20 Questions
What is the characteristic of the DNA of HSV1 and HSV2?
Double-stranded and linear
Where does HSV1 primarily replicate?
In the nucleus
What is the characteristic appearance of Cowdry bodies in HSV1 and HSV2 infections?
Target-like structures
What is the primary mode of transmission of HSV1 and HSV2?
Through sexual contact and saliva
What is the common complication of HSV1 infection in the eye?
Keratoconjunctivitis
What is the characteristic of herpes labialis caused by HSV1?
Ulcers on the lips
What is the site of latency for HSV1?
Trigeminal ganglia
What is the characteristic of Tzanck smear in HSV1 and HSV2 infections?
Presence of multinucleated giant cells
What is the complication of HSV2 infection in the central nervous system?
Encephalitis
What is the characteristic of herpes whitlow caused by HSV1?
Painful vesicular lesions on the fingers
What is the primary site of infection for HSV1?
Upper half of the body
What is the characteristic appearance of HSV1 ulcers on the lips?
Snake-like ulcers
What is the common complication of HSV1 infection in the brain?
Encephalitis
What is the characteristic of HSV2 infection in the genital region?
Painful vesicular lesions
Where does HSV2 primarily replicate?
Sacral ganglia
What is the characteristic of HSV1 latency?
Latent in trigeminal ganglia
What is the characteristic of HSV2 transmission?
Through sex and vertically
What is the characteristic of Erythema multiforme in HSV1 infection?
Target lesions on the hands and feet
What is the characteristic of Tzanck smear in HSV1 and HSV2 infections?
Multinucleated giant cells
What is the characteristic of herpes labialis caused by HSV1?
Ulcers on the lips
Study Notes
HSV1 and HSV2
- Both are DNA viruses and belong to the Herpesviridae family
- Enveloped viruses with double-stranded linear DNA genomes
- Replicate in the nucleus
Characteristics of HSV Infections
- Transmitted via sexual contact, saliva, and vertically from mother to child
- Two strains: HSV1 and HSV2, with different symptoms and locations
- Can cause latent infections, reacting in trigeminal ganglia (HSV1) and sacral ganglia (HSV2)
HSV1 Infections
- Typically affects the upper half of the body
- Causes inflamed lips, ulcers on lips, and Keratoconjunctivitis
- Can lead to Temporal lobe encephalitis with bizarre behavior
- Most common cause of sporadic encephalitis
- Latent in trigeminal ganglia
- Can cause herpetic whitlow (dew drop on a rose petal appearance)
HSV2 Infections
- Typically affects the genital region
- Causes painful vesicular lesions, inguinal lymphadenopathy, and meningitis
- Latent in sacral ganglia
- Can cause neonatal herpes
Diagnosis and Treatment
- Diagnosed using Tzanc smear to identify multinucleated giant cells
- No cure, but can be managed with acyclovir and valcyclovir to prevent breakouts
- Similar inclusion bodies can be found in cytoplasm in Pox virus infections
HSV1 and HSV2
- Both are DNA viruses and belong to the Herpesviridae family
- Enveloped viruses with double-stranded linear DNA genomes
- Replicate in the nucleus
Characteristics of HSV Infections
- Transmitted via sexual contact, saliva, and vertically from mother to child
- Two strains: HSV1 and HSV2, with different symptoms and locations
- Can cause latent infections, reacting in trigeminal ganglia (HSV1) and sacral ganglia (HSV2)
HSV1 Infections
- Typically affects the upper half of the body
- Causes inflamed lips, ulcers on lips, and Keratoconjunctivitis
- Can lead to Temporal lobe encephalitis with bizarre behavior
- Most common cause of sporadic encephalitis
- Latent in trigeminal ganglia
- Can cause herpetic whitlow (dew drop on a rose petal appearance)
HSV2 Infections
- Typically affects the genital region
- Causes painful vesicular lesions, inguinal lymphadenopathy, and meningitis
- Latent in sacral ganglia
- Can cause neonatal herpes
Diagnosis and Treatment
- Diagnosed using Tzanc smear to identify multinucleated giant cells
- No cure, but can be managed with acyclovir and valcyclovir to prevent breakouts
- Similar inclusion bodies can be found in cytoplasm in Pox virus infections
This quiz covers the characteristics and features of Herpes Simplex Virus 1 and 2, including their structure, replication, and transmission.
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