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Questions and Answers
Which hormone controls body growth?
Which hormone controls body growth?
- Growth differentiation factor 15 (GDF-15 (correct)
- Soluble suppression of tumourigenesis-2
- Myostatin
- Endothelin-1
Which substances prevent cardiac fibrosis?
Which substances prevent cardiac fibrosis?
- Myostatin and FGFs
- Endothelin-1 (ET-1) and activin-A
- Fibroblast growth factors (FGFs
- GDF-15 and follistatin (correct)
Which factors decrease cardiac fatty acid oxidation and inhibit excessive autophagy?
Which factors decrease cardiac fatty acid oxidation and inhibit excessive autophagy?
- GDF-15 and follistatin
- Fibroblast growth factors (FGFs (correct)
- Endothelin-1 (ET-1) and activin-A
- Myostatin and FGFs
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Study Notes
- Cardiomyocytes release substances acting as hormones
- Growth differentiation factor 15 (GDF-15) controls body growth
- Myostatin modulates muscle mass
- Both hormones are increased in coronary heart disease (CHD) and HF
- Other factors released from the heart contribute to regulate myocyte growth and vascular remodelling
- GDF-15 and follistatin reduce ischaemia/reperfusion injury and pressure overload-induced hypertrophy
- Fibroblast growth factors (FGFs) decrease cardiac fatty acid oxidation and inhibit excessive autophagy
- Endothelin-1 (ET-1) and activin-A promote cardiomyocyte survival
- Soluble suppression of tumourigenesis-2 and FGFs prevent cardiac fibrosis
- These substances mainly exert autocrine/paracrine functions.
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