Podcast
Questions and Answers
Which type of epithelium does HPV infect?
Which type of epithelium does HPV infect?
- Simple columnar epithelium
- Stratified squamous epithelium (correct)
- Transitional epithelium
- Pseudostratified ciliated columnar epithelium
How many HPV types have been identified to infect both skin and oral cavity?
How many HPV types have been identified to infect both skin and oral cavity?
- Around 50
- Exactly 100
- Over 130 (correct)
- Less than 20
Where is squamous papilloma most commonly located in the oral cavity?
Where is squamous papilloma most commonly located in the oral cavity?
- Soft palate, tongue, and lips (correct)
- Floor of the mouth and tonsillar area
- Hard palate and buccal mucosa
- Gingiva and alveolar mucosa
Which HPV types are associated with benign oral epithelial lesions?
Which HPV types are associated with benign oral epithelial lesions?
Which oral lesion is characterized by an exophytic nodule with numerous fingerlike surface projections above the mucosal lining?
Which oral lesion is characterized by an exophytic nodule with numerous fingerlike surface projections above the mucosal lining?
Which oral lesion presents as a painless papule or nodule with papillary projections and is caused by a common viral infection on the skin?
Which oral lesion presents as a painless papule or nodule with papillary projections and is caused by a common viral infection on the skin?
Which oral lesion is a sexually transmitted disease caused by HPV types 6 and 11, and commonly presents as an exophytic mass with short, blunted surface projections?
Which oral lesion is a sexually transmitted disease caused by HPV types 6 and 11, and commonly presents as an exophytic mass with short, blunted surface projections?
Which oral lesion is characterized by multiple well-demarcated pink, papules and nodules, predominantly involving children, and has a good prognosis with spontaneous regression or conservative surgical excision?
Which oral lesion is characterized by multiple well-demarcated pink, papules and nodules, predominantly involving children, and has a good prognosis with spontaneous regression or conservative surgical excision?
Which benign tumor clinically mimics HPV-related lesions, more common in adults, and is characterized by papillary surface projections?
Which benign tumor clinically mimics HPV-related lesions, more common in adults, and is characterized by papillary surface projections?
Flashcards
What is Verruca vulgaris?
What is Verruca vulgaris?
A common skin infection caused by a virus. It appears as a painless bump with tiny bumps (papillary projections) on its surface. Microscopically, it shows a difference in keratin granules compared to squamous papilloma.
What is a Squamous Papilloma?
What is a Squamous Papilloma?
A type of oral growth that is usually harmless and not contagious. It has a finger-like shape (papillary projections) and microscopically shows a white zone surrounding the nucleus.
Describe Condyloma Acuminatum.
Describe Condyloma Acuminatum.
A sexually transmitted infection caused by HPV types 6 and 11. It appears as a growth with short, blunt projections. Treatment involves removing the lesion.
What is Multifocal Epithelial Hyperplasia (Heck Disease)?
What is Multifocal Epithelial Hyperplasia (Heck Disease)?
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What is Verruciform Xanthoma?
What is Verruciform Xanthoma?
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What is Verrucous Carcinoma?
What is Verrucous Carcinoma?
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What are HPV-related Oropharyngeal Carcinomas?
What are HPV-related Oropharyngeal Carcinomas?
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What is the significance of HPV 16 in oral cancer?
What is the significance of HPV 16 in oral cancer?
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What is the significance of HPV status in oropharyngeal cancers?
What is the significance of HPV status in oropharyngeal cancers?
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Study Notes
- Mark Lerman wrote about various papillomas and their clinical presentations, histopathological features, and treatments in the article "Oral Papillomas: Clinical, Histopathological, and Therapeutic Aspects" published in 2016.
- Squamous Papilloma: an exophytic nodule with numerous fingerlike surface projections above the mucosal lining. Its histopathological presentation reveals squamous papillary epithelial proliferation and a white zone around the nucleus. It is not contagious and rarely malignant.
- Verruca vulgaris: a common viral infection on the skin with koilocytes (virus-altered epithelial cells). It presents as a painless papule or nodule with papillary projections, and its histopathological presentation shows the difference in keratohyalin granules between it and Squamous Papilloma.
- Condyloma Acuminatum: a sexually transmitted disease caused by HPV types 6 and 11. It presents as an exophytic mass with short, blunted surface projections, most commonly on the labial mucosa, lingual frenum, and the soft palate. It is treated by surgical excision for oral lesions.
- Multifocal Epithelial Hyperplasia (Heck Disease): a rare, non-specific condition characterized by multiple well-demarcated pink, papules and nodules, predominantly involving children. It arises from elongated rete ridges with mitosis-like cells and has a good prognosis with spontaneous regression or conservative surgical excision.
- Verruciform Xanthoma: a benign tumor clinically mimicking HPV-related lesions, it is more common in adults and is characterized by papillary surface projections, with no definitive role of HPV in its pathogenesis.
- HPV-induced malignant oral epithelial lesions: include Verrucous Carcinoma, a low-grade variant of oral squamous cell carcinoma associated with HPV types 6, 11, 16, and 18, and HPV-related oropharyngeal carcinomas, which are more common in the posterior tongue and have a better prognosis if HPV-positive.
- HPV 16 is a distinct subset of oral epithelial dysplasia. Persistent HPV 16 infection increases the risk of oropharyngeal carcinomas, which are identified in 90% of HPV+ oropharyngeal cancers. The most important prognostic factor is HPV status, with a better five-year survival rate for HPV-positive cases.
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