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Cats with hypertrophic cardiomyopathy (HCM) are at risk of cardiogenic arterial thromboembolism (CATE). Neutrophil extracellular traps (NETs) may be a potential biomarker and therapeutic target for cardiomyopathy in cats. The study aimed to characterize NETs in cats with HCM or CATE. NETs were measured as cell-free DNA (cfDNA) and citrullinated histone H3 (citH3). Cats with CATE had significant increases in cfDNA compared to those without HCM. Citrullinated histone 3 was significantly lower in cats with HCM compared to those with CATE. CitH3 concentrations correlated significantly with reported risk factors of CATE. NETs, especially citH3, are increased in cats with HCM and CATE. They may serve as a novel therapeutic target and biomarker of thrombosis in cats with HCM. 85 cats were included in the study.
Cats with hypertrophic cardiomyopathy (HCM) are at risk of cardiogenic arterial thromboembolism (CATE). Neutrophil extracellular traps (NETs) may be a potential biomarker and therapeutic target for cardiomyopathy in cats. The study aimed to characterize NETs in cats with HCM or CATE. NETs were measured as cell-free DNA (cfDNA) and citrullinated histone H3 (citH3). Cats with CATE had significant increases in cfDNA compared to those without HCM. Citrullinated histone 3 was significantly lower in cats with HCM compared to those with CATE. CitH3 concentrations correlated significantly with reported risk factors of CATE. NETs, especially citH3, are increased in cats with HCM and CATE. They may serve as a novel therapeutic target and biomarker of thrombosis in cats with HCM. 85 cats were included in the study.
What is the potential biomarker and therapeutic target for cardiomyopathy in cats according to the study?
What is the potential biomarker and therapeutic target for cardiomyopathy in cats according to the study?
- Platelet count
- Neutrophil extracellular traps (NETs (correct)
- White blood cell count
- Red blood cell count
Cats with hypertrophic cardiomyopathy (HCM) are at risk of ______ arterial thromboembolism (CATE).
Cats with hypertrophic cardiomyopathy (HCM) are at risk of ______ arterial thromboembolism (CATE).
cardiogenic
What was the difference in citrullinated histone 3 (citH3) between cats with hypertrophic cardiomyopathy (HCM) and those with cardiogenic arterial thromboembolism (CATE)?
What was the difference in citrullinated histone 3 (citH3) between cats with hypertrophic cardiomyopathy (HCM) and those with cardiogenic arterial thromboembolism (CATE)?
Citrullinated histone 3 was significantly lower in cats with HCM compared to those with ______.
Citrullinated histone 3 was significantly lower in cats with HCM compared to those with ______.
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Study Notes
- Cats with hypertrophic cardiomyopathy (HCM) are at risk of cardiogenic arterial thromboembolism (CATE).
- Neutrophil extracellular traps (NETs) may be a potential biomarker and therapeutic target for cardiomyopathy in cats.
- The study aimed to characterize NETs in cats with HCM or CATE.
- NETs were measured as cell-free DNA (cfDNA) and citrullinated histone H3 (citH3).
- Cats with CATE had significant increases in cfDNA compared to those without HCM.
- Citrullinated histone 3 was significantly lower in cats with HCM compared to those with CATE.
- CitH3 concentrations correlated significantly with reported risk factors of CATE.
- NETs, especially citH3, are increased in cats with HCM and CATE.
- They may serve as a novel therapeutic target and biomarker of thrombosis in cats with HCM.
- 85 cats were included in the study.
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