Hormonal Regulation of PFK-1 in the Liver

Play an AI-generated podcast conversation about this lesson

Which enzyme catalyzes the cleavage of F-1,6-BP into DHAP and GAP?

Aldolase (correct)

Triose phosphate isomerase

Glyceraldehyde 3-phosphate dehydrogenase

Phosphofructokinase-1

What is the main allosteric activator of phosphofructokinase-1 (PFK-1)?

Phosphoglycerate kinase

Glucagon

Fructose 2,6-bisphosphate (F-2,6-P) (correct)

Insulin

Which enzyme catalyzes the isomerization of DHAP into GAP?

Triose phosphate isomerase (correct)

Phosphofructokinase-1

Glyceraldehyde 3-phosphate dehydrogenase

Aldolase

Which enzyme catalyzes the phosphorylation of GAP using Pi?

Glyceraldehyde 3-phosphate dehydrogenase Signup and view all the answers

Which enzyme catalyzes the synthesis of phosphoenolpyruvate (PEP)?

Enolase Signup and view all the answers

Which hormone negatively regulates pyruvate kinase through phosphorylation?

Glucagon Signup and view all the answers

Which of the following is true about glycolysis?

Glycolysis is the only pathway that can produce energy for cells without mitochondria Signup and view all the answers

Which of the following is NOT a utilization of glucose in the body?

Sorbitol synthesis in the seminal vesicles Signup and view all the answers

What is the regulatory enzyme in glycolysis that is activated by high levels of AMP and F2,6-bisP?

Phosphofructokinase-1 (PFK-1) Signup and view all the answers

What is the difference between hexokinase and glucokinase?

Hexokinase is found in most tissues, while glucokinase is found in the liver and pancreas Signup and view all the answers

What is the name of the inherited disorder affecting the nervous system that is caused by deficiency of GLUT-1?

Glut1 deficiency syndrome Signup and view all the answers

Which enzyme reduces pyruvate to lactate in the absence of oxygen?

Lactate dehydrogenase (LDH) Signup and view all the answers

What happens to the pH when lactate is produced?

The pH decreases Signup and view all the answers

Which enzymes are associated with deficiencies causing hemolytic anemia?

Glucokinase, glucose phosphate isomerase/phosphoglucose isomerase, aldolase, triosephosphate isomerase, enolase, and pyruvate kinase Signup and view all the answers

What does aldolase B deficiency lead to?

Hypoglycemia, uricemia, and lactic acidemia Signup and view all the answers

What is the consequence of aldolase B deficiency in fructose intolerance?

Decreased glucose de novo synthesis Signup and view all the answers

What is the clinical consequence of phosphofructokinase deficiency?

Hemolytic anemia and muscle cramping Signup and view all the answers

Under which conditions can glycolysis operate?

Under both aerobic and anaerobic conditions Signup and view all the answers

Which process regulates glycolysis in different tissues or organs?

Substrate level phosphorylation Signup and view all the answers

What is the fate of pyruvate in different tissues and conditions?

Conversion to acetyl-CoA Signup and view all the answers

What are the irreversible steps in the glycolytic pathway?

Conversion of phosphoenolpyruvate to pyruvate Signup and view all the answers

What hormones are involved in the regulation of glycolysis?

Insulin and glucagon Signup and view all the answers