Homeostasis and Feedback Mechanisms
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Questions and Answers

What is the set point for blood glucose concentration in humans?

  • 4mmol/dm³
  • 7mmol/dm³
  • 6mmol/dm³
  • 5mmol/dm³ (correct)
  • Positive feedback mechanisms are common in the human body.

    False (B)

    What is the role of alpha cells in the pancreas?

    To secrete glucagon when blood glucose levels fall.

    Diabetes is the condition in which a person has consistently elevated blood glucose levels, leading to the presence of glucose in the ______.

    <p>urine</p> Signup and view all the answers

    Match the diabetes type with its description:

    <p>Type 1 = Autoimmune disease affecting insulin production Type 2 = Insulin resistance often due to lifestyle factors</p> Signup and view all the answers

    What substance is released by beta cells when blood glucose concentrations rise?

    <p>Insulin (A)</p> Signup and view all the answers

    Negative feedback mechanisms work to achieve balance within the body.

    <p>True (A)</p> Signup and view all the answers

    What happens to tissues when a person has diabetes?

    <p>They may become damaged.</p> Signup and view all the answers

    Which of the following factors is NOT a main risk factor for Type 2 diabetes?

    <p>High protein diet (C)</p> Signup and view all the answers

    Type 1 diabetes can be treated permanently using stem cells.

    <p>True (A)</p> Signup and view all the answers

    What is the human set point for core body temperature?

    <p>37°C</p> Signup and view all the answers

    The hypothalamus initiates responses to regulate body temperature when it detects __________ from thermoreceptors.

    <p>changes</p> Signup and view all the answers

    Match the following treatments for diabetes with their description:

    <p>Dietary adjustments = Adjusts food intake to manage blood glucose levels Insulin injections = Used to lower blood glucose before meals Exercise = Improves insulin uptake and action Implanted devices = Releases insulin automatically when needed</p> Signup and view all the answers

    Which hormone does the hypothalamus secrete to increase metabolic rate?

    <p>Thyrotropin releasing hormone (TRH) (C)</p> Signup and view all the answers

    What type of thermoreceptors are located in the skin?

    <p>Peripheral thermoreceptors</p> Signup and view all the answers

    Eating small amounts of food frequently helps in managing blood glucose levels in Type 2 diabetes.

    <p>True (A)</p> Signup and view all the answers

    What is the primary role of the loop of Henle?

    <p>To maintain the osmotic concentration gradient in the medulla (A)</p> Signup and view all the answers

    The filtrate in the descending limb of the loop of Henle becomes hypotonic as water leaves.

    <p>False (B)</p> Signup and view all the answers

    What hormone does the hypothalamus signal the pituitary gland to secrete when osmotic concentration is too high?

    <p>ADH</p> Signup and view all the answers

    If osmotic concentration is too low, the hypothalamus causes the pituitary gland to stop secreting _____, which leads to less water reabsorption.

    <p>ADH</p> Signup and view all the answers

    Match the following sections of the nephron with their function:

    <p>Proximal convoluted tubule = Reabsorption of water, ions, and nutrients Loop of Henle = Establishing osmotic gradient Distal convoluted tubule = Regulation of final water reabsorption Collecting duct = Final urine concentration</p> Signup and view all the answers

    Which of the following is NOT a response of the body to cold temperatures?

    <p>Sweating (B)</p> Signup and view all the answers

    Osmoregulation is exclusively the function of the kidneys.

    <p>False (B)</p> Signup and view all the answers

    What is the primary function of the nephron?

    <p>To filter blood and produce urine.</p> Signup and view all the answers

    Urea is produced in the liver during a process called __________.

    <p>deamination</p> Signup and view all the answers

    Match the kidney structure with its function:

    <p>Renal artery = Carries blood to the kidney Cortex = Outer region of the kidney Renal vein = Carries filtered blood away from the kidney Ureter = Transport urine from the kidney to the bladder</p> Signup and view all the answers

    What initiates the process of urine formation in the nephron?

    <p>Ultrafiltration (A)</p> Signup and view all the answers

    The loop of Henle is located in the renal medulla and is involved in concentrating urine.

    <p>True (A)</p> Signup and view all the answers

    What is the primary role of vasodilation in thermoregulation?

    <p>To increase blood flow to the skin and enhance heat loss.</p> Signup and view all the answers

    What is the primary function of fenestrations in the capillary walls?

    <p>To allow filtration of small molecules only (C)</p> Signup and view all the answers

    Most of the filtered fluid is returned to the blood capillaries after filtration.

    <p>True (A)</p> Signup and view all the answers

    What is the total volume of glomerular filtrate produced per day?

    <p>180 litres</p> Signup and view all the answers

    The filtered fluid that passes through the glomerulus is known as ________.

