6 Questions
Qual é a principal fonte de TRH que estimula a síntese e secreção de TSH?
O hipotálamo
Qual é a principal fonte de síntese e secreção de TSH estimulada pela liberação de TRH?
O hipotálamo
O que acontece quando há lesões que interrompem a liberação ou distribuição de TRH?
Diminuição dos níveis basais de TSH
O que acontece quando há lesões que interrompem a liberação ou distribuição de TRH?
Diminuição nos níveis basais de TSH
O que acontece quando TRH se liga ao receptor TRH em tireotrofos na hipófise anterior?
Ativa a via da fosfolipase C, levando à síntese e liberação de TSH
O que acontece quando TRH se liga ao receptor de TRH em tireotrofos na hipófise anterior?
Ativa a via da fosfolipase C, levando à síntese e liberação de TSH
Study Notes
- TRH is a tripeptide hormone that contains the modified amino acid pyro-Glu.
- It can be found in various tissues, but the hypothalamus is the main source that stimulates the synthesis and secretion of TSH.
- TRH is transported to the anterior pituitary by the portal-hypophyseal system.
- Lesions that interrupt TRH release or distribution cause a decrease in basal TSH levels.
- TRH binds to the TRH receptor on thyrotrophs in the anterior pituitary.
- Binding of TRH activates the phospholipase C pathway, leading to the synthesis and release of TSH.
- TRH also activates the phospholipase A2 pathway, leading to the formation of biologically active eicosanoids.
- TRH can increase plasma prolactin concentration by stimulating lactotrophs in the anterior pituitary.
- There is no evidence indicating a regulatory role for TRH in prolactin secretion or action.
- It is unclear if physiological surges of TRH release and TSH secretion occur.
Test your knowledge on TRH, the tripeptide hormone that plays a crucial role in the regulation of TSH secretion. Explore its mechanisms of action, distribution, and physiological effects, and gain a deeper understanding of the complex interplay between TRH and other hormones. This quiz will challenge your expertise on the topic with detailed questions and help you consolidate your understanding of this fascinating hormone.
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