Hormonal Mode Of Action

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What can induce neoplasia through receptor-mediated mechanisms and perturbation of hormonal balance?

Non-DNA-reactive chemicals (correct)

Enzymes

Peptide hormones

Antioxidants

Which hormone can induce tumors in estrogen-dependent tissues?

Adrenaline

Estrogen (correct)

Growth hormone

Insulin

What is the mechanism of action for diethylstilbestrol (DES) in inducing changes that may lead to an abnormal number of chromosomes in a cell?

Inducing apoptosis

Interfering with the cell cycle and microtubule function (correct)

Inhibiting cell proliferation

Promoting DNA repair

Which chemicals found in soy products are considered phytoestrogens?

Genistein, daidzein, glycitein, equol Signup and view all the answers

What type of chemicals can induce tissue-specific changes through interaction with a receptor?

Hormonally active chemicals Signup and view all the answers

What is one of the major characteristics of a neoplasm as it progresses into a malignant state?

Resisting cell death Signup and view all the answers

Which process enables replicative immortality in neoplastic cells?

Reprogramming energy metabolism Signup and view all the answers

What is a characteristic of genotoxic/DNA-reactive compounds in relation to cell proliferation?

Irreversible effects on DNA Signup and view all the answers

What is the role of the tumor microenvironment in neoplastic growth and development?

Supporting normal stromal and inflammatory cells Signup and view all the answers

What is a characteristic of tumor promotion by carcinogens?

Limited to specific organs Signup and view all the answers

What characterizes the selective clonal expansion of initiated cells in the formation of preneoplastic lesions?

Produces a reversible lesion Signup and view all the answers

Which mechanism of action is associated with chemicals that induce cytotoxicity and persistent regenerative growth, potentially leading to DNA mutations?

Receptor-mediated Signup and view all the answers

Which chemical is an example of a substance that functions through cytotoxicity as a mode of action in chemical carcinogenesis?

D-Limonene Signup and view all the answers

Which mechanism of action involves chemicals that can alter the methylation status, contributing to neoplasia progression?

Immunosuppression Signup and view all the answers

Which receptor is associated with chemicals that act through a receptor-mediated mode of action in chemical carcinogenesis?

PPARα Signup and view all the answers

Which compound acts as an oxidative stress inducer, potentially contributing to the development of cancer?

Trichloroethylene Signup and view all the answers

Which chemical poses a risk of immunosuppression, potentially affecting the tumor microenvironment?

Atrazine Signup and view all the answers

Hormonal Mode Of Action

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