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Questions and Answers
Which of the following is NOT a pathway through which complement can be activated?
Which of the following is NOT a pathway through which complement can be activated?
- Classical
- Alternative
- Lectin
- Innate (correct)
Which cells produce complement proteins?
Which cells produce complement proteins?
- T cells
- B cells
- Hepatocytes, tissue macrophages, and epithelial cells of the GI (correct)
- Red blood cells
What is required for complement proteins to be activated?
What is required for complement proteins to be activated?
- They are already activated when produced
- They require cleavage (correct)
- They require an antigen-antibody complex
- They require a specific type of cell to activate them
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Study Notes
- Complement is a group of serum proteins that enhance aspects of innate immunity and some effects of antibodies.
- It exists in an inactive form and is activated sequentially as a cascade.
- Complement proteins are proenzymes that require cleavage for activation.
- Complement components are designated by numbers or letters.
- Complement can be activated through three major pathways: classical, alternative, and lectin.
- The classical pathway is antibody-dependent and triggered by the formation of antigen-antibody complexes.
- The alternative pathway is antibody-independent and stimulated by antigens directly.
- The lectin pathway is also antibody-independent but resembles the classical pathway.
- Complement proteins are produced by hepatocytes, tissue macrophages, and epithelial cells of the GI.
- The heat-labile complement is a component of normal plasma.
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