21 Questions
What is the main function of activator proteins in eukaryotic transcriptional regulation?
Promote transcription
How do repressor proteins contribute to gene expression regulation in eukaryotes?
Block transcription
What distinguishes eukaryotic regulation from bacterial regulation in terms of control mechanisms?
Eukaryotes primarily use positive control mechanisms
In the context of gene expression, what constitutes a key factor for ensuring the correct amount of gene product in a cell?
Regulated transcription with appropriate timing and quantity
What is a characteristic of the regulatory proteins involved in eukaryotic transcriptional regulation?
Form large complexes in eukaryotes
How do levels of RNA transcripts contribute to controlling the amount of each protein or RNA in a eukaryotic cell?
By influencing the amount of gene product synthesis
What is responsible for the phenomenon of co-suppression in petunias?
dsRNA
Which molecules are processed by DICER and RISC in the context of gene regulation?
dsRNA
What is the function of RISC-RNA complexes in gene regulation?
Degrade targeted RNAs
Which process can lead to gene silencing based on the given information?
Changes to DNA methylation
In the context of gene regulation, what does RNAi-based drugs treat?
Hereditary transthyretin amyloidosis
What is responsible for binding to the UASG sites in yeast when galactose is present?
Gal4
Which protein interacts with Gal4 to keep it inactive when galactose is absent?
Gal80
What is the function of the SAGA complex in gene regulation?
Recruits Mediator
Which region of DNA contains the TATA box and binds RNA polymerase II in eukaryotic transcription?
Core promoter region
What is the main role of enhancer sequences in eukaryotic gene regulation?
Regulate transcription from a distance
What prevents the DNA-binding domain of Gal4 from binding to UASG sites when galactose is absent?
Gal80 interaction
Which protein forms a homodimer and interacts with Gal80 in yeast gene regulation?
Gal4
What type of protein binds to the core promoter region that contains the TATA box?
RNA polymerase II
What is the role of silencer sequences in gene regulation?
Inhibit transcription
How do enhancers regulate gene expression in eukaryotes?
By looping DNA to interact with promoters
Test your knowledge on the levels of gene regulation, transcriptional regulatory mechanisms in yeast, basics of epigenetics such as DNA methylation, and post-transcriptional mechanisms like RNA interference and microRNAs. This quiz covers fundamental concepts of modern molecular biology.
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