Podcast
Questions and Answers
What is a telomere?
What is a telomere?
- A type of RNA primer
- A region at the end of chromosomes (correct)
- A type of DNA polymerase
- A protein that helps with replication
What are telomeres made of?
What are telomeres made of?
- Single-stranded RNA
- Repetitive sequences of non-coding DNA (correct)
- Repetitive sequences of coding DNA
- Proteins
When is replication at the chromosome end a problem in somatic cells?
When is replication at the chromosome end a problem in somatic cells?
- Only in the leading strand during replication
- Always in the lagging strand (correct)
- Only in the lagging strand during replication
- Always in the leading strand
What removes all the RNA primers during end replication problem in somatic cells?
What removes all the RNA primers during end replication problem in somatic cells?
What fills the gap created by the removal of RNA primers during end replication problem in somatic cells?
What fills the gap created by the removal of RNA primers during end replication problem in somatic cells?
Why can't the gap created at the 5’ end of the lagging strand be filled with DNA by polymerase during end replication problem in somatic cells?
Why can't the gap created at the 5’ end of the lagging strand be filled with DNA by polymerase during end replication problem in somatic cells?
What does the gap created at the 5’ end of the lagging strand during end replication problem in somatic cells result in?
What does the gap created at the 5’ end of the lagging strand during end replication problem in somatic cells result in?
Can the final gap created at the 5’ end of the lagging strand be filled in germ, stem & cancer cells?
Can the final gap created at the 5’ end of the lagging strand be filled in germ, stem & cancer cells?
What are RNase H and FEN1 responsible for during end replication problem in somatic cells?
What are RNase H and FEN1 responsible for during end replication problem in somatic cells?
Which strand experiences end replication problem during somatic cell division?
Which strand experiences end replication problem during somatic cell division?
What is a telomere?
What is a telomere?
What are telomeres made of?
What are telomeres made of?
When is replication at the chromosome end a problem in somatic cells?
When is replication at the chromosome end a problem in somatic cells?
What removes all the RNA primers during end replication problem in somatic cells?
What removes all the RNA primers during end replication problem in somatic cells?
What fills the gap created by the removal of RNA primers during end replication problem in somatic cells?
What fills the gap created by the removal of RNA primers during end replication problem in somatic cells?
Why can't the gap created at the 5’ end of the lagging strand be filled with DNA by polymerase during end replication problem in somatic cells?
Why can't the gap created at the 5’ end of the lagging strand be filled with DNA by polymerase during end replication problem in somatic cells?
What does the gap created at the 5’ end of the lagging strand during end replication problem in somatic cells result in?
What does the gap created at the 5’ end of the lagging strand during end replication problem in somatic cells result in?
Can the final gap created at the 5’ end of the lagging strand be filled in germ, stem & cancer cells?
Can the final gap created at the 5’ end of the lagging strand be filled in germ, stem & cancer cells?
What are RNase H and FEN1 responsible for during end replication problem in somatic cells?
What are RNase H and FEN1 responsible for during end replication problem in somatic cells?
Which strand experiences end replication problem during somatic cell division?
Which strand experiences end replication problem during somatic cell division?
What is a telomere?
What is a telomere?
What is the composition of telomeres?
What is the composition of telomeres?
Why is replication at the chromosome end (telomere) a problem in somatic cells?
Why is replication at the chromosome end (telomere) a problem in somatic cells?
What removes all the RNA primers during end replication problem in somatic cells?
What removes all the RNA primers during end replication problem in somatic cells?
What fills the gap created by the removal of RNA primers during end replication problem in somatic cells?
What fills the gap created by the removal of RNA primers during end replication problem in somatic cells?
Why can't the gap created at the 5’ end of the lagging strand be filled with DNA by polymerase during end replication problem in somatic cells?
Why can't the gap created at the 5’ end of the lagging strand be filled with DNA by polymerase during end replication problem in somatic cells?
Can the final gap created at the 5’ end of the lagging strand be filled in somatic cells?
Can the final gap created at the 5’ end of the lagging strand be filled in somatic cells?
Which cells can fill the final gap created at the 5’ end of the lagging strand?
Which cells can fill the final gap created at the 5’ end of the lagging strand?
What is the function of telomerase?
What is the function of telomerase?
What is the consequence of telomere shortening?
What is the consequence of telomere shortening?
What is the role of telomerase in germ, stem, and cancer cells?
What is the role of telomerase in germ, stem, and cancer cells?
What is the reason for the permanent gap (overhangs) in somatic cells?
What is the reason for the permanent gap (overhangs) in somatic cells?