22 Questions
Which enzyme catalyzes the cleavage of F-1,6-BP into DHAP and GAP?
Aldolase
What is the main allosteric activator of phosphofructokinase-1 (PFK-1)?
Fructose 2,6-bisphosphate (F-2,6-P)
Which enzyme catalyzes the isomerization of DHAP into GAP?
Triose phosphate isomerase
Which enzyme catalyzes the phosphorylation of GAP using Pi?
Glyceraldehyde 3-phosphate dehydrogenase
Which enzyme catalyzes the synthesis of phosphoenolpyruvate (PEP)?
Enolase
Which hormone negatively regulates pyruvate kinase through phosphorylation?
Glucagon
Which of the following is true about glycolysis?
Glycolysis is the only pathway that can produce energy for cells without mitochondria
Which of the following is NOT a utilization of glucose in the body?
Sorbitol synthesis in the seminal vesicles
What is the regulatory enzyme in glycolysis that is activated by high levels of AMP and F2,6-bisP?
Phosphofructokinase-1 (PFK-1)
What is the difference between hexokinase and glucokinase?
Hexokinase is found in most tissues, while glucokinase is found in the liver and pancreas
What is the name of the inherited disorder affecting the nervous system that is caused by deficiency of GLUT-1?
Glut1 deficiency syndrome
Which enzyme reduces pyruvate to lactate in the absence of oxygen?
Lactate dehydrogenase (LDH)
What happens to the pH when lactate is produced?
The pH decreases
Which enzymes are associated with deficiencies causing hemolytic anemia?
Glucokinase, glucose phosphate isomerase/phosphoglucose isomerase, aldolase, triosephosphate isomerase, enolase, and pyruvate kinase
What does aldolase B deficiency lead to?
Hypoglycemia, uricemia, and lactic acidemia
What is the consequence of aldolase B deficiency in fructose intolerance?
Decreased glucose de novo synthesis
What is the clinical consequence of phosphofructokinase deficiency?
Hemolytic anemia and muscle cramping
Under which conditions can glycolysis operate?
Under both aerobic and anaerobic conditions
Which process regulates glycolysis in different tissues or organs?
Substrate level phosphorylation
What is the fate of pyruvate in different tissues and conditions?
Conversion to acetyl-CoA
What are the irreversible steps in the glycolytic pathway?
Conversion of phosphoenolpyruvate to pyruvate
What hormones are involved in the regulation of glycolysis?
Insulin and glucagon
Test your knowledge on the hormonal regulation of phosphofructokinase-1 (PFK-1) in the liver. Explore how hormones indirectly control PFK-1 through the synthesis of fructose 2,6-bisphosphate (F-2,6-P), the main allosteric activator of PFK-1. Learn about the impact of the insulin/glucagon ratio on PFK-1 regulation.
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