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Questions and Answers
Which of the following statements about NPs is true?
Which of the following statements about NPs is true?
- NPs have no effect on energy metabolism.
- NPs activate PGC-1α, promoting muscle mitochondrial biogenesis. (correct)
- NPs have no effect on fat oxidation.
- NPs inhibit the secretion of adipokines in obese individuals.
How do lower levels of NPs in obese individuals compared to lean individuals occur?
How do lower levels of NPs in obese individuals compared to lean individuals occur?
- Decreased expression of NPRC in fat tissue
- Increased expression of NPRC in fat tissue (correct)
- Decreased production of adipokines.
- Increased production of NPs.
Which of the following statements about ANP is true?
Which of the following statements about ANP is true?
- ANP has no effect on the secretion of glucagon-like peptide 1.
- ANP is less potent than BNP in inhibiting the aldosterone response to angiotensin-II.
- ANP inhibits the secretion of corticosteroids indirectly by inhibiting the RAS. (correct)
- ANP has no effect on glucose-induced insulin secretion.
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Study Notes
- Adipokines such as leptin, resistin, and visfatin stimulate ANP and BNP secretion in the heart of ob/ob mice.
- NPs activate lipolysis, enhance lipid oxidation, postprandial energy expenditure, and mitochondrial respiration.
- NPs activate PGC-1α and the proliferator-activated receptor-d, promoting muscle mitochondrial biogenesis and fat oxidation.
- CNP regulates energy metabolism through the control of adipogenesis, thermogenesis, and glucose clearance.
- Lower NPs circulating levels found in obese compared with lean healthy subjects may be due to increased expression of the NPRC in fat tissue or increased production of adipokines.
- ANP potentiates the effect of glucagon-like peptide 1 (GLP-1) on glucose-induced insulin secretion.
- Female and male sex steroid hormones influence NPs secretion, although with opposing effects.
- Hormone replacement therapy has a stimulatory action on the secretion of NPs in postmenopausal women.
- NPs inhibit the secretion of corticosteroids both directly and indirectly by inhibiting the RAS.
- ANP is more potent than BNP in inhibiting the aldosterone response to angiotensin-II.
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