How Well Do You Know Lymphocyte Migration Patterns?
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Questions and Answers

What is the main function of effector T cells?

  • To secrete antibodies
  • To migrate to lymph nodes and find antigens
  • To differentiate into plasma cells
  • To migrate to sites of infection and eliminate microbes (correct)

    • What is the function of plasma cells?

  • To migrate to sites of infection and eliminate microbes
  • To locate antigens
  • To differentiate into effector T cells
  • To secrete antibodies (correct)

    • What is the function of chemokines in the migration of naive T cells to lymph nodes?

  • To scan the surfaces of dendritic cells for antigens
  • To display antigens on HEV surfaces
  • To bind to the chemokine receptor CCR7 expressed on naive T cells (correct)
  • To migrate into the T cell zone

    • Which chemokine receptor is expressed on naive B cells?

    <p>CXCR5</p> Signup and view all the answers

    What happens when a T cell specifically recognizes an antigen on a dendritic cell?

    <p>The T cell forms stable conjugates with the dendritic cell and is activated</p> Signup and view all the answers

    Why are microbial antigens concentrated in the same regions of peripheral lymphoid organs through which naive T cells circulate?

    <p>To increase the likelihood of the correct T cell finding its antigen</p> Signup and view all the answers

    Where do most antibody-secreting plasma cells migrate to?

    <p>The bone marrow</p> Signup and view all the answers

    What are memory T cells?

    <p>T cells that can mount secondary responses to captured antigens</p> Signup and view all the answers

    Where do effector cells migrate to after they are generated upon T cell activation?

    <p>The infected tissues</p> Signup and view all the answers

    What is the function of naive lymphocytes?

    <p>To constantly recirculate between the blood and peripheral lymphoid organs</p> Signup and view all the answers

    What are high endothelial venules (HEVs)?

    <p>Specialized postcapillary venules through which naive T cells enter lymph nodes</p> Signup and view all the answers

    What controls the precise patterns of migration of naive and activated T cells?

    <p>Specific signals</p> Signup and view all the answers

    What is the main function of effector T cells?

    <p>To migrate to sites of infection and eliminate microbes</p> Signup and view all the answers

    What is the function of plasma cells?

    <p>To secrete antibodies</p> Signup and view all the answers

    What is the function of chemokines in the migration of naive T cells to lymph nodes?

    <p>To bind to the chemokine receptor CCR7 expressed on naive T cells</p> Signup and view all the answers

    Which chemokine receptor is expressed on naive B cells?

    <p>CXCR5</p> Signup and view all the answers

    What happens when a T cell specifically recognizes an antigen on a dendritic cell?

    <p>The T cell forms stable conjugates with the dendritic cell and is activated</p> Signup and view all the answers

    Why are microbial antigens concentrated in the same regions of peripheral lymphoid organs through which naive T cells circulate?

    <p>To increase the likelihood of the correct T cell finding its antigen</p> Signup and view all the answers

    Where do most antibody-secreting plasma cells migrate to?

    <p>The bone marrow</p> Signup and view all the answers

    What are memory T cells?

    <p>T cells that can mount secondary responses to captured antigens</p> Signup and view all the answers

    Where do effector cells migrate to after they are generated upon T cell activation?

    <p>The infected tissues</p> Signup and view all the answers

    What is the function of naive lymphocytes?

    <p>To constantly recirculate between the blood and peripheral lymphoid organs</p> Signup and view all the answers

    What are high endothelial venules (HEVs)?

    <p>Specialized postcapillary venules through which naive T cells enter lymph nodes</p> Signup and view all the answers

    What controls the precise patterns of migration of naive and activated T cells?

    <p>Specific signals</p> Signup and view all the answers

    Which type of lymphocyte does not need to migrate to sites of infection?

    <p>Plasma cells</p> Signup and view all the answers

    What is the role of effector T cells in combating infections?

    <p>They bind to and eliminate microbes at sites of infection</p> Signup and view all the answers

    What is the function of plasma cells in mucosal organs?

    <p>They secrete antibodies that enter the lumens of these organs</p> Signup and view all the answers

    How do naive T cells enter lymph nodes?

    <p>Through specialized postcapillary venules</p> Signup and view all the answers

    What is the function of chemokines produced in the T cell zones of the lymph nodes?

    <p>To bind to the chemokine receptor CCR7</p> Signup and view all the answers

    What is the role of dendritic cells in activating T cells?

    <p>To display antigens</p> Signup and view all the answers

    What is the function of effector cells?

    <p>To locate and eliminate microbes</p> Signup and view all the answers

    What is the role of chemokines that bind CXCR5?

    <p>To migrate B cells to follicles</p> Signup and view all the answers

    What is the function of memory T cells?

    <p>To mount secondary responses to captured antigens</p> Signup and view all the answers

    What is the likelihood of the correct T cell finding its antigen in peripheral lymphoid organs?

    <p>High</p> Signup and view all the answers

    Where do most plasma cells migrate to?

    <p>Bone marrow</p> Signup and view all the answers

    What is the role of memory cells that permanently reside in epithelial tissues?

    <p>To respond rapidly to eliminate the infection</p> Signup and view all the answers

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