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Refers to the steady state of the pH of the body
When the pH value of body fluids is <7.3, characterized by excess hydrogen ions
When the pH value is >7.4, characterized by a low hydrogen ion concentration
Substances that can alter hydrogen ion concentration
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If respiratory rate decreases the rate at which carbon dioxide is eliminated decreases. The excess carbon dioxide reacts with water to form carbonic acid, which then dissociates into water and hydrogen ions. This will be evidenced in part by an increased partial pressure of carbon dioxide PCO2, which is known as ?
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Abnormalities in the respiratory system that cause an increase in respiratory rate (hyperventilation) result in a decrease in the concentration of carbon dioxide in the blood and a subsequent decrease in PCO3 in the blood, which is called ?
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The amount of strong acid or base that is required to titrate 1 L of blood to a pH of 7.4 at 37C while the PCO2 is held constant at 40 mm Hg - is called
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Conditions associated with altered sodium or potassium concentration
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Samples for calcium testing should not be collected using ____, because it binds to calcium and makes it unavailable for assay
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Study Notes
Acid-Base Balance
- Refers to the steady state of the pH of the body
Acidosis
- Characterized by excess hydrogen ions when the pH value of body fluids is <7.3
Alkalosis
- Characterized by a low hydrogen ion concentration when the pH value is >7.4
Factors Affecting Hydrogen Ion Concentration
- Substances that can alter hydrogen ion concentration
- Respiratory rate: decreased rate leads to excess carbon dioxide, forming carbonic acid, and increasing hydrogen ions and PCO2
- Respiratory rate: increased rate (hyperventilation) leads to decreased carbon dioxide in the blood, decreasing PCO2
Respiratory Acidoses
- Result from decreased respiratory rate, causing increased PCO2
Respiratory Alkaloses
- Result from increased respiratory rate (hyperventilation), causing decreased PCO2
Buffering Capacity
- The amount of strong acid or base required to titrate 1 L of blood to a pH of 7.4 at 37°C while PCO2 is held constant at 40 mm Hg
Electrolyte Imbalances
- Conditions associated with altered sodium or potassium concentration
Calcium Testing
- Samples should not be collected using oxalate, as it binds to calcium and makes it unavailable for assay
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