How much do you know about TRH and its role in the endocrine system?
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Questions and Answers

Qual é a principal fonte de TRH que estimula a síntese e secreção de TSH?

  • A hipófise posterior
  • O pâncreas
  • O hipotálamo (correct)
  • O fígado
  • Qual é a principal fonte de síntese e secreção de TSH estimulada pela liberação de TRH?

  • A hipófise posterior
  • O córtex adrenal
  • O hipotálamo (correct)
  • O pâncreas
  • O que acontece quando há lesões que interrompem a liberação ou distribuição de TRH?

  • Aumento dos níveis basais de prolactina
  • Diminuição dos níveis basais de TSH (correct)
  • Aumento dos níveis basais de TSH
  • Diminuição dos níveis basais de prolactina
  • O que acontece quando há lesões que interrompem a liberação ou distribuição de TRH?

    <p>Diminuição nos níveis basais de TSH</p> Signup and view all the answers

    O que acontece quando TRH se liga ao receptor TRH em tireotrofos na hipófise anterior?

    <p>Ativa a via da fosfolipase C, levando à síntese e liberação de TSH</p> Signup and view all the answers

    O que acontece quando TRH se liga ao receptor de TRH em tireotrofos na hipófise anterior?

    <p>Ativa a via da fosfolipase C, levando à síntese e liberação de TSH</p> Signup and view all the answers

    Study Notes

    • TRH is a tripeptide hormone that contains the modified amino acid pyro-Glu.
    • It can be found in various tissues, but the hypothalamus is the main source that stimulates the synthesis and secretion of TSH.
    • TRH is transported to the anterior pituitary by the portal-hypophyseal system.
    • Lesions that interrupt TRH release or distribution cause a decrease in basal TSH levels.
    • TRH binds to the TRH receptor on thyrotrophs in the anterior pituitary.
    • Binding of TRH activates the phospholipase C pathway, leading to the synthesis and release of TSH.
    • TRH also activates the phospholipase A2 pathway, leading to the formation of biologically active eicosanoids.
    • TRH can increase plasma prolactin concentration by stimulating lactotrophs in the anterior pituitary.
    • There is no evidence indicating a regulatory role for TRH in prolactin secretion or action.
    • It is unclear if physiological surges of TRH release and TSH secretion occur.

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    Description

    Test your knowledge on TRH, the tripeptide hormone that plays a crucial role in the regulation of TSH secretion. Explore its mechanisms of action, distribution, and physiological effects, and gain a deeper understanding of the complex interplay between TRH and other hormones. This quiz will challenge your expertise on the topic with detailed questions and help you consolidate your understanding of this fascinating hormone.

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