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Questions and Answers
What are the three components of all homeostatic control mechanisms?
What are the three components of all homeostatic control mechanisms?
Which system responds to changes in the environment and sends information to the control center along an afferent pathway?
Which system responds to changes in the environment and sends information to the control center along an afferent pathway?
What is the main function of the effector in a homeostatic control system?
What is the main function of the effector in a homeostatic control system?
What results from a disturbance in homeostasis according to the text?
What results from a disturbance in homeostasis according to the text?
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In a homeostatic imbalance, what happens to the equilibrium state of an organism?
In a homeostatic imbalance, what happens to the equilibrium state of an organism?
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What is the role of the control center in a homeostatic control system?
What is the role of the control center in a homeostatic control system?
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What is the main function of negative feedback mechanisms?
What is the main function of negative feedback mechanisms?
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In what process does positive feedback occur in the human body?
In what process does positive feedback occur in the human body?
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How do hormones and nervous signals differ in terms of duration and immediacy of effects?
How do hormones and nervous signals differ in terms of duration and immediacy of effects?
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What is the role of hormones in target tissue?
What is the role of hormones in target tissue?
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How does a positive feedback system differ from a negative feedback system?
How does a positive feedback system differ from a negative feedback system?
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What characterizes the effects of hormones in the body?
What characterizes the effects of hormones in the body?
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What is the main factor determining the sensitivity of a tissue to a hormone?
What is the main factor determining the sensitivity of a tissue to a hormone?
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How do peptide and protein hormones generally interact with target cells?
How do peptide and protein hormones generally interact with target cells?
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What is the role of a second messenger system for some cell-surface receptors?
What is the role of a second messenger system for some cell-surface receptors?
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How do steroid hormones enter target cells?
How do steroid hormones enter target cells?
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What happens once a hormone-receptor complex binds to specific sites on the cell’s DNA?
What happens once a hormone-receptor complex binds to specific sites on the cell’s DNA?
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Which type of hormones are used in direct gene activation through binding to a specific protein within the nucleus?
Which type of hormones are used in direct gene activation through binding to a specific protein within the nucleus?
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What is the biological half-life of a hormone?
What is the biological half-life of a hormone?
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How are peptide hormones primarily degraded?
How are peptide hormones primarily degraded?
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What regulates parathyroid hormone and calcitonin secretion?
What regulates parathyroid hormone and calcitonin secretion?
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Why are many synthetic hormones designed to have a longer half-life?
Why are many synthetic hormones designed to have a longer half-life?
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What follows exponential decay kinetics regarding hormone removal or inactivation?
What follows exponential decay kinetics regarding hormone removal or inactivation?
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What is the primary role of somatotrophin stimulation?
What is the primary role of somatotrophin stimulation?
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What is the main reason that steroid hormones are bound to protein carriers in blood?
What is the main reason that steroid hormones are bound to protein carriers in blood?
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What percentage of the hormone is typically present in the free or unbound form physiologically?
What percentage of the hormone is typically present in the free or unbound form physiologically?
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Which enzyme adds functional groups such as hydroxyl groups to steroids during the first phase of their degradation process?
Which enzyme adds functional groups such as hydroxyl groups to steroids during the first phase of their degradation process?
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How are the more water-soluble metabolites of steroids excreted from the body?
How are the more water-soluble metabolites of steroids excreted from the body?
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What is the primary role of phase one in the degradation process of steroids?
What is the primary role of phase one in the degradation process of steroids?
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Which hormone has a shorter half-life than that of human chorionic gonadotropin?
Which hormone has a shorter half-life than that of human chorionic gonadotropin?
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Study Notes
Homeostatic Control Mechanisms
- Three components: receptor (sensor), control center, and effector.
- Receptors respond to environmental changes and send information to the control center via afferent pathways.
Effectors and Homeostasis
- Effectors are responsible for executing responses that restore balance in homeostatic control systems.
- Disturbance in homeostasis can lead to disease or dysfunction within the organism.
Homeostatic Imbalance
- Homeostatic imbalance disrupts the equilibrium state, making the organism vulnerable to health issues.
Control Center Function
- The control center processes information received from receptors and determines necessary responses.
Feedback Mechanisms
- Negative feedback mechanisms work to reverse changes back to a set point, maintaining stability.
- Positive feedback amplifies responses, often occurring in processes like childbirth.
Hormonal and Nervous Responses
- Hormones typically have longer-lasting effects compared to the immediate responses of nervous signals.
Hormonal Action
- Hormones bind to specific receptors on target tissues to elicit physiological responses.
- Sensitivity of a target tissue to a hormone is primarily determined by the number of available receptors.
Hormone Interaction
- Peptide and protein hormones interact with cell-surface receptors and typically utilize second messenger systems.
- Steroid hormones enter target cells directly due to their lipid solubility and interact with intracellular receptors.
Gene Activation
- A hormone-receptor complex can bind to DNA’s specific sites, influencing gene expression and function.
- Steroid hormones achieve direct gene activation through binding to nuclear proteins.
Hormone Half-Life and Degradation
- The biological half-life of a hormone is the time it takes for its concentration to reduce by half.
- Peptide hormones are mainly degraded through enzymatic processes.
- Synthetic hormones often have longer half-lives to maintain therapeutic effectiveness.
Hormone Removal and Kinetics
- Hormone removal typically follows exponential decay kinetics, influencing the duration of hormone action.
Somatotrophin and Hormonal Binding
- Somatotrophin stimulation plays a significant role in growth and metabolism.
- Steroid hormones are often bound to protein carriers in blood to enhance solubility and extend circulation.
Hormone Concentration
- About 1-10% of hormones exist in their free, unbound form within the physiological environment.
Degradation Enzymes
- Specific enzymes, such as hydroxylases, add functional groups to steroids during their degradation process.
Excretion of Steroid Metabolites
- More water-soluble steroid metabolites are excreted through urine or bile after processing by the liver.
Phase One Degradation Role
- Phase one in steroid degradation changes steroid solubility, preparing them for further metabolic processes.
Short Half-Life Hormones
- A hormone like insulin has a shorter half-life compared to human chorionic gonadotropin.
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Description
Test your knowledge about the concept of homeostasis in animals, which enables them to regulate and maintain their internal environment despite external changes. Learn about the components of homeostatic control mechanisms and the importance of maintaining stable internal conditions in living organisms.