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How much do you know about NETs and thrombosis in cats with HCM?

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How much do you know about NETs and thrombosis in cats with HCM?

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Questions and Answers

Cats with hypertrophic cardiomyopathy (HCM) are at risk of cardiogenic arterial thromboembolism (CATE). Neutrophil extracellular traps (NETs) may be a potential biomarker and therapeutic target for cardiomyopathy in cats. The study aimed to characterize NETs in cats with HCM or CATE. NETs were measured as cell-free DNA (cfDNA) and citrullinated histone H3 (citH3). Cats with CATE had significant increases in cfDNA compared to those without HCM. Citrullinated histone 3 was significantly lower in cats with HCM compared to those with CATE. CitH3 concentrations correlated significantly with reported risk factors of CATE. NETs, especially citH3, are increased in cats with HCM and CATE. They may serve as a novel therapeutic target and biomarker of thrombosis in cats with HCM. 85 cats were included in the study.

What is the potential biomarker and therapeutic target for cardiomyopathy in cats according to the study?

Platelet count

Neutrophil extracellular traps (NETs (correct)

White blood cell count

Red blood cell count

Cats with hypertrophic cardiomyopathy (HCM) are at risk of ______ arterial thromboembolism (CATE).

cardiogenic

What was the difference in citrullinated histone 3 (citH3) between cats with hypertrophic cardiomyopathy (HCM) and those with cardiogenic arterial thromboembolism (CATE)?

<p>CitH3 was significantly lower in cats with HCM compared to those with CATE</p> Signup and view all the answers

Citrullinated histone 3 was significantly lower in cats with HCM compared to those with ______.

<p>CATE.</p> Signup and view all the answers

Study Notes

Cats with hypertrophic cardiomyopathy (HCM) are at risk of cardiogenic arterial thromboembolism (CATE).
Neutrophil extracellular traps (NETs) may be a potential biomarker and therapeutic target for cardiomyopathy in cats.
The study aimed to characterize NETs in cats with HCM or CATE.
NETs were measured as cell-free DNA (cfDNA) and citrullinated histone H3 (citH3).
Cats with CATE had significant increases in cfDNA compared to those without HCM.
Citrullinated histone 3 was significantly lower in cats with HCM compared to those with CATE.
CitH3 concentrations correlated significantly with reported risk factors of CATE.
NETs, especially citH3, are increased in cats with HCM and CATE.
They may serve as a novel therapeutic target and biomarker of thrombosis in cats with HCM.
85 cats were included in the study.

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Description

Test your knowledge on the latest research about cardiomyopathy and thrombosis in cats! Discover the potential of neutrophil extracellular traps (NETs) as a biomarker and therapeutic target for this condition. Learn about the findings of a recent study that measured cell-free DNA and citrullinated histone H3 in cats with hypertrophic cardiomyopathy (HCM) and cardiogenic arterial thromboembolism (CATE). Challenge yourself with questions about the correlations between NETs