    <p>glomerular filtrate</p> Signup and view all the answers

    Match the following structures with their functions:

    <p>Afferent arteriole = Wider diameter allows more blood flow Efferent arteriole = Narrower diameter helps maintain pressure Podocytes = Form a network of slits for filtration Proximal convoluted tubule = Main site for reabsorption</p> Signup and view all the answers

    Which of the following is NOT reabsorbed in the proximal convoluted tubule?

    <p>Most proteins (A)</p> Signup and view all the answers

    The volume of urine produced daily is equal to the volume of glomerular filtrate.

    <p>False (B)</p> Signup and view all the answers

    What is the concentration gradient in the loop of Henle at the centre of the kidney?

    <p>1200 mOsm</p> Signup and view all the answers

    Flashcards

    What is Homeostasis?

    The maintenance of a constant internal environment in a living organism. This involves regulating factors like blood glucose, pH, and body temperature.

    What is Feedback in Homeostasis?

    A regulatory mechanism that uses the outcome of a process to influence its future course.

    What is Positive Feedback?

    A type of feedback where the output of a system amplifies the original stimulus, increasing the gap between the original and new levels.

    What is Negative Feedback?

    A type of feedback that reduces the gap between the original and new levels, achieving balance.

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    What is the Role of the Pancreas in Blood Glucose Regulation?

    The pancreas, a gland that has both exocrine and endocrine functions.

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    What is Glucagon?

    Hormone secreted by alpha cells in the pancreas when blood glucose levels fall. It stimulates the liver to release stored glucose into the bloodstream.

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    What is Insulin?

    Hormone secreted by beta cells in the pancreas when blood glucose levels rise. It prompts cells to absorb glucose from the bloodstream and use it for energy.

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    What is Diabetes?

    A condition characterized by chronically elevated blood glucose levels, even during fasting. This can lead to glucose in urine, damage to tissues, and dehydration.

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    Type 2 Diabetes

    A condition where the body can't use insulin properly due to a lack of insulin receptors or glucose transporters on target cells, leading to high blood sugar levels.

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    Thermoregulation

    The maintenance of a stable internal body temperature, usually around 37°C.

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    Negative Feedback

    A regulatory mechanism where a change in a controlled variable triggers a response that counteracts the change, bringing the variable back to the set point.

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    Thermoreceptors

    Specialized nerve endings that detect temperature changes in the body.

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    Peripheral Thermoreceptors

    Thermoreceptors located in the skin, detecting external temperature changes.

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    Central Thermoreceptors

    Thermoreceptors located in the core of the body, mainly in the hypothalamus, detecting internal temperature changes.

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    Vasoconstriction (in response to cold)

    The constriction of blood vessels, reducing blood flow to the skin and extremities, thereby conserving heat.

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    Shivering

    Involuntary muscle contractions that generate heat, helping to maintain body temperature.

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    Vasodilation (in response to heat)

    The dilation of blood vessels, increasing blood flow to the skin and extremities, which helps dissipate heat.

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    Osmoregulation

    The process by which the body maintains a stable internal water concentration.

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    Nephrons

    The functional units of the kidney responsible for filtering blood and producing urine.

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    Ultrafiltration

    The process of filtering blood in the glomerulus of the nephron, separating waste products from the blood to create urine.

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    Deamination

    The breakdown of excess amino acids in the liver, producing ammonia, which is then converted into urea for excretion.

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    What is the role of the Loop of Henle?

    The loop of Henle is a section of the nephron that helps concentrate urine and conserve water by creating a concentration gradient in the medulla of the kidney. It does this by selectively reabsorbing water and solutes in different parts of the loop.

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    Describe the permeability of the descending limb of the Loop of Henle.

    The descending limb of the loop of Henle is permeable to water but not very permeable to solutes. This means water moves out of the filtrate into the medullary interstitium, making the filtrate more concentrated.

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    Describe the permeability of the ascending limb of the Loop of Henle.

    The ascending limb of the loop of Henle is impermeable to water but permeable to solutes, especially Na+ (sodium). This causes sodium to move out of the filtrate, making it less concentrated.

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    What is the role of the Distal Convoluted Tubule?

    Distal convoluted tubules (DCT) are a part of the nephron where the final adjustments to urine composition take place. The DCT is relatively impermeable to water under normal conditions, but its permeability can be regulated by hormones, specifically ADH.

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    How does ADH affect urine concentration?

    Antidiuretic hormone (ADH) is a hormone released from the posterior pituitary gland in response to high blood osmolarity. It increases the permeability of the collecting duct to water, allowing for more water reabsorption back into the bloodstream and producing concentrated urine.

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    Tissue Fluid Formation

    The process where blood plasma is filtered out of blood capillaries to form tissue fluid, with most of the fluid returning to the capillaries.

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    Blood Pressure Role in Filtration

    The pressure exerted by blood against the walls of capillaries, which is higher than the pressure in surrounding tissues, promoting filtration of fluid.

