How Well Do You Understand Drug Accumulation and Clearance Assessment?

• The ratio of a plasma concentration after the second dose and the equivalent concentration at steady state
• The ratio of a plasma concentration at steady state and the equivalent concentration after the second dose
• The ratio of a plasma concentration after the first dose and the equivalent concentration at steady state
• The ratio of a plasma concentration at steady state and the equivalent concentration after the first dose (correct)

• It increases the half-life of the drug (correct)
• It decreases the half-life of the drug
• It increases the clearance of the drug
• It has no impact on the half-life of the drug

• When the drug is administered at a lower dose than normal
• When the drug has a wide therapeutic range
• When the drug has a narrow therapeutic range (correct)
• When the drug is administered at a higher dose than normal