layer of cells surrounding the egg, composed of cumulus cells that provide nutrients and support.

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What triggers the zona reaction?

The fusion of the sperm's plasma membrane with the egg's plasma membrane triggers the zona reaction.

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Blastocyst Implantation

The process where the blastocyst embeds itself into the endometrium of the uterus, marking the start of pregnancy.

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Syncytiotrophoblast

A multinucleated layer of cells that forms from the trophoblast, playing a crucial role in implantation and nutrient exchange.

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Fibrin Clot

A blood clot that forms at the site of implantation, sealing the opening and preventing further bleeding.

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Surface Epithelium

The outer layer of cells covering the endometrium, which heals over the original defect caused by blastocyst implantation.

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Phagocytic Function

The ability of certain cells, like the syncytiotrophoblast, to engulf and digest foreign particles or cellular debris.

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Spermatogenesis start

The process of sperm cell production in males begins at puberty, usually between 13 and 16 years old.

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Oogenesis Timing

Egg cell production in females starts during fetal development but pauses during meiosis I and resumes at puberty.

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What are spermatids?

Haploid cells produced after meiosis in spermatogenesis. They are the precursors to mature sperm cells.

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Acrosome's role

The acrosome, a cap on the sperm head, contains enzymes that help sperm penetrate the egg's outer layer during fertilization.

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Secondary Oocyte

A large cell produced during oogenesis, visible to the naked eye. It stops at metaphase II of meiosis until fertilization occurs.

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What happens if fertilization doesn't occur?

The secondary oocyte will degenerate (break down) and be reabsorbed by the body.

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How many primary oocytes are present at birth?

A newborn female ovary contains around 1 million primary oocytes.

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How many mature oocytes are ovulated during a woman's life?

Only around 400 mature secondary oocytes are ovulated during a woman's lifetime.

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Secondary follicle

A follicle that has developed a cavity (antrum) filled with fluid, secreted by cells surrounding the oocyte.

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Antrum

The fluid-filled cavity within a secondary follicle, which develops as cells around the oocyte secrete a fluid.

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What happens in the secondary follicle?

In the secondary follicle, cells surrounding the oocyte secrete a fluid, creating a cavity called the antrum. This is a crucial step in follicle development, preparing the oocyte for ovulation.

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What is the purpose of the antrum?

The antrum serves as a space for fluid accumulation within the secondary follicle. This fluid provides nourishment for the oocyte and plays a role in the development and eventual release of the mature egg cell.

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Fluid secretion in follicle development

The secretion of fluid by cells around the oocyte creates the antrum, a critical step in the transformation of a primary follicle into a secondary follicle.

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First Polar Body

A small, non-functional cell produced along with the secondary oocyte during meiosis I in a secondary follicle.

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Meiosis I in Secondary Follicle

After puberty, meiosis I resumes in several secondary follicles. This process leads to the formation of a secondary oocyte and the first polar body.

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One Mature Secondary Follicle

Although several secondary follicles begin meiosis I, only one will mature fully into an egg cell.

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Haploid Cells

The secondary oocyte and the first polar body are both haploid cells, containing half the usual number of chromosomes.

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Meiosis: Reducing Chromosomes

Meiosis is a cell division process that reduces the number of chromosomes in a cell by half. This is crucial for creating haploid gametes from diploid germ cells.

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Gametes: The Sex Cells

Gametes are the reproductive cells, sperm and egg, that have a haploid number of chromosomes (1n). They are produced from germ cells through meiosis.

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Fertilization: Joining Gametes

Fertilization is the union of a sperm and an egg. It combines the haploid chromosomes from each gamete, creating a diploid zygote with the full number of chromosomes.

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Zygote: The First Cell

The zygote is the single-celled stage of a new organism. It is formed by the fusion of a sperm and egg during fertilization, combining the genetic material from both parents.

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Hatching Blastocyst

A blastocyst that has shed its zona pellucida, allowing it to implant in the uterine wall.

