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Questions and Answers
What is the role of IgA and IgM in controlling Giardia lamblia infection?
What is the role of IgA and IgM in controlling Giardia lamblia infection?
- They promote attachment of the trophozoites to the intestinal epithelium
- They directly kill the trophozoites
- They inhibit attachment of the trophozoites to the intestinal epithelium (correct)
- They have no role in parasite clearance
Which immune cells are important for parasite clearance?
Which immune cells are important for parasite clearance?
- B cells
- CD4+ T cells (correct)
- NK cells
- CD8+ T cells
What happens to antibody levels in an immunocompromised patient with giardiasis?
What happens to antibody levels in an immunocompromised patient with giardiasis?
- Levels of IgG and IgM antibodies are increased, but IgA levels are decreased
- Levels of IgG, IgM, and IgA antibodies are increased
- Levels of IgG, IgM, and IgA antibodies are unchanged
- Levels of IgG, IgM, and IgA antibodies are depressed (correct)
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Study Notes
- Giardia lamblia is an extracellular parasite of the small intestine.
- Trophozoites display surface antigenic variation mediated by variant-specific surface proteins (VSP).
- Both humoral and cellular mechanisms are important for parasite clearance.
- IgA and IgM secretions of the host control the infection.
- Depletion of CD4+ T cells results in a marked decrease in parasite clearance.
- IgA-dependent host defenses are central for eradicating Giardia trophozoites.
- IgA binds to the surface of the trophozoite, inhibiting attachment to the intestinal epithelium.
- Specific IgA has been detected bound to trophozoite surfaces in human jejunal biopsies and jejunal fluid.
- In an immunocompromised patient, prolongation and recrudescence of giardiasis is evident.
- Levels of IgG, IgM, and IgA antibodies are depressed in an immunocompromised patient.
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