4 Questions
Qu'est-ce que les systèmes de distribution transdermique ?
Des patchs appliqués sur la peau pour libérer des ingrédients actifs
Pour quels types de médicaments les systèmes de distribution transdermique sont-ils adaptés ?
Les médicaments qui traversent facilement la barrière cutanée, qui ont le bon équilibre hydrophile/lipophile, qui sont suffisamment petits pour diffuser à travers le stratum corneum et qui ne sont pas irritants ni sensibilisants.
Quels sont les avantages de la distribution transdermique par rapport à l'administration orale ou intraveineuse ?
Une libération continue de médicaments avec de courtes demi-vies biologiques, un risque plus faible de sur- ou sous-dosage et des horaires de dosage simplifiés.
Comment peut-on éliminer ou modifier la barrière cutanée pour augmenter la pénétration des médicaments ?
En utilisant des promoteurs d'absorption pour augmenter l'hydratation, la solubilité et la fluidité des lipides dans la peau
Study Notes
- Transdermal delivery systems are patches applied to the skin to release active ingredients.
- They are suitable for drugs that easily cross the skin barrier, have the right hydrophilic/lipophilic balance, are small enough to diffuse through the stratum corneum, and are non-irritating and non-sensitizing.
- Transdermal delivery has advantages over oral or IV administration, including continuous delivery of drugs with short biological half-lives, lower risk of over- or under-dosing, and simplified dosing schedules.
- The rate of drug release is regulated to ensure optimal absorption.
- Factors affecting absorption include temperature, hydration of the stratum corneum, surface area of application, and thickness of the stratum corneum.
- The skin barrier can be eliminated or modified to increase drug penetration.
- Promoters of absorption can increase hydration, solubility, and fluidity of lipids in the skin.
- Examples of promoters of absorption include short-chain alcohols, glycerol, and propylene glycol.
- Other methods for increasing absorption include the use of cyclodextrins, phospholipids, and surfactants.
- Transdermal delivery allows for precise dosing and easy discontinuation of treatment.
Are you familiar with transdermal delivery systems? Test your knowledge and learn more about these patches that release active ingredients through the skin. In this quiz, you will discover the advantages of transdermal delivery over other administration methods, factors affecting drug absorption, and ways to increase penetration. From factors affecting drug release rate to promoters of absorption, you'll explore the science behind transdermal delivery systems. Take the quiz now and see how much you know about this innovative drug delivery method!
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