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Questions and Answers
What is an aerosol?
What is an aerosol?
- A gas suspended in a liquid
- A liquid suspended in a gas (correct)
- A solid suspended in a liquid
- A solid suspended in a gas
Why is aerosolized medication preferred over other forms of medication?
Why is aerosolized medication preferred over other forms of medication?
- It offers higher systemic levels
- It offers higher local drug concentration in the lung (correct)
- It has a longer shelf life
- It is easier to administer
What factors affect particle size in an aerosol?
What factors affect particle size in an aerosol?
- Substance, method used, and environmental conditions (correct)
- Temperature, pressure, and humidity
- Particle shape, color, and density
- None of the above
What is deposition in relation to aerosol?
What is deposition in relation to aerosol?
What are the primary mechanisms for deposition of small particles (1-5 µm) in the lung?
What are the primary mechanisms for deposition of small particles (1-5 µm) in the lung?
What is aging in relation to aerosol?
What is aging in relation to aerosol?
Which factors affect deposition of aerosol in the lungs?
Which factors affect deposition of aerosol in the lungs?
What types of inhalers are capable of delivering medication to target airway regions?
What types of inhalers are capable of delivering medication to target airway regions?
What is the primary deposition mechanism for very small particles deep within the lung (<3 µm)?
What is the primary deposition mechanism for very small particles deep within the lung (<3 µm)?
What is the primary deposition mechanism for larger particles (>5 µm)?
What is the primary deposition mechanism for larger particles (>5 µm)?
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Study Notes
- An aerosol is a suspension of solid or liquid particles in gas.
- Aerosolized medication offers higher local drug concentration in the lung with lower systemic levels.
- Particle size depends on the substance, method used, and environmental conditions.
- Deposition is the amount of drug inhaled and only a fraction of the emitted aerosol will be inhaled.
- Factors affecting deposition include inertial impaction, sedimentation, and Brownian motion.
- Sedimentation is the primary mechanism for deposition of small particles (1-5 µm).
- Brownian motion is the primary deposition mechanism for very small particles deep within the lung (<3 µm).
- Aging is the process by which an aerosol suspension changes over time.
- Other factors affecting deposition include inspiratory flow rate, flow pattern, respiratory rate, tidal volume, I:E ratio, and breath-holding.
- Metered Dose Inhalers and DPIs are capable of delivering medication to target airway regions.
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