How well do you know Ferroportin-l and Hephaestin?
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Questions and Answers

What is the main function of Ferroportin-l and Hephaestirf?

  • Transporting iron as Fe+2 from enterocytes and macrophage engulfed effete RBCs to circulation (correct)
  • Transporting iron as Fe+3 from enterocytes to circulation
  • Transporting iron as Fe+3 from circulation to enterocytes
  • Transporting iron as Fe+2 from circulation to enterocytes
  • Where is Ferroportin-q found and what is its function?

  • Found in the bone marrow and controls iron exit from cells into portal plasma
  • Found in the basolateral surface of duodenal enterocytes, placenta, macrophage and hepatocytes and controls iron exit from cells into portal plasma (correct)
  • Found in the basolateral surface of duodenal enterocytes, placenta, macrophage and hepatocytes and controls iron uptake
  • Found in the apotransferrin-Tf of bone marrow and controls iron uptake
  • What is the role of Hepcidin in iron homeostasis?

  • It acts as a receptor for Ferroportin-q
  • It controls the exit of iron from the cells into portal plasma
  • It controls the uptake of iron into the cells from portal plasma
  • It acts as a regulatory hormone of iron homeostasis by binding to Ferroportin-q and causing its internalization and degradation (correct)
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