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    Afferent Arteriole

    The blood vessel carrying blood into the glomerulus in the kidney. It has a wider diameter than the efferent arteriole, helping to maintain high pressure within the glomerulus.

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    Efferent Arteriole

    The blood vessel carrying blood out of the glomerulus. It has a narrower diameter than the afferent arteriole, contributing to high pressure within the glomerulus.

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    Fenestrations in Capillaries

    Tiny pores present in the walls of capillaries, especially in the glomerulus, that allow small molecules, like water, to pass through.

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    Glomerular Filtrate Definition

    The fluid that is filtered out of blood in the glomerulus of the kidney, consisting mainly of water, small solutes, and some waste products.

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    Basement Membrane in Glomerulus

    A layer of non-cellular gel in the glomerulus composed of glycoproteins that prevents large proteins from being filtered out.

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    Podocytes in Bowman's Capsule

    Specialized cells lining the inner wall of Bowman's capsule, resembling feet with slits between their extensions, allowing filtrate to pass through to the capsule.

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    Study Notes

    Homeostasis

    • Homeostasis is the maintenance of a constant internal body environment
    • Examples of factors maintained include blood glucose concentration, blood osmotic concentration, blood pH, and body temperature
    • Multicellular organisms have an advantage in regulated internal environments between cells

    Feedback Mechanisms

    • Feedback mechanisms use information about the outcome of a process to make decisions
    • Positive feedback increases the difference between the original level and the new level
    • Negative feedback reduces the difference, restoring the original level

    Blood Glucose Regulation

    • The set point for blood glucose concentration is 5mmol/dm³
    • Homeostasis is mediated by insulin and glucagon
    • Pancreas is both exocrine and endocrine
    • Exocrine glands have ducts, while endocrine glands secrete hormones directly into the bloodstream
    • Alpha cells secrete glucagon when blood glucose falls below the set point
    • Beta cells secrete insulin when blood glucose rises above the set point

    Types of Diabetes

    • Type 1 diabetes is an autoimmune disease damaging beta cells in the islets of Langerhans, leading to insufficient insulin production
    • Type 2 diabetes is the inability to process or respond to insulin due to a deficiency in insulin receptors on target cells. Risk factors include sugary/fatty diets, obesity, lack of exercise, and genetic factors

    Thermoregulation

    • Thermoregulation maintains an internal body temperature near 37°C
    • Negative feedback maintains temperature: If body temperature decreases, body generates heat. If body temperature increases, body loses heat
    • Thermoreceptors, located in the skin and the hypothalamus (part of the brain), monitor temperature
    • Responses to cold include vasoconstriction, shivering, and hair erection
    • Responses to heat include vasodilation, sweating, and increased metabolic rate
    • Hypothalamus, the part of the brain that regulates body temperature
    • Metabolic rate is influenced by the hypothalamus and thyroid hormones: hypothalamus' secretion of thyrotropin-releasing hormone (TRH) triggers the pituitary to secrete thyroid-stimulating hormone (TSH), which stimulates the thyroid gland to release thyroxine, increasing metabolic rate.

    Kidney and Osmoregulation

    • Osmoregulation maintains the osmotic concentration of body fluids within normal limits
    • Kidneys control water and salt balance
    • Kidneys remove waste and toxic products, including nitrogen-containing compounds (urea)
    • Kidneys remove extra substances not used by the body, like drugs or pigments from food
    • Kidneys filter substances in blood to produce urine
    • Filtrate is produced by high blood pressure in capillaries & filtered fluid is called glomerular filtrate. Blood cells and proteins are retained

    Nephron Structure and Function

    • Nephrons are the functional units of the kidney
    • Ultrafiltration is the first step of urine production in the Bowman's capsule which filters blood to create filtrate
    • Selective reabsorption is the second step: most water and minerals are reabsorbed into blood capillaries; glucose and amino acids are also reabsorbed. Reabsorption happens in proximal convoluted tubules through active transport, sodium ions, chloride ions, glucose via cotransporters, & water via osmosis
    • Loop of Henle maintains a concentration gradient, essential for water reabsorption
    • In the Loop of Henle, water moves from the filtrate into the blood via the descending limb, while salts leave.

    ADH and Osmoregulation

    • Osmoregulation involves the hypothalamus monitoring blood osmotic concentration

    • If osmotic concentration is too high, the hypothalamus signals pituitary to secrete ADH; ADH increases the permeability of the distal convoluted tubule, increasing water reabsorption, and decreasing the volume of urine.

    • Opposite happens when osmotic concentrations are low (less ADH, less water reabsorption)

    • Urine flows from the collecting duct to the pelvis and then to the urinary bladder

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    D3.3 Homeostasis PDF

    Description

    This quiz explores the concepts of homeostasis, feedback mechanisms, and blood glucose regulation. Understand how multicellular organisms maintain constant internal environments and the roles of insulin and glucagon in glucose management. Test your knowledge on the importance of feedback in biological processes.

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