Podcast
Play an AI-generated podcast conversation about this lesson
Questions and Answers
What is the role of IgA and IgM in controlling Giardia lamblia infection?
What is the role of IgA and IgM in controlling Giardia lamblia infection?
- They promote attachment of the trophozoites to the intestinal epithelium
- They directly kill the trophozoites
- They inhibit attachment of the trophozoites to the intestinal epithelium (correct)
- They have no role in parasite clearance
Which immune cells are important for parasite clearance?
Which immune cells are important for parasite clearance?
- B cells
- CD4+ T cells (correct)
- NK cells
- CD8+ T cells
What happens to antibody levels in an immunocompromised patient with giardiasis?
What happens to antibody levels in an immunocompromised patient with giardiasis?
- Levels of IgG and IgM antibodies are increased, but IgA levels are decreased
- Levels of IgG, IgM, and IgA antibodies are increased
- Levels of IgG, IgM, and IgA antibodies are unchanged
- Levels of IgG, IgM, and IgA antibodies are depressed (correct)
Flashcards are hidden until you start studying
Study Notes
- Giardia lamblia is an extracellular parasite of the small intestine.
- Trophozoites display surface antigenic variation mediated by variant-specific surface proteins (VSP).
- Both humoral and cellular mechanisms are important for parasite clearance.
- IgA and IgM secretions of the host control the infection.
- Depletion of CD4+ T cells results in a marked decrease in parasite clearance.
- IgA-dependent host defenses are central for eradicating Giardia trophozoites.
- IgA binds to the surface of the trophozoite, inhibiting attachment to the intestinal epithelium.
- Specific IgA has been detected bound to trophozoite surfaces in human jejunal biopsies and jejunal fluid.
- In an immunocompromised patient, prolongation and recrudescence of giardiasis is evident.
- Levels of IgG, IgM, and IgA antibodies are depressed in an immunocompromised patient.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