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Blastocyst Differentiation

The process by which the blastocyst's cells specialize into two distinct layers: the trophoblast and the inner cell mass.

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Zona Pellucida (ZP)

A thick, glycoprotein layer surrounding the egg cell that protects it and helps guide sperm to fertilize it.

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Study Notes

Trimester

  • Pregnancy is divided into 3 calendar months, 9 total months.
  • Abortion is the expulsion of an embryo or fetus before it's viable.
  • Viable means mature enough to survive outside the uterus.

Directional Terminology and Body Planes

  • Anatomical position:
    • Anterior/Posterior
    • Superior/Inferior
    • Lateral/Medial
    • Caudal/Cranial
    • Dorsal/Ventral
    • Sagittal plane
    • Coronal section
    • Frontal plane
    • Transverse section

Types of Cells

  • Somatic cells have 2 sets of chromosomes (diploid number = 46) and divide by mitosis.
  • Germ cells also have 2 sets of chromosomes (diploid number = 46) and divide by meiosis to produce gametes.
  • Gametes have 1 set of chromosomes (haploid number = 23).
  • Embryonic gametes form in the epiblast, then migrate to the yolk sac and gonads.
  • Humans have 23,000 genes on 46 chromosomes.
  • In somatic cells, chromosomes appear as 23 homologous pairs.
  • 22 pairs are autosomes, and 1 sex pair (XX = female, XY = male).
  • Each gamete (egg/sperm) has 23 chromosomes.
  • Fertilization restores the diploid number of 46 chromosomes.
  • Centromere: connects sister chromatids after chromosome replication.
  • Kinetochore: protein complex where spindle fibers attach during cell division.

Cell Division

  • Mitosis: produces 2 identical daughter cells.
    • DNA replicates before mitosis.
    • Prophase, Prometaphase, Metaphase, Anaphase, Telophase, Daughter cells
    • Chromosomes condense and become visible.
    • Spindle fibers attach to chromosomes.
    • Chromosomes line up at the middle of the cell.
    • Sister chromatids separate.
    • New nuclei form, and cytoplasm divides.
  • Meiosis: specialized cell division for creating gametes.
    • Results in 4 daughter cells with half the number of chromosomes as the parent cell (haploid).
    • Two stages: Meiosis I and Meiosis II
    • Includes crossover: exchange of chromatid segments between paired homologous chromosomes
    • Genetic variation
    • Random distribution of homologous chromosomes

Gametogenesis

  • Spermatogenesis (male): production of sperm, begins at puberty, occurs continuously, takes place in the seminiferous tubules of the testes.
  • Oogenesis (female): production of eggs, begins before birth, occurs cyclically, takes place in the ovaries.
  • These processes have multiple stages, important for cell division and maturation, and each has distinct phases and timing.

Transport (Reproduction)

  • Sperm travels from the epididymis to the vagina via peristaltic movement.
  • Secretions from glands form semen.
  • Millions of sperm are produced (200 - 600 million).
  • Sperm mobility is high.
  • Oocyte moves through the Fallopian tubes.
  • Fimbriae aid movement and guidance.

Fertilization

  • Fusion of male and female gametes
  • Occurs in the ampulla of fallopian tube.
  • Sperm must penetrate the corona radiata and zona pellucida.
  • Fusion triggers completion of meiosis II in the egg
  • Formation of the zygote.

Cleavage of the Zygote

  • Repeated mitotic divisions of the zygote.
  • Formation of blastomeres
  • Blastomeres compact.
  • Morula
  • Blastocyst
  • Implantation: blastocyst implants in the uterine endometrium.
  • Blastocyst has two main parts:
    • Trophoblast outer layer
    • Inner Cell Mass (embryoblast): will develop into the embryo.
    • Blastocyst is in the uterine cavity for about 5 days
    • The zona pellucida degrades

Blastogenesis

  • Early stages of embryo development
  • Formation of the blastocyst with the 2 main cell groups (trophectoderm and inner cell mass).
  • Zygote undergoes division forming a blastula and then blastocyst to implantation in uterine wall.

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