Hudson-Kreitman-Aguade test

What does the McDonald-Kreitman (MK) test compare to determine if a gene is evolving neutrally?

According to the neutral theory of molecular evolution, what should be true about the evolutionary rate of a gene?

What can a significant p-value in the MK test (i.e. p < 0.05) suggest about the evolution of a gene?

What does it mean if the ratio of non-synonymous to synonymous substitutions within a species is less than the ratio between species in the MK test?

What is the purpose of the HKA (Hudson-Kreitman-Aguadé) test?

Which of the following is not a characteristic of the neutral theory of molecular evolution?

What does an insignificant p-value in the MK test for Positive Selection suggest?

When the rate of evolution is GREATER within species than between species, what could it indicate?

What is the significance of the HKA test in genetics?

In the context of Positive Selection, what does a reduced rate of variation within species due to a sweep suggest?

If the rate of evolution is ~equal within and between species, what evolutionary process does it suggest?

What could be a possible reason for redoing tests on only polymorphisms at medium frequency (>10% in population)?

What is the purpose of the HKA test?

According to the neutral theory of molecular evolution, what is the relationship between the number of segregating sites (S) within a species and the number of divergent sites (D) between species?

What does the HKA test assume about the effective population size ($N_e$) and mutation rate ($ u$) across multiple genes?

If the HKA test rejects the null hypothesis of neutral evolution, what does this indicate?

What is the purpose of comparing the level of polymorphism within a species to the level of divergence between species?

How does the HKA test use the number of segregating sites (S) within a species and the number of divergent sites (D) between species to test for neutral evolution?