How much do you know about natriuretic peptides and their role in human health?

• Adipokines such as leptin, resistin, and visfatin stimulate ANP and BNP secretion in the heart of ob/ob mice.
• NPs activate lipolysis, enhance lipid oxidation, postprandial energy expenditure, and mitochondrial respiration.
• NPs activate PGC-1α and the proliferator-activated receptor-d, promoting muscle mitochondrial biogenesis and fat oxidation.
• CNP regulates energy metabolism through the control of adipogenesis, thermogenesis, and glucose clearance.
• Lower NPs circulating levels found in obese compared with lean healthy subjects may be due to increased expression of the NPRC in fat tissue or increased production of adipokines.
• ANP potentiates the effect of glucagon-like peptide 1 (GLP-1) on glucose-induced insulin secretion.
• Female and male sex steroid hormones influence NPs secretion, although with opposing effects.
• Hormone replacement therapy has a stimulatory action on the secretion of NPs in postmenopausal women.
• NPs inhibit the secretion of corticosteroids both directly and indirectly by inhibiting the RAS.
• ANP is more potent than BNP in inhibiting the aldosterone response to angiotensin-II.

Test your knowledge on the fascinating role of natriuretic peptides (NPs) in regulating energy metabolism, heart function, and hormone secretion. From adipokines to sex hormones, this quiz covers various aspects of NP physiology and their impact on human health. Get ready to learn about the latest research findings and broaden your understanding of this essential class of signaling molecules.