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Questions and Answers
What is the association between NKTCL and Epstein-Barr virus (EBV)?
What is the association between NKTCL and Epstein-Barr virus (EBV)?
- NKTCL is not associated with any viruses.
- NKTCL is associated with human papillomavirus (HPV).
- NKTCL is associated with hepatitis B virus (HBV).
- NKTCL is associated with Epstein-Barr virus (EBV). (correct)
What is the recommended treatment for NKTCL?
What is the recommended treatment for NKTCL?
- Early anthracycline-based chemotherapy
- Non-anthracycline-based chemotherapy (correct)
- Surgery
- Radiation therapy
What is the age range for NKTCL diagnosis?
What is the age range for NKTCL diagnosis?
- Approximately 20-30 years old
- Approximately 40-50 years old
- Approximately 60-70 years old (correct)
- Approximately 80-90 years old
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Study Notes
- Natural killer/T-cell lymphoma (NKTCL) is a rare and aggressive disease with poor prognosis.
- NKTCL is more prevalent in Asia and Latin America.
- The disease is associated with Epstein-Barr virus (EBV) and aberrant expression of CD21.
- Most tumor cells exhibit a cytotoxic phenotype, characterized by granzyme B and perforin expression.
- Early anthracycline-based chemotherapy resulted in poor outcomes due to intrinsic resistance of NKTCL cells to anthracycline.
- Combined modality therapy and non-anthracycline-based chemotherapy improved clinical outcomes.
- NK cells lack asparagine synthase activity, making neoplasms sensitive to l-asparaginase.
- Allogeneic hematopoietic stem cell transplantation (HSCT) has potential in patients with stage III/IV of the disease and in relapsed cases.
- NKTCL predominantly occurs in extranodal sites, including nasal or paranasal areas.
- The median age at diagnosis is approximately 65 years and there is a male predominance in NKTCL.
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