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Questions and Answers
Which of the following statements about lncRNAs is true?
Which of the following statements about lncRNAs is true?
- They can regulate transcriptional activation or repression, splicing, and enhancer scaffolding. (correct)
- They are expressed at high levels and are not cell/tissue-specific
- They cannot bind to double-stranded DNA and RNA through base pairing.
- They are easily degraded and have a short lifetime
Which of the following is a function of Xist lncRNA?
Which of the following is a function of Xist lncRNA?
- It activates both X chromosomes during sex determination in mammals.
- It has no role in sex determination in mammals.
- It represses both X chromosomes during sex determination in mammals.
- It activates one X chromosome and represses the other during sex determination in mammals. (correct)
Which of the following is a way in which lncRNAs can modify RNA lifetime in the cytoplasm?
Which of the following is a way in which lncRNAs can modify RNA lifetime in the cytoplasm?
- They cannot modify RNA lifetime in the cytoplasm.
- They can interact with miRNAs. (correct)
- They can regulate transcriptional activation or repression.
- They can act as tethers to recruit other proteins/enzymes to specific genomic locations.
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Study Notes
- Circular RNAs (circRNAs) are more difficult to degrade and have a longer lifetime.
- Long non-coding RNAs (lncRNAs) are expressed at low levels and are cell/tissue-specific.
- lncRNAs can bind to double-stranded DNA and RNA through base pairing.
- lncRNAs can act as tethers to recruit other proteins/enzymes to specific genomic locations.
- lncRNAs can regulate transcriptional activation or repression, splicing, and enhancer scaffolding.
- The X-inactive specific transcript (Xist) lncRNA activates one X chromosome and represses the other during sex determination in mammals.
- Xist is processed like mRNA and is a pseudo gene.
- lncRNAs can have different functions depending on their sequence specificity and location.
- lncRNAs can interact with miRNAs and modify RNA lifetime in the cytoplasm.
- lncRNAs are important in gene regulation and development.